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P0A247

- VIRB_SHIFL

UniProt

P0A247 - VIRB_SHIFL

Protein

Virulence regulon transcriptional activator VirB

Gene

virB

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Transcription activator for the invasion antigens IpaB, IpaC and IpaD. VirB is itself regulated by VirF.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi152 – 17120H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation, Virulence

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Virulence regulon transcriptional activator VirB
    Alternative name(s):
    Cell invasion regulator InvE
    Gene namesi
    Name:virB
    Synonyms:invE
    Ordered Locus Names:CP0123
    Encoded oniPlasmid pWR1002 Publications
    Plasmid pMYSH60001 Publication
    Plasmid pINV_F6_M13821 Publication
    Plasmid pCP3011 Publication
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Plasmid pCP301

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Virulence regulon transcriptional activator VirBPRO_0000178702Add
    BLAST

    Proteomic databases

    PRIDEiP0A247.

    Interactioni

    Protein-protein interaction databases

    STRINGi198214.CP0123.

    Structurei

    Secondary structure

    1
    309
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi134 – 1407
    Helixi142 – 1454
    Turni146 – 1483
    Helixi151 – 1588
    Helixi162 – 17211
    Helixi176 – 1805
    Helixi185 – 1873
    Helixi190 – 20516
    Turni211 – 2133
    Helixi214 – 2229
    Beta strandi227 – 2293
    Helixi234 – 24512

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VWBX-ray2.42A129-250[»]
    3W2AX-ray2.78A129-250[»]
    3W3CX-ray2.43A129-250[»]
    ProteinModelPortaliP0A247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ParB family.Curated

    Phylogenomic databases

    eggNOGiCOG1475.
    HOGENOMiHOG000071678.
    KOiK03497.
    OMAiNANADEK.
    OrthoDBiEOG6HQSKQ.

    Family and domain databases

    InterProiIPR004437. ParB/RepB/Spo0J.
    IPR003115. ParB/Sulfiredoxin_dom.
    IPR014884. ParB_fam_C.
    [Graphical view]
    PfamiPF08775. ParB. 1 hit.
    PF02195. ParBc. 1 hit.
    [Graphical view]
    SMARTiSM00470. ParB. 1 hit.
    [Graphical view]
    SUPFAMiSSF110849. SSF110849. 1 hit.
    TIGRFAMsiTIGR00180. parB_part. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A247-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDLCNDLLS IKEGQKKEFT LHSGNKVSFI KAKIPHKRIQ DLTFVNQKTN    50
    VRDQESLTEE SLADIIKTIK LQQFFPVIGR EIDGRIEILD GTRRRASAIY 100
    AGADLEVLYS KEYISTLDAR KLANDIQTAK EHSIRELGIG LNFLKVSGMS 150
    YKDIAKKENL SRAKVTRAFQ AASVPQEIIS LFPIASELNF NDYKILFNYY 200
    KGLEKANESL SSTLPILKEE IKDLDTNLPP DIYKKEILNI IKKSKNRKQN 250
    PSLKVDSLFI SKDKRTYIKR KENKTNRTLI FTLSKINKTV QREIDEAIRD 300
    IISRHLSSS 309
    Length:309
    Mass (Da):35,408
    Last modified:March 1, 2005 - v1
    Checksum:iAD5FEEBEBFF6C0C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14340 Genomic DNA. Translation: CAA32525.1.
    AL391753 Genomic DNA. Translation: CAC05798.1.
    AF348706 Genomic DNA. Translation: AAK18441.1.
    AY206439 Genomic DNA. Translation: AAP78986.1.
    AF386526 Genomic DNA. Translation: AAL72295.1.
    PIRiS04379.
    RefSeqiNP_085285.1. NC_002698.1.
    NP_858256.1. NC_004851.1.

    Genome annotation databases

    EnsemblBacteriaiAAL72295; AAL72295; CP0123.
    GeneIDi1237991.
    876516.
    KEGGisfl:CP0123.
    PATRICi18722575. VBIShiFle86970_5378.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14340 Genomic DNA. Translation: CAA32525.1 .
    AL391753 Genomic DNA. Translation: CAC05798.1 .
    AF348706 Genomic DNA. Translation: AAK18441.1 .
    AY206439 Genomic DNA. Translation: AAP78986.1 .
    AF386526 Genomic DNA. Translation: AAL72295.1 .
    PIRi S04379.
    RefSeqi NP_085285.1. NC_002698.1.
    NP_858256.1. NC_004851.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VWB X-ray 2.42 A 129-250 [» ]
    3W2A X-ray 2.78 A 129-250 [» ]
    3W3C X-ray 2.43 A 129-250 [» ]
    ProteinModelPortali P0A247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.CP0123.

    Proteomic databases

    PRIDEi P0A247.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL72295 ; AAL72295 ; CP0123 .
    GeneIDi 1237991.
    876516.
    KEGGi sfl:CP0123.
    PATRICi 18722575. VBIShiFle86970_5378.

    Phylogenomic databases

    eggNOGi COG1475.
    HOGENOMi HOG000071678.
    KOi K03497.
    OMAi NANADEK.
    OrthoDBi EOG6HQSKQ.

    Family and domain databases

    InterProi IPR004437. ParB/RepB/Spo0J.
    IPR003115. ParB/Sulfiredoxin_dom.
    IPR014884. ParB_fam_C.
    [Graphical view ]
    Pfami PF08775. ParB. 1 hit.
    PF02195. ParBc. 1 hit.
    [Graphical view ]
    SMARTi SM00470. ParB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110849. SSF110849. 1 hit.
    TIGRFAMsi TIGR00180. parB_part. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A dual transcriptional activation system for the 230 kb plasmid genes coding for virulence-associated antigens of Shigella flexneri."
      Adler B., Sasakawa C., Tobe T., Makino S., Komatsu K., Yoshikawa M.
      Mol. Microbiol. 3:627-635(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: YSH6200 / Serotype 2a.
      Plasmid: pMYSH6000
    2. "The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri."
      Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H., Kunst F., Sansonetti P.J., Parsot C.
      Mol. Microbiol. 38:760-771(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: M90T / Serotype 5a.
      Plasmid: pWR100
    3. "Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri."
      Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V., Blattner F.R.
      Infect. Immun. 69:3271-3285(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: M90T / Serotype 5a.
      Plasmid: pWR100
    4. "Comparison of two major forms of the Shigella virulence plasmid pINV: positive selection is a major force driving the divergence."
      Lan R., Stevenson G., Reeves P.R.
      Infect. Immun. 71:6298-6306(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: M1382 / Serotype 6.
      Plasmid: pINV_F6_M1382
    5. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
      Plasmid: pCP301

    Entry informationi

    Entry nameiVIRB_SHIFL
    AccessioniPrimary (citable) accession number: P0A247
    Secondary accession number(s): P11656
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Plasmid

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3