P0A1Y7 (NUOCD_SALTI) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 52.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: NADH-quinone oxidoreductase subunit C/D EC=1.6.99.5 Alternative name(s): NADH dehydrogenase I subunit C/D NDH-1 subunit C/D | ||||||
| Gene names |
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| Organism | Salmonella typhi [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 90370 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 596 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01359 |
| Catalytic activity | NADH + quinone = NAD+ + quinol. HAMAP MF_01359 |
| Subunit structure | NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex By similarity. |
| Subcellular location | Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP MF_01359. |
| Sequence similarities | In the N-terminal section; belongs to the complex I 30 kDa subunit family. In the C-terminal section; belongs to the complex I 49 kDa subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transport |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Ligand | NAD Ubiquinone |
| Molecular function | Oxidoreductase |
| PTM | Quinone |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | transport Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activityInferred from electronic annotation. Source: InterPro quinone bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | |||||
| Chain | 2 – 596 | 595 | NADH-quinone oxidoreductase subunit C/D HAMAP MF_01359 | PRO_0000118679 | ||||
Regions | ||||||||
| Region | 2 – 186 | 185 | NADH dehydrogenase I subunit C By similarity | |||||
| Region | 210 – 596 | 387 | NADH dehydrogenase I subunit D By similarity | |||||
Sequences
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References
| [1] | "Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. Barrell B.G.Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18. |
| [2] | "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL627274 Genomic DNA. Translation: CAD07558.1. AE014613 Genomic DNA. Translation: AAO68244.1. |
3D structure databases | |
| ProteinModelPortal | P0A1Y7. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P0A1Y7. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GenomeReviews | Gene locus t0538 in contig AE014613_GR. Gene locus STY2556 in contig AL513382_GR. |
| KEGG | stt:t0538. sty:STY2556. |
| PATRIC | 18543076. VBISalEnt120419_2586. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG459705. |
| OMA | PHLQQIP. |
| ProtClustDB | PRK11742. |
Enzyme and pathway databases | |
| BioCyc | SENT209261:T0538-MONOMER. SENT220341:STY2556-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01359. NDH1_NuoCD_1. [Tree] |
| InterPro | IPR010219. NADH_DH_1_suD. IPR010218. NADH_DH_suC. IPR023062. NADH_DH_suC/D. IPR001135. NADH_Q_OxRdtase_suD. IPR001268. NADH_UbQ_OxRdtase_30kDa_su. IPR014029. NADH_UbQ_OxRdtase_49kDa_CS. IPR022885. NDH1_su_D/H. [Graphical view] |
| KO | K13378. |
| Pfam | PF00329. Complex1_30kDa. 1 hit. PF00346. Complex1_49kDa. 1 hit. [Graphical view] |
| ProDom | PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01961. NuoC_fam. 1 hit. TIGR01962. NuoD. 1 hit. |
| PROSITE | PS00542. COMPLEX1_30K. False negative. PS00535. COMPLEX1_49K. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NUOCD_SALTI | ||||||||
| Accession | Primary (citable) accession number: P0A1Y7 Secondary accession number(s): P33902 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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