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P0A247

- VIRB_SHIFL

UniProt

P0A247 - VIRB_SHIFL

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Protein

Virulence regulon transcriptional activator VirB

Gene

virB

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Transcription activator for the invasion antigens IpaB, IpaC and IpaD. VirB is itself regulated by VirF.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi152 – 17120H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Virulence

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Virulence regulon transcriptional activator VirB
Alternative name(s):
Cell invasion regulator InvE
Gene namesi
Name:virB
Synonyms:invE
Ordered Locus Names:CP0123
Encoded oniPlasmid pWR1002 Publications
Plasmid pMYSH60001 Publication
Plasmid pINV_F6_M13821 Publication
Plasmid pCP3011 Publication
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Plasmid pCP301

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Virulence regulon transcriptional activator VirBPRO_0000178702Add
BLAST

Proteomic databases

PRIDEiP0A247.

Interactioni

Protein-protein interaction databases

STRINGi198214.CP0123.

Structurei

Secondary structure

1
309
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi134 – 1407
Helixi142 – 1454
Turni146 – 1483
Helixi151 – 1588
Helixi162 – 17211
Helixi176 – 1805
Helixi185 – 1873
Helixi190 – 20516
Turni211 – 2133
Helixi214 – 2229
Beta strandi227 – 2293
Helixi234 – 24512

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VWBX-ray2.42A129-250[»]
3W2AX-ray2.78A129-250[»]
3W3CX-ray2.43A129-250[»]
ProteinModelPortaliP0A247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ParB family.Curated

Phylogenomic databases

eggNOGiCOG1475.
HOGENOMiHOG000071678.
KOiK03497.
OMAiNANADEK.
OrthoDBiEOG6HQSKQ.

Family and domain databases

InterProiIPR004437. ParB/RepB/Spo0J.
IPR003115. ParB/Sulfiredoxin_dom.
IPR014884. ParB_fam_C.
[Graphical view]
PfamiPF08775. ParB. 1 hit.
PF02195. ParBc. 1 hit.
[Graphical view]
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.
TIGRFAMsiTIGR00180. parB_part. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A247-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDLCNDLLS IKEGQKKEFT LHSGNKVSFI KAKIPHKRIQ DLTFVNQKTN
60 70 80 90 100
VRDQESLTEE SLADIIKTIK LQQFFPVIGR EIDGRIEILD GTRRRASAIY
110 120 130 140 150
AGADLEVLYS KEYISTLDAR KLANDIQTAK EHSIRELGIG LNFLKVSGMS
160 170 180 190 200
YKDIAKKENL SRAKVTRAFQ AASVPQEIIS LFPIASELNF NDYKILFNYY
210 220 230 240 250
KGLEKANESL SSTLPILKEE IKDLDTNLPP DIYKKEILNI IKKSKNRKQN
260 270 280 290 300
PSLKVDSLFI SKDKRTYIKR KENKTNRTLI FTLSKINKTV QREIDEAIRD

IISRHLSSS
Length:309
Mass (Da):35,408
Last modified:March 1, 2005 - v1
Checksum:iAD5FEEBEBFF6C0C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14340 Genomic DNA. Translation: CAA32525.1.
AL391753 Genomic DNA. Translation: CAC05798.1.
AF348706 Genomic DNA. Translation: AAK18441.1.
AY206439 Genomic DNA. Translation: AAP78986.1.
AF386526 Genomic DNA. Translation: AAL72295.1.
PIRiS04379.
RefSeqiNP_085285.1. NC_002698.1.
NP_858256.1. NC_004851.1.

Genome annotation databases

EnsemblBacteriaiAAL72295; AAL72295; CP0123.
GeneIDi1237991.
876516.
KEGGisfl:CP0123.
PATRICi18722575. VBIShiFle86970_5378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14340 Genomic DNA. Translation: CAA32525.1 .
AL391753 Genomic DNA. Translation: CAC05798.1 .
AF348706 Genomic DNA. Translation: AAK18441.1 .
AY206439 Genomic DNA. Translation: AAP78986.1 .
AF386526 Genomic DNA. Translation: AAL72295.1 .
PIRi S04379.
RefSeqi NP_085285.1. NC_002698.1.
NP_858256.1. NC_004851.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VWB X-ray 2.42 A 129-250 [» ]
3W2A X-ray 2.78 A 129-250 [» ]
3W3C X-ray 2.43 A 129-250 [» ]
ProteinModelPortali P0A247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198214.CP0123.

Proteomic databases

PRIDEi P0A247.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL72295 ; AAL72295 ; CP0123 .
GeneIDi 1237991.
876516.
KEGGi sfl:CP0123.
PATRICi 18722575. VBIShiFle86970_5378.

Phylogenomic databases

eggNOGi COG1475.
HOGENOMi HOG000071678.
KOi K03497.
OMAi NANADEK.
OrthoDBi EOG6HQSKQ.

Family and domain databases

InterProi IPR004437. ParB/RepB/Spo0J.
IPR003115. ParB/Sulfiredoxin_dom.
IPR014884. ParB_fam_C.
[Graphical view ]
Pfami PF08775. ParB. 1 hit.
PF02195. ParBc. 1 hit.
[Graphical view ]
SMARTi SM00470. ParB. 1 hit.
[Graphical view ]
SUPFAMi SSF110849. SSF110849. 1 hit.
TIGRFAMsi TIGR00180. parB_part. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A dual transcriptional activation system for the 230 kb plasmid genes coding for virulence-associated antigens of Shigella flexneri."
    Adler B., Sasakawa C., Tobe T., Makino S., Komatsu K., Yoshikawa M.
    Mol. Microbiol. 3:627-635(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: YSH6200 / Serotype 2a.
    Plasmid: pMYSH6000
  2. "The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri."
    Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H., Kunst F., Sansonetti P.J., Parsot C.
    Mol. Microbiol. 38:760-771(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M90T / Serotype 5a.
    Plasmid: pWR100
  3. "Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri."
    Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V., Blattner F.R.
    Infect. Immun. 69:3271-3285(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M90T / Serotype 5a.
    Plasmid: pWR100
  4. "Comparison of two major forms of the Shigella virulence plasmid pINV: positive selection is a major force driving the divergence."
    Lan R., Stevenson G., Reeves P.R.
    Infect. Immun. 71:6298-6306(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M1382 / Serotype 6.
    Plasmid: pINV_F6_M1382
  5. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
    Plasmid: pCP301

Entry informationi

Entry nameiVIRB_SHIFL
AccessioniPrimary (citable) accession number: P0A247
Secondary accession number(s): P11656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3