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Protein

Protein MxiH

Gene

mxiH

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for the secretion of IPA invasins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MxiH
Gene namesi
Name:mxiH
Ordered Locus Names:CP0137
Encoded oniPlasmid pWR1004 Publications
Plasmid pCP3011 Publication
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
Proteomesi
  • UP000001006 Componenti: Plasmid pCP301

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8383Protein MxiHPRO_0000096659Add
BLAST

Proteomic databases

PaxDbiP0A223.
PRIDEiP0A223.

Interactioni

Protein-protein interaction databases

DIPiDIP-59026N.
STRINGi198214.CP0137.

Structurei

Secondary structure

1
83
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 3918Combined sources
Helixi44 – 7835Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CA5X-ray2.10A/B1-78[»]
2V6Lelectron microscopy16.000/1/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z1-83[»]
3J0Relectron microscopy7.70A2-83[»]
ProteinModelPortaliP0A223.
SMRiP0A223. Positions 15-75.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A223.

Family & Domainsi

Sequence similaritiesi

Belongs to the MxiH/PrgI/YscF family.Curated

Phylogenomic databases

eggNOGiENOG4105Y7Q. Bacteria.
ENOG411262J. LUCA.
HOGENOMiHOG000076952.
KOiK03221.
OMAiKDWTLSS.
OrthoDBiEOG6HXJBB.

Family and domain databases

InterProiIPR021123. T3SS_needle-like.
IPR011841. T3SS_needle_YscF.
[Graphical view]
PfamiPF09392. T3SS_needle_F. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02105. III_needle. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTVPNDDW TLSSLSETFD DGTQTLQGEL TLALDKLAKN PSNPQLLAEY
60 70 80
QSKLSEYTLY RNAQSNTVKV IKDVDAAIIQ NFR
Length:83
Mass (Da):9,265
Last modified:March 1, 2005 - v1
Checksum:iBA4D517D145345DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98390 Genomic DNA. Translation: AAA26530.1.
AL391753 Genomic DNA. Translation: CAC05812.1.
AF348706 Genomic DNA. Translation: AAK18456.1.
AF386526 Genomic DNA. Translation: AAL72553.1.
Z48957 Genomic DNA. Translation: CAA88823.1.
PIRiA45271.
RefSeqiNP_085300.1. NC_002698.1.
NP_858270.1. NC_004851.1.
YP_009062494.1. NC_024996.1.

Genome annotation databases

EnsemblBacteriaiAAL72553; AAL72553; SF_p0137.
GeneIDi1238256.
876534.
KEGGipg:20467582.
pg:876534.
sfl:CP0137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98390 Genomic DNA. Translation: AAA26530.1.
AL391753 Genomic DNA. Translation: CAC05812.1.
AF348706 Genomic DNA. Translation: AAK18456.1.
AF386526 Genomic DNA. Translation: AAL72553.1.
Z48957 Genomic DNA. Translation: CAA88823.1.
PIRiA45271.
RefSeqiNP_085300.1. NC_002698.1.
NP_858270.1. NC_004851.1.
YP_009062494.1. NC_024996.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CA5X-ray2.10A/B1-78[»]
2V6Lelectron microscopy16.000/1/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z1-83[»]
3J0Relectron microscopy7.70A2-83[»]
ProteinModelPortaliP0A223.
SMRiP0A223. Positions 15-75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59026N.
STRINGi198214.CP0137.

Proteomic databases

PaxDbiP0A223.
PRIDEiP0A223.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL72553; AAL72553; SF_p0137.
GeneIDi1238256.
876534.
KEGGipg:20467582.
pg:876534.
sfl:CP0137.

Phylogenomic databases

eggNOGiENOG4105Y7Q. Bacteria.
ENOG411262J. LUCA.
HOGENOMiHOG000076952.
KOiK03221.
OMAiKDWTLSS.
OrthoDBiEOG6HXJBB.

Miscellaneous databases

EvolutionaryTraceiP0A223.

Family and domain databases

InterProiIPR021123. T3SS_needle-like.
IPR011841. T3SS_needle_YscF.
[Graphical view]
PfamiPF09392. T3SS_needle_F. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02105. III_needle. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins."
    Allaoui A., Sansonetti P.J., Parsot C.
    J. Bacteriol. 174:7661-7669(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M90T / Serotype 5a.
    Plasmid: pWR100
  2. "The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri."
    Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H., Kunst F., Sansonetti P.J., Parsot C.
    Mol. Microbiol. 38:760-771(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M90T / Serotype 5a.
    Plasmid: pWR100
  3. "Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri."
    Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V., Blattner F.R.
    Infect. Immun. 69:3271-3285(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M90T / Serotype 5a.
    Plasmid: pWR100
  4. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
    Plasmid: pCP301
  5. "MxiG, a membrane protein required for secretion of Shigella spp. Ipa invasins: involvement in entry into epithelial cells and in intercellular dissemination."
    Allaoui A., Sansonetti P.J., Menard R., Barzu S., Mounier J., Phalipon A., Parsot C.
    Mol. Microbiol. 17:461-470(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-13.
    Strain: M90T / Serotype 5a.
    Plasmid: pWR100

Entry informationi

Entry nameiMXIH_SHIFL
AccessioniPrimary (citable) accession number: P0A223
Secondary accession number(s): Q06079, Q6LAA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: February 17, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.