ID   PA1_SALTI               Reviewed;         289 AA.
AC   P0A232; P37442; Q9L6N9;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Phospholipase A1;
DE            EC=3.1.1.32;
DE            EC=3.1.1.4;
DE   AltName: Full=Detergent-resistant phospholipase A;
DE            Short=DR-phospholipase A;
DE   AltName: Full=Phosphatidylcholine 1-acylhydrolase;
DE   AltName: Full=Outer membrane phospholipase A;
DE            Short=OM PLA;
DE   Flags: Precursor;
GN   Name=pldA; OrderedLocusNames=STY3602, t3340;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   MEDLINE=21534947; PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P.,
RA   Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J.,
RA   Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K.,
RA   Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C.,
RA   Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K.,
RA   Whitehead S., Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella
RT   enterica serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   MEDLINE=22531367; PubMed=12644504;
RX   DOI=10.1128/JB.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J.,
RA   Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2
RT   and CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Hydrolysis of phosphatidylcholine with phospholipase A2
CC       (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Phosphatidylcholine + H(2)O = 2-
CC       acylglycerophosphocholine + a carboxylate.
CC   -!- CATALYTIC ACTIVITY: Phosphatidylcholine + H(2)O = 1-
CC       acylglycerophosphocholine + a carboxylate.
CC   -!- COFACTOR: Calcium (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane (By similarity).
CC       Note=One of the very few enzymes located there (By similarity).
CC   -!- SIMILARITY: Belongs to the phospholipase A1 family.
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DR   EMBL; AL627278; CAD07935.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70868.1; -; Genomic_DNA.
DR   RefSeq; NP_457794.1; -.
DR   RefSeq; NP_807008.1; -.
DR   HSSP; P00631; 1QD6.
DR   SMR; P0A232; 28-289.
DR   GeneID; 1071539; -.
DR   GeneID; 1249857; -.
DR   GenomeReviews; AE014613_GR; t3340.
DR   GenomeReviews; AL513382_GR; STY3602.
DR   KEGG; stt:t3340; -.
DR   KEGG; sty:STY3602; -.
DR   HOGENOM; P0A232; -.
DR   OMA; P0A232; YTRLMAQ.
DR   BioCyc; SENT209261:T3340-MON; -.
DR   BioCyc; SENT220341:STY3602-MON; -.
DR   BRENDA; 3.1.1.32; 3716.
DR   BRENDA; 3.1.1.4; 3716.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008970; F:phospholipase A1 activity; IEA:EC.
DR   GO; GO:0004623; F:phospholipase A2 activity; IEA:EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR003187; PLA1.
DR   Gene3D; G3DSA:2.40.230.10; PLA1; 1.
DR   Pfam; PF02253; PLA1; 1.
DR   PRINTS; PR01486; PHPHLIPASEA1.
PE   3: Inferred from homology;
KW   Calcium; Cell membrane; Cell outer membrane; Complete proteome;
KW   Hydrolase; Lipid degradation; Membrane; Signal.
FT   SIGNAL        1     20       By similarity.
FT   CHAIN        21    289       Phospholipase A1.
FT                                /FTId=PRO_0000021988.
FT   ACT_SITE    164    164       By similarity.
SQ   SEQUENCE   289 AA;  32967 MW;  DA97F5E1651C49C6 CRC64;
     MRAILRGLLP ATLLPLAAYA QEATIKEVHD APAVRGSIIA NMLQEHDNPF TLYPYDTNYL
     IYTNTSDLNK EAISTYNWSE NARKDEVKFQ LSLAFPLWRG ILGPNSVLGA SYTQKSWWQL
     SNSKESSPFR ETNYEPQLFL GFATDYRFAG WTLRDVEMGY NHDSNGRSDP TSRSWNRLYT
     RLMAENGNWL VEVKPWYVIG STDDNPDITK YMGYYQLKIG YHLGEAVLSA KGQYNWNTGY
     GGAEVGLSYP VTKHVRLYTQ VYSGYGESLI DYNFNQTRVG VGVMLNDIF
//