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P0A255

- AAC32_SALSP

UniProt

P0A255 - AAC32_SALSP

Protein

Aminoglycoside N(3')-acetyltransferase III

Gene

aacC3

Organism
Salmonella sp.
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

    Catalytic activityi

    Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

    GO - Molecular functioni

    1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
    Alternative name(s):
    ACC(3)-III
    Aminocyclitol 3-N-acetyltransferase type III
    Gentamicin-(3)-N-acetyl-transferase
    Gene namesi
    Name:aacC3
    Synonyms:aac3-VA, aacC2
    Encoded oniPlasmid pWP116a1 Publication
    Plasmid pWP14a1 Publication
    OrganismiSalmonella sp.
    Taxonomic identifieri599 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Aminoglycoside N(3')-acetyltransferase IIIPRO_0000068544Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0A255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR003679. Amioglycoside_AcTrfase.
    [Graphical view]
    PfamiPF02522. Antibiotic_NAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A255-1 [UniParc]FASTAAdd to Basket

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    MHTRKAITEA IRKLGVQTGD LLMVHASLKA IGPVEGGAET VVAALRSAVG    50
    PTGTVMGYAS WDRSPYEETL NGARLDDKAR RTWPPFDPAT AGTYRGFGLL 100
    NQFLVQAPGA RRSAHPDASM VAVGPLAETL TEPHELGHAL GEGSPVERFV 150
    RLGGKALLLG APLNSVTALH YAEAVADIPN KRWVTYEMPM LGRNGEVAWK 200
    TASEYDSNGI LDCFAIEGKP DAVETIANAY VKLGRHREGV VGFAQCYLFD 250
    AQDIVTFGVT YLEKHFGATP IVPAHEAAQR SCEPSG 286
    Length:286
    Mass (Da):30,609
    Last modified:March 1, 2005 - v1
    Checksum:iAE30E9D093CBBD1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13541 Genomic DNA. Translation: CAA31891.1.
    X13542 Genomic DNA. Translation: CAA31893.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13541 Genomic DNA. Translation: CAA31891.1 .
    X13542 Genomic DNA. Translation: CAA31893.1 .

    3D structure databases

    ProteinModelPortali P0A255.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003679. Amioglycoside_AcTrfase.
    [Graphical view ]
    Pfami PF02522. Antibiotic_NAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes for gentamicin-(3)-N-acetyl-transferases III and IV. II. Nucleotide sequences of three AAC(3)-III genes and evolutionary aspects."
      Allmansberger R., Braeu B., Piepersberg W.
      Mol. Gen. Genet. 198:514-520(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Plasmid: pWP116a pWP14a

    Entry informationi

    Entry nameiAAC32_SALSP
    AccessioniPrimary (citable) accession number: P0A255
    Secondary accession number(s): P13245
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3