ID   PA1_SALTY               Reviewed;         289 AA.
AC   P0A231; P37442; Q9L6N9;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Phospholipase A1;
DE            EC=3.1.1.32;
DE            EC=3.1.1.4;
DE   AltName: Full=Detergent-resistant phospholipase A;
DE            Short=DR-phospholipase A;
DE   AltName: Full=Phosphatidylcholine 1-acylhydrolase;
DE   AltName: Full=Outer membrane phospholipase A;
DE            Short=OM PLA;
DE   Flags: Precursor;
GN   Name=pldA; OrderedLocusNames=STM3957; ORFNames=STMD1.33;
OS   Salmonella typhimurium.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90371;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=94131966; PubMed=8300539;
RA   Brok R.G.P.M., Brinkman E., van Boxtel R., Bekkers A.C.A.P.,
RA   Verheij H.M., Tommassen J.;
RT   "Molecular characterization of enterobacterial pldA genes encoding
RT   outer membrane phospholipase A.";
RL   J. Bacteriol. 176:861-870(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   MEDLINE=21534948; PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA   Waterston R., Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT   LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Hydrolysis of phosphatidylcholine with phospholipase A2
CC       (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.
CC   -!- CATALYTIC ACTIVITY: Phosphatidylcholine + H(2)O = 2-
CC       acylglycerophosphocholine + a carboxylate.
CC   -!- CATALYTIC ACTIVITY: Phosphatidylcholine + H(2)O = 1-
CC       acylglycerophosphocholine + a carboxylate.
CC   -!- COFACTOR: Calcium.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane. Note=One of the very
CC       few enzymes located there.
CC   -!- SIMILARITY: Belongs to the phospholipase A1 family.
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DR   EMBL; X76900; CAA54222.1; -; Genomic_DNA.
DR   EMBL; AF233324; AAF33435.1; -; Genomic_DNA.
DR   EMBL; AE008884; AAL22801.1; -; Genomic_DNA.
DR   PIR; A36971; A36971.
DR   RefSeq; NP_462842.1; -.
DR   HSSP; P00631; 1QD6.
DR   SMR; P0A231; 28-289.
DR   GeneID; 1255483; -.
DR   GenomeReviews; AE006468_GR; STM3957.
DR   KEGG; stm:STM3957; -.
DR   HOGENOM; P0A231; -.
DR   OMA; P0A231; YTRLMAQ.
DR   BioCyc; STYP99287:STM3957-MON; -.
DR   BRENDA; 3.1.1.32; 2.
DR   BRENDA; 3.1.1.4; 2.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008970; F:phospholipase A1 activity; IEA:EC.
DR   GO; GO:0004623; F:phospholipase A2 activity; IEA:EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR003187; PLA1.
DR   Gene3D; G3DSA:2.40.230.10; PLA1; 1.
DR   Pfam; PF02253; PLA1; 1.
DR   PRINTS; PR01486; PHPHLIPASEA1.
PE   3: Inferred from homology;
KW   Calcium; Cell membrane; Cell outer membrane; Complete proteome;
KW   Hydrolase; Lipid degradation; Membrane; Signal.
FT   SIGNAL        1     20       By similarity.
FT   CHAIN        21    289       Phospholipase A1.
FT                                /FTId=PRO_0000021989.
FT   ACT_SITE    164    164       By similarity.
FT   CONFLICT    155    155       D -> H (in Ref. 1; CAA54222).
FT   CONFLICT    174    174       S -> T (in Ref. 1; CAA54222).
SQ   SEQUENCE   289 AA;  32967 MW;  DA97F5E1651C49C6 CRC64;
     MRAILRGLLP ATLLPLAAYA QEATIKEVHD APAVRGSIIA NMLQEHDNPF TLYPYDTNYL
     IYTNTSDLNK EAISTYNWSE NARKDEVKFQ LSLAFPLWRG ILGPNSVLGA SYTQKSWWQL
     SNSKESSPFR ETNYEPQLFL GFATDYRFAG WTLRDVEMGY NHDSNGRSDP TSRSWNRLYT
     RLMAENGNWL VEVKPWYVIG STDDNPDITK YMGYYQLKIG YHLGEAVLSA KGQYNWNTGY
     GGAEVGLSYP VTKHVRLYTQ VYSGYGESLI DYNFNQTRVG VGVMLNDIF
//