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Protein

Aminoglycoside N(3)-acetyltransferase III

Gene

aacC3

Organism
Enterobacter cloacae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3)-acetyltransferase III (EC:2.3.1.81)
Alternative name(s):
ACC(3)-III
Aminocyclitol 3-N-acetyltransferase type III
Gentamicin-(3)-N-acetyl-transferase
Gene namesi
Name:aacC3
Synonyms:aac3-VA, aacC2
Encoded oniPlasmid pJV030 Publication
OrganismiEnterobacter cloacae
Taxonomic identifieri550 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000685451 – 286Aminoglycoside N(3)-acetyltransferase IIIAdd BLAST286

Structurei

3D structure databases

ProteinModelPortaliP0A256
SMRiP0A256
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK19275

Family and domain databases

InterProiView protein in InterPro
IPR003679 Amioglycoside_AcTrfase
IPR028345 Antibiotic_NAT-like
PANTHERiPTHR11104 PTHR11104, 1 hit
PfamiView protein in Pfam
PF02522 Antibiotic_NAT, 1 hit
SUPFAMiSSF110710 SSF110710, 1 hit

Sequencei

Sequence statusi: Complete.

P0A256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTRKAITEA IRKLGVQTGD LLMVHASLKA IGPVEGGAET VVAALRSAVG
60 70 80 90 100
PTGTVMGYAS WDRSPYEETL NGARLDDKAR RTWPPFDPAT AGTYRGFGLL
110 120 130 140 150
NQFLVQAPGA RRSAHPDASM VAVGPLAETL TEPHELGHAL GEGSPVERFV
160 170 180 190 200
RLGGKALLLG APLNSVTALH YAEAVADIPN KRWVTYEMPM LGRNGEVAWK
210 220 230 240 250
TASEYDSNGI LDCFAIEGKP DAVETIANAY VKLGRHREGV VGFAQCYLFD
260 270 280
AQDIVTFGVT YLEKHFGATP IVPAHEAAQR SCEPSG
Length:286
Mass (Da):30,609
Last modified:March 1, 2005 - v1
Checksum:iAE30E9D093CBBD1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51534 Genomic DNA Translation: CAA35913.1
PIRiS09651
RefSeqiWP_000557452.1, NZ_PPHP01000027.1

Genome annotation databases

GeneIDi31349496
KEGGiag:CAA35913

Entry informationi

Entry nameiAACC3_ENTCL
AccessioniPrimary (citable) accession number: P0A256
Secondary accession number(s): P13245
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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