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P0A256

- AACC3_ENTCL

UniProt

P0A256 - AACC3_ENTCL

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Protein

Aminoglycoside N(3')-acetyltransferase III

Gene
aacC3, aac3-VA, aacC2
Organism
Enterobacter cloacae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1107-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
Alternative name(s):
ACC(3)-III
Aminocyclitol 3-N-acetyltransferase type III
Gentamicin-(3)-N-acetyl-transferase
Gene namesi
Name:aacC3
Synonyms:aac3-VA, aacC2
Encoded oniPlasmid pJV030 Publication
OrganismiEnterobacter cloacae
Taxonomic identifieri550 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Aminoglycoside N(3')-acetyltransferase IIIPRO_0000068545Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0A256.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A256-1 [UniParc]FASTAAdd to Basket

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MHTRKAITEA IRKLGVQTGD LLMVHASLKA IGPVEGGAET VVAALRSAVG    50
PTGTVMGYAS WDRSPYEETL NGARLDDKAR RTWPPFDPAT AGTYRGFGLL 100
NQFLVQAPGA RRSAHPDASM VAVGPLAETL TEPHELGHAL GEGSPVERFV 150
RLGGKALLLG APLNSVTALH YAEAVADIPN KRWVTYEMPM LGRNGEVAWK 200
TASEYDSNGI LDCFAIEGKP DAVETIANAY VKLGRHREGV VGFAQCYLFD 250
AQDIVTFGVT YLEKHFGATP IVPAHEAAQR SCEPSG 286
Length:286
Mass (Da):30,609
Last modified:March 1, 2005 - v1
Checksum:iAE30E9D093CBBD1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51534 Genomic DNA. Translation: CAA35913.1.
PIRiS09651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51534 Genomic DNA. Translation: CAA35913.1 .
PIRi S09651.

3D structure databases

ProteinModelPortali P0A256.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-1107-MONOMER.

Family and domain databases

InterProi IPR003679. Amioglycoside_AcTrfase.
[Graphical view ]
Pfami PF02522. Antibiotic_NAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the aacC2 gene, a gentamicin resistance determinant involved in a hospital epidemic of multiply resistant members of the family Enterobacteriaceae."
    Vliegenthart J.S., Ketelaar-Van Gaalen P.A.G., van de Klundert J.A.M.
    Antimicrob. Agents Chemother. 33:1153-1159(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiAACC3_ENTCL
AccessioniPrimary (citable) accession number: P0A256
Secondary accession number(s): P13245
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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