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P0A255

- AAC32_SALSP

UniProt

P0A255 - AAC32_SALSP

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Protein
Aminoglycoside N(3')-acetyltransferase III
Gene
aacC3, aac3-VA, aacC2
Organism
Salmonella sp.
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Catalytic activityi

Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

GO - Molecular functioni

  1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
Alternative name(s):
ACC(3)-III
Aminocyclitol 3-N-acetyltransferase type III
Gentamicin-(3)-N-acetyl-transferase
Gene namesi
Name:aacC3
Synonyms:aac3-VA, aacC2
Encoded oniPlasmid pWP116a1 Publication
Plasmid pWP14a1 Publication
OrganismiSalmonella sp.
Taxonomic identifieri599 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Aminoglycoside N(3')-acetyltransferase III
PRO_0000068544Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0A255.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003679. Amioglycoside_AcTrfase.
[Graphical view]
PfamiPF02522. Antibiotic_NAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A255-1 [UniParc]FASTAAdd to Basket

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MHTRKAITEA IRKLGVQTGD LLMVHASLKA IGPVEGGAET VVAALRSAVG    50
PTGTVMGYAS WDRSPYEETL NGARLDDKAR RTWPPFDPAT AGTYRGFGLL 100
NQFLVQAPGA RRSAHPDASM VAVGPLAETL TEPHELGHAL GEGSPVERFV 150
RLGGKALLLG APLNSVTALH YAEAVADIPN KRWVTYEMPM LGRNGEVAWK 200
TASEYDSNGI LDCFAIEGKP DAVETIANAY VKLGRHREGV VGFAQCYLFD 250
AQDIVTFGVT YLEKHFGATP IVPAHEAAQR SCEPSG 286
Length:286
Mass (Da):30,609
Last modified:March 1, 2005 - v1
Checksum:iAE30E9D093CBBD1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13541 Genomic DNA. Translation: CAA31891.1.
X13542 Genomic DNA. Translation: CAA31893.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13541 Genomic DNA. Translation: CAA31891.1 .
X13542 Genomic DNA. Translation: CAA31893.1 .

3D structure databases

ProteinModelPortali P0A255.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003679. Amioglycoside_AcTrfase.
[Graphical view ]
Pfami PF02522. Antibiotic_NAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes for gentamicin-(3)-N-acetyl-transferases III and IV. II. Nucleotide sequences of three AAC(3)-III genes and evolutionary aspects."
    Allmansberger R., Braeu B., Piepersberg W.
    Mol. Gen. Genet. 198:514-520(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Plasmid: pWP116a pWP14a

Entry informationi

Entry nameiAAC32_SALSP
AccessioniPrimary (citable) accession number: P0A255
Secondary accession number(s): P13245
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: April 16, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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