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P0A247 (VIRB_SHIFL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Virulence regulon transcriptional activator VirB
Alternative name(s):
Cell invasion regulator InvE
Gene names
Name:virB
Synonyms:invE
Ordered Locus Names:CP0123
Encoded onPlasmid pWR100 Ref.2 Ref.3
Plasmid pMYSH6000 Ref.1
Plasmid pINV_F6_M1382 Ref.4
Plasmid pCP301 Ref.5
OrganismShigella flexneri [Complete proteome] [HAMAP]
Taxonomic identifier623 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription activator for the invasion antigens IpaB, IpaC and IpaD. VirB is itself regulated by VirF.

Sequence similarities

Belongs to the ParB family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
Virulence
   LigandDNA-binding
   Molecular functionActivator
   Technical term3D-structure
Complete proteome
Plasmid
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Virulence regulon transcriptional activator VirB
PRO_0000178702

Regions

DNA binding152 – 17120H-T-H motif By similarity

Secondary structure

....................... 309
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A247 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: AD5FEEBEBFF6C0C4

FASTA30935,408
        10         20         30         40         50         60 
MVDLCNDLLS IKEGQKKEFT LHSGNKVSFI KAKIPHKRIQ DLTFVNQKTN VRDQESLTEE 

        70         80         90        100        110        120 
SLADIIKTIK LQQFFPVIGR EIDGRIEILD GTRRRASAIY AGADLEVLYS KEYISTLDAR 

       130        140        150        160        170        180 
KLANDIQTAK EHSIRELGIG LNFLKVSGMS YKDIAKKENL SRAKVTRAFQ AASVPQEIIS 

       190        200        210        220        230        240 
LFPIASELNF NDYKILFNYY KGLEKANESL SSTLPILKEE IKDLDTNLPP DIYKKEILNI 

       250        260        270        280        290        300 
IKKSKNRKQN PSLKVDSLFI SKDKRTYIKR KENKTNRTLI FTLSKINKTV QREIDEAIRD 


IISRHLSSS 

« Hide

References

« Hide 'large scale' references
[1]"A dual transcriptional activation system for the 230 kb plasmid genes coding for virulence-associated antigens of Shigella flexneri."
Adler B., Sasakawa C., Tobe T., Makino S., Komatsu K., Yoshikawa M.
Mol. Microbiol. 3:627-635(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: YSH6200 / Serotype 2a.
[2]"The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri."
Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H., Kunst F., Sansonetti P.J., Parsot C.
Mol. Microbiol. 38:760-771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: M90T / Serotype 5a.
[3]"Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri."
Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V., Blattner F.R.
Infect. Immun. 69:3271-3285(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: M90T / Serotype 5a.
[4]"Comparison of two major forms of the Shigella virulence plasmid pINV: positive selection is a major force driving the divergence."
Lan R., Stevenson G., Reeves P.R.
Infect. Immun. 71:6298-6306(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: M1382 / Serotype 6.
[5]"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. expand/collapse author list , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 301 / Serotype 2a.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14340 Genomic DNA. Translation: CAA32525.1.
AL391753 Genomic DNA. Translation: CAC05798.1.
AF348706 Genomic DNA. Translation: AAK18441.1.
AY206439 Genomic DNA. Translation: AAP78986.1.
AF386526 Genomic DNA. Translation: AAL72295.1.
PIRS04379.
RefSeqNP_085285.1. NC_002698.1.
NP_858256.1. NC_004851.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3VWBX-ray2.42A129-250[»]
3W2AX-ray2.78A129-250[»]
3W3CX-ray2.43A129-250[»]
ProteinModelPortalP0A247.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198214.CP0123.

Proteomic databases

PRIDEP0A247.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL72295; AAL72295; CP0123.
GeneID1237991.
876516.
KEGGsfl:CP0123.
PATRIC18722575. VBIShiFle86970_5378.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1475.
HOGENOMHOG000071678.
KOK03497.
OMARAACIYN.
OrthoDBEOG6HQSKQ.
ProtClustDBCLSK862821.

Family and domain databases

InterProIPR004437. ParB/RepB/Spo0J.
IPR003115. ParB/Sulfiredoxin_dom.
IPR014884. ParB_fam_C.
[Graphical view]
PfamPF08775. ParB. 1 hit.
PF02195. ParBc. 1 hit.
[Graphical view]
SMARTSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMSSF110849. SSF110849. 1 hit.
TIGRFAMsTIGR00180. parB_part. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVIRB_SHIFL
AccessionPrimary (citable) accession number: P0A247
Secondary accession number(s): P11656
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references