Protein mxiH - Shigella flexneri

Contribute

Read comments (?) or add your own

P0A223 (MXIH_SHIFL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein mxiH

Gene names

Name:	mxiH
Ordered Locus Names:	CP0137

Encoded on

Plasmid pWR100 Ref.1 Ref.2 Ref.3 Ref.5
Plasmid pCP301 Ref.4

Organism

Shigella flexneri [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	83 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Necessary for the secretion of IPA invasins.
Sequence similarities	Belongs to the mxiH/prgI/yscF family.

Ontologies

Keywords
Biological process	Protein transport Transport Virulence
Technical term	3D-structure Complete proteome Plasmid
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

83

Protein mxiH

PRO_0000096659

Secondary structure

1

.

.

.

.

.

83

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

P0A223 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: BA4D517D145345DC
Show »

83

9,265

        10         20         30         40         50         60 
MSVTVPNDDW TLSSLSETFD DGTQTLQGEL TLALDKLAKN PSNPQLLAEY QSKLSEYTLY 

        70         80 
RNAQSNTVKV IKDVDAAIIQ NFR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins." Allaoui A., Sansonetti P.J., Parsot C. J. Bacteriol. 174:7661-7669(1992) [PubMed: 1332940] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: M90T / Serotype 5a.
[2]	"The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri." Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H., Kunst F., Sansonetti P.J., Parsot C. Mol. Microbiol. 38:760-771(2000) [PubMed: 11115111] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: M90T / Serotype 5a.
[3]	"Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri." Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V., Blattner F.R. Infect. Immun. 69:3271-3285(2001) [PubMed: 11292750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: M90T / Serotype 5a.
[4]	"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. Yu J. Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a.
[5]	"MxiG, a membrane protein required for secretion of Shigella spp. Ipa invasins: involvement in entry into epithelial cells and in intercellular dissemination." Allaoui A., Sansonetti P.J., Menard R., Barzu S., Mounier J., Phalipon A., Parsot C. Mol. Microbiol. 17:461-470(1995) [PubMed: 8559065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-13. Strain: M90T / Serotype 5a.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M98390 Genomic DNA. Translation: AAA26530.1.
AL391753 Genomic DNA. Translation: CAC05812.1.
AF348706 Genomic DNA. Translation: AAK18456.1.
AF386526 Genomic DNA. Translation: AAL72553.1.
Z48957 Genomic DNA. Translation: CAA88823.1.

PIR

RefSeq

NP_085300.1. NC_002698.1.
NP_858270.1. NC_004851.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CA5	X-ray	2.10	A/B	1-78	[»]
2V6L	electron microscopy	16.00	0/1/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z	1-83	[»]

ProteinModelPortal

SMR

P0A223. Positions 15-75.

ModBase

Protein-protein interaction databases

DIP

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

EnsemblBacteria

EBESCT00000094187; EBESCP00000090394; EBESCG00000093231.

GeneID

1238256.
876534.

GenomeReviews

Gene locus CP0137 in contig AF386526_GR.

KEGG

Organism-specific databases

CMR

Phylogenomic databases

GeneTree

EBGT00050000010944.

HOGENOM

OMA

ProtClustDB

Family and domain databases

InterPro

IPR021123. T3SS_needle-like.
IPR011841. T3SS_needle_YscF.
[Graphical view]

KO

Pfam

PF09392. MxiH. 1 hit.
[Graphical view]

TIGRFAMs

TIGR02105. III_needle. 1 hit.

ProtoNet

Entry information

Entry name

MXIH_SHIFL

Accession

Primary (citable) accession number: P0A223
Secondary accession number(s): Q06079, Q6LAA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents