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Protein

Virulence regulon transcriptional activator VirB

Gene

virB

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription activator for the invasion antigens IpaB, IpaC and IpaD. VirB is itself regulated by VirF.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi152 – 171H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Virulence regulon transcriptional activator VirB
Alternative name(s):
Cell invasion regulator InvE
Gene namesi
Name:virB
Synonyms:invE
Ordered Locus Names:CP0123
Encoded oniPlasmid pWR1002 Publications
Plasmid pMYSH60001 Publication
Plasmid pINV_F6_M13821 Publication
Plasmid pCP3011 Publication
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000001006 Componenti: Plasmid pCP301

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001787021 – 309Virulence regulon transcriptional activator VirBAdd BLAST309

Proteomic databases

PRIDEiP0A247

Structurei

Secondary structure

1309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi134 – 140Combined sources7
Helixi142 – 145Combined sources4
Turni146 – 148Combined sources3
Helixi151 – 158Combined sources8
Helixi162 – 172Combined sources11
Helixi176 – 180Combined sources5
Helixi185 – 187Combined sources3
Helixi190 – 205Combined sources16
Turni211 – 213Combined sources3
Helixi214 – 222Combined sources9
Beta strandi227 – 229Combined sources3
Helixi234 – 245Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VWBX-ray2.42A129-250[»]
3W2AX-ray2.78A129-250[»]
3W3CX-ray2.43A129-250[»]
ProteinModelPortaliP0A247
SMRiP0A247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ParB family.Curated

Phylogenomic databases

eggNOGiENOG4106RMF Bacteria
COG1475 LUCA
HOGENOMiHOG000071678
KOiK03497
OMAiRIEIMDG

Family and domain databases

InterProiView protein in InterPro
IPR004437 ParB/RepB/Spo0J
IPR003115 ParB/Sulfiredoxin_dom
IPR036086 ParB/Sulfiredoxin_sf
IPR014884 ParB_fam_C
PfamiView protein in Pfam
PF08775 ParB, 1 hit
PF02195 ParBc, 1 hit
SMARTiView protein in SMART
SM00470 ParB, 1 hit
SUPFAMiSSF110849 SSF110849, 1 hit
TIGRFAMsiTIGR00180 parB_part, 1 hit

Sequencei

Sequence statusi: Complete.

P0A247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDLCNDLLS IKEGQKKEFT LHSGNKVSFI KAKIPHKRIQ DLTFVNQKTN
60 70 80 90 100
VRDQESLTEE SLADIIKTIK LQQFFPVIGR EIDGRIEILD GTRRRASAIY
110 120 130 140 150
AGADLEVLYS KEYISTLDAR KLANDIQTAK EHSIRELGIG LNFLKVSGMS
160 170 180 190 200
YKDIAKKENL SRAKVTRAFQ AASVPQEIIS LFPIASELNF NDYKILFNYY
210 220 230 240 250
KGLEKANESL SSTLPILKEE IKDLDTNLPP DIYKKEILNI IKKSKNRKQN
260 270 280 290 300
PSLKVDSLFI SKDKRTYIKR KENKTNRTLI FTLSKINKTV QREIDEAIRD

IISRHLSSS
Length:309
Mass (Da):35,408
Last modified:March 1, 2005 - v1
Checksum:iAD5FEEBEBFF6C0C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14340 Genomic DNA Translation: CAA32525.1
AL391753 Genomic DNA Translation: CAC05798.1
AF348706 Genomic DNA Translation: AAK18441.1
AY206439 Genomic DNA Translation: AAP78986.1
AF386526 Genomic DNA Translation: AAL72295.1
PIRiS04379
RefSeqiNP_085285.1, NC_002698.1
NP_858256.1, NC_004851.1
WP_000227976.1, NZ_MTPK01000040.1
YP_009062480.1, NC_024996.1

Genome annotation databases

EnsemblBacteriaiAAL72295; AAL72295; SF_p0123
GeneIDi1237991
876516
KEGGisfl:CP0123
PATRICifig|198214.7.peg.5378

Similar proteinsi

Entry informationi

Entry nameiVIRB_SHIFL
AccessioniPrimary (citable) accession number: P0A247
Secondary accession number(s): P11656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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