Reviewed, UniProtKB/Swiss-Prot P0A257 (PLSC_SALTY)

Names and origin

Protein names

Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase
      Short name=1-AGP acyltransferase
      Short name=1-AGPAT
    EC=2.3.1.51
Alternative name(s):
    Lysophosphatidic acid acyltransferase
      Short name=LPAAT

Gene names

Name:	plsC
Synonyms:	parF
Ordered Locus Names:	STM3173

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-acyl-carrier-protein as the fatty acyl donor.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Subcellular location	Cell inner membrane; Peripheral membrane protein.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	1-acyl-sn-glycerol-3-phosphate acyltransferase		PRO_0000208178
Regions
	Motif	73 – 78	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	P0A257-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 5361B851BC96D919	FASTA	245	27,339
	10 20 30 40 50 60 MLYIFRLIVT VIYSILVCVF GSIYCLFSPR NPKHVATFGH MFGRLAPLFG LKVECRKPAD 70 80 90 100 110 120 AENYGNAIYI ANHQNNYDMV TAANIVQPPT VTVGKKSLLW IPFFGQLYWL TGNLLIDRNN 130 140 150 160 170 180 RAKAHSTIAA VVNHFKKRRI SIWMFPEGTR SRGRGLLPFK TGAFHAAIAA GVPIIPVCVS 190 200 210 220 230 240 NTSNKVNLNR LNNGLVIVEM LPPVDVSEYG KDQVRELAAH CRALMEQKIA ELDKEVAERE ATGKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cluster of genes that affects nucleoid segregation in Salmonella typhimurium." Luttinger A.L., Springer A.L., Schmid M.B. New Biol. 3:687-697(1991) [PubMed: 1751451] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.
[3]	Cong J., Schmid M.B. Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 236-245. Strain: LT2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M68936 Genomic DNA. Translation: AAA27181.1. AE006468 Genomic DNA. Translation: AAL22047.1. U09309 Unassigned DNA. Translation: AAA56678.1. Sequence problems.
PIR	B45582.
RefSeq	NP_462088.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P0A257.
Genome annotation databases
GeneID	1254696.
GenomeReviews	Gene locus STM3173 in contig AE006468_GR.
KEGG	stm:STM3173.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0A257.
OMA	KSLVWIP.
Enzyme and pathway databases
BioCyc	STYP99287:STM3173-MON.
BRENDA	2.3.1.51. 2.
Family and domain databases
InterPro	IPR002123. Acyltransferase. IPR004552. AGP_acyltrans. [Graphical view]
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00530. AGP_acyltrn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLSC_SALTY

Accession

Primary (citable) accession number: P0A257
Secondary accession number(s): P26974

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)