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Protein

Virulence regulon transcriptional activator VirB

Gene

virB

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator for the invasion antigens IpaB, IpaC and IpaD. VirB is itself regulated by VirF.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi152 – 17120H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Virulence

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Virulence regulon transcriptional activator VirB
Alternative name(s):
Cell invasion regulator InvE
Gene namesi
Name:virB
Synonyms:invE
Ordered Locus Names:CP0123
Encoded oniPlasmid pWR1002 Publications
Plasmid pMYSH60001 Publication
Plasmid pINV_F6_M13821 Publication
Plasmid pCP3011 Publication
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006 Componenti: Plasmid pCP301

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Virulence regulon transcriptional activator VirBPRO_0000178702Add
BLAST

Proteomic databases

PRIDEiP0A247.

Interactioni

Protein-protein interaction databases

STRINGi198214.CP0123.

Structurei

Secondary structure

1
309
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi134 – 1407Combined sources
Helixi142 – 1454Combined sources
Turni146 – 1483Combined sources
Helixi151 – 1588Combined sources
Helixi162 – 17211Combined sources
Helixi176 – 1805Combined sources
Helixi185 – 1873Combined sources
Helixi190 – 20516Combined sources
Turni211 – 2133Combined sources
Helixi214 – 2229Combined sources
Beta strandi227 – 2293Combined sources
Helixi234 – 24512Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VWBX-ray2.42A129-250[»]
3W2AX-ray2.78A129-250[»]
3W3CX-ray2.43A129-250[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ParB family.Curated

Phylogenomic databases

eggNOGiCOG1475.
HOGENOMiHOG000071678.
KOiK03497.
OMAiNANADEK.
OrthoDBiEOG6HQSKQ.

Family and domain databases

InterProiIPR004437. ParB/RepB/Spo0J.
IPR003115. ParB/Sulfiredoxin_dom.
IPR014884. ParB_fam_C.
[Graphical view]
PfamiPF08775. ParB. 1 hit.
PF02195. ParBc. 1 hit.
[Graphical view]
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.
TIGRFAMsiTIGR00180. parB_part. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDLCNDLLS IKEGQKKEFT LHSGNKVSFI KAKIPHKRIQ DLTFVNQKTN
60 70 80 90 100
VRDQESLTEE SLADIIKTIK LQQFFPVIGR EIDGRIEILD GTRRRASAIY
110 120 130 140 150
AGADLEVLYS KEYISTLDAR KLANDIQTAK EHSIRELGIG LNFLKVSGMS
160 170 180 190 200
YKDIAKKENL SRAKVTRAFQ AASVPQEIIS LFPIASELNF NDYKILFNYY
210 220 230 240 250
KGLEKANESL SSTLPILKEE IKDLDTNLPP DIYKKEILNI IKKSKNRKQN
260 270 280 290 300
PSLKVDSLFI SKDKRTYIKR KENKTNRTLI FTLSKINKTV QREIDEAIRD

IISRHLSSS
Length:309
Mass (Da):35,408
Last modified:March 1, 2005 - v1
Checksum:iAD5FEEBEBFF6C0C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14340 Genomic DNA. Translation: CAA32525.1.
AL391753 Genomic DNA. Translation: CAC05798.1.
AF348706 Genomic DNA. Translation: AAK18441.1.
AY206439 Genomic DNA. Translation: AAP78986.1.
AF386526 Genomic DNA. Translation: AAL72295.1.
PIRiS04379.
RefSeqiNP_085285.1. NC_002698.1.
NP_858256.1. NC_004851.1.
YP_009062480.1. NC_024996.1.
YP_009074062.1. NG_034451.1.
YP_009078278.1. NG_035869.1.

Genome annotation databases

EnsemblBacteriaiAAL72295; AAL72295; SF_p0123.
GeneIDi1237991.
20467567.
876516.
KEGGipg:876516.
sfl:CP0123.
PATRICi18722575. VBIShiFle86970_5378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14340 Genomic DNA. Translation: CAA32525.1.
AL391753 Genomic DNA. Translation: CAC05798.1.
AF348706 Genomic DNA. Translation: AAK18441.1.
AY206439 Genomic DNA. Translation: AAP78986.1.
AF386526 Genomic DNA. Translation: AAL72295.1.
PIRiS04379.
RefSeqiNP_085285.1. NC_002698.1.
NP_858256.1. NC_004851.1.
YP_009062480.1. NC_024996.1.
YP_009074062.1. NG_034451.1.
YP_009078278.1. NG_035869.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VWBX-ray2.42A129-250[»]
3W2AX-ray2.78A129-250[»]
3W3CX-ray2.43A129-250[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.CP0123.

Proteomic databases

PRIDEiP0A247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL72295; AAL72295; SF_p0123.
GeneIDi1237991.
20467567.
876516.
KEGGipg:876516.
sfl:CP0123.
PATRICi18722575. VBIShiFle86970_5378.

Phylogenomic databases

eggNOGiCOG1475.
HOGENOMiHOG000071678.
KOiK03497.
OMAiNANADEK.
OrthoDBiEOG6HQSKQ.

Family and domain databases

InterProiIPR004437. ParB/RepB/Spo0J.
IPR003115. ParB/Sulfiredoxin_dom.
IPR014884. ParB_fam_C.
[Graphical view]
PfamiPF08775. ParB. 1 hit.
PF02195. ParBc. 1 hit.
[Graphical view]
SMARTiSM00470. ParB. 1 hit.
[Graphical view]
SUPFAMiSSF110849. SSF110849. 1 hit.
TIGRFAMsiTIGR00180. parB_part. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A dual transcriptional activation system for the 230 kb plasmid genes coding for virulence-associated antigens of Shigella flexneri."
    Adler B., Sasakawa C., Tobe T., Makino S., Komatsu K., Yoshikawa M.
    Mol. Microbiol. 3:627-635(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: YSH6200 / Serotype 2a.
    Plasmid: pMYSH6000
  2. "The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri."
    Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H., Kunst F., Sansonetti P.J., Parsot C.
    Mol. Microbiol. 38:760-771(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M90T / Serotype 5a.
    Plasmid: pWR100
  3. "Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri."
    Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V., Blattner F.R.
    Infect. Immun. 69:3271-3285(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M90T / Serotype 5a.
    Plasmid: pWR100
  4. "Comparison of two major forms of the Shigella virulence plasmid pINV: positive selection is a major force driving the divergence."
    Lan R., Stevenson G., Reeves P.R.
    Infect. Immun. 71:6298-6306(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M1382 / Serotype 6.
    Plasmid: pINV_F6_M1382
  5. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
    Plasmid: pCP301

Entry informationi

Entry nameiVIRB_SHIFL
AccessioniPrimary (citable) accession number: P0A247
Secondary accession number(s): P11656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: April 1, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.