P0A255 (AAC32_SALSP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminoglycoside N(3')-acetyltransferase III
EC=2.3.1.81

Alternative name(s):
ACC(3)-III
Aminocyclitol 3-N-acetyltransferase type III
Gentamicin-(3)-N-acetyl-transferase

Gene names

Name:	aacC3
Synonyms:	aac3-VA, aacC2

Encoded on

Plasmid pWP116a Ref.1
Plasmid pWP14a Ref.1

Organism

Salmonella sp.

Taxonomic identifier

599 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.
Catalytic activity	Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.
Sequence similarities	Belongs to the antibiotic N-acetyltransferase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Molecular function	Acyltransferase Transferase
Technical term	Plasmid
Gene Ontology (GO)
Biological_process	response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminoglycoside 3-N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Aminoglycoside N(3')-acetyltransferase III		PRO_0000068544

Sequences

	Sequence		Length	Mass (Da)
	P0A255 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: AE30E9D093CBBD1F	FASTA	286	30,609
	10 20 30 40 50 60 MHTRKAITEA IRKLGVQTGD LLMVHASLKA IGPVEGGAET VVAALRSAVG PTGTVMGYAS 70 80 90 100 110 120 WDRSPYEETL NGARLDDKAR RTWPPFDPAT AGTYRGFGLL NQFLVQAPGA RRSAHPDASM 130 140 150 160 170 180 VAVGPLAETL TEPHELGHAL GEGSPVERFV RLGGKALLLG APLNSVTALH YAEAVADIPN 190 200 210 220 230 240 KRWVTYEMPM LGRNGEVAWK TASEYDSNGI LDCFAIEGKP DAVETIANAY VKLGRHREGV 250 260 270 280 VGFAQCYLFD AQDIVTFGVT YLEKHFGATP IVPAHEAAQR SCEPSG

References

[1]	"Genes for gentamicin-(3)-N-acetyl-transferases III and IV. II. Nucleotide sequences of three AAC(3)-III genes and evolutionary aspects." Allmansberger R., Braeu B., Piepersberg W. Mol. Gen. Genet. 198:514-520(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13541 Genomic DNA. Translation: CAA31891.1. X13542 Genomic DNA. Translation: CAA31893.1.
3D structure databases
ProteinModelPortal	P0A255.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003679. Amioglycoside_AcTrfase. [Graphical view]
Pfam	PF02522. Antibiotic_NAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAC32_SALSP

Accession

Primary (citable) accession number: P0A255
Secondary accession number(s): P13245

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	April 3, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program