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Protein

NADH-quinone oxidoreductase subunit G

Gene

nuoG

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
  • [4Fe-4S] clusterBy similarityNote: Binds 3 [4Fe-4S] clusters per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi45Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi48Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi67Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi99Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi103Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi106Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi112Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi151Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi154Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi157Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi201Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi228Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi231Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi235Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi263Iron-sulfur 4 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit G (EC:1.6.5.11)
Alternative name(s):
NADH dehydrogenase I subunit G
NDH-1 subunit G
Gene namesi
Name:nuoG
Ordered Locus Names:STY2553, t0541
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001185532 – 908NADH-quinone oxidoreductase subunit GAdd BLAST907

Keywords - PTMi

Quinone

Proteomic databases

PRIDEiP0A1Y5

Interactioni

Subunit structurei

Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi220341.STY2553

Structurei

3D structure databases

ProteinModelPortaliP0A1Y5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 832Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST82
Domaini83 – 1224Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST40
Domaini221 – 2774Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Belongs to the complex I 75 kDa subunit family.Curated

Phylogenomic databases

eggNOGiENOG4107R0R Bacteria
COG1034 LUCA
HOGENOMiHOG000276177
KOiK00336
OMAiGYGYVNR

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR009010 Asp_de-COase-like_dom_sf
IPR006657 MoPterin_dinucl-bd_dom
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS
IPR010228 NADH_UbQ_OxRdtase_Gsu
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
PfamiView protein in Pfam
PF04879 Molybdop_Fe4S4, 1 hit
PF00384 Molybdopterin, 1 hit
PF01568 Molydop_binding, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTiView protein in SMART
SM00926 Molybdop_Fe4S4, 1 hit
SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR01973 NuoG, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit
PS00641 COMPLEX1_75K_1, 1 hit
PS00642 COMPLEX1_75K_2, 1 hit
PS00643 COMPLEX1_75K_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A1Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIHVDGKE YEVNGADNLL QACLSLGLDI PYFCWHPALG SVGACRQCAV
60 70 80 90 100
KQYQNAEDTR GRLVMSCMTP ATDGTFISID DEEAKQFRES VVEWLMTNHP
110 120 130 140 150
HDCPVCEEGG NCHLQDMTVM TGHSFRRYRF TKRTHRNQDL GPFISHEMNR
160 170 180 190 200
CIACYRCVRY YKDYADGTDL GVYGAHDNVY FGRPEDGTLE SEFSGNLVEI
210 220 230 240 250
CPTGVFTDKT HSERYNRKWD MQFAPSICQQ CSIGCNISPG ERYGELRRIE
260 270 280 290 300
NRYNGTVNHY FLCDRGRFGY GYVNLKDRPR QPVQRRGDDF ITLNAEQAMQ
310 320 330 340 350
GAADILRQSK KVIGIGSPRA SIESNFALRE LVGAENFYTG IARGEQERLQ
360 370 380 390 400
LALKVLREGG IYTPALREIE SYDAVLVLGE DVTQTGARVA LAVRQAVKGK
410 420 430 440 450
AREMAAAQKV ADWQIAAILN IGQRAKHPLF VTNVDDTRLD DIAAWTYRAP
460 470 480 490 500
VEDQARLGFA IAHALDNTAP AVDGIDSDLQ NKIDVIVQAL AGAKKPLIIS
510 520 530 540 550
GTNAGSSEVI QAAANVAKAL KGRGADVGIT MIARSVNSMG LGMMGGGSLD
560 570 580 590 600
DALGELETGS ADAVVVLEND LHRHASATRV NAALAKAPLV MVVDHQRTAI
610 620 630 640 650
MENAHLVLSA ASFAESDGTV INNEGRAQRF FQVYDPAYYD NKTIMLESWR
660 670 680 690 700
WLHSLHSTVE NREVDWTQLD HVIDAVIAAM PQFAGIKDAA PDATFRIRGQ
710 720 730 740 750
KLAREPHRYS GRTAMRANIS VHEPRQPQDK DTMFAFSMEG NNQPTAPRSE
760 770 780 790 800
IPFAWAPGWN SPQAWNKFQD EVGGKLRHGD PGVRLIEATE GGLDYFTTVP
810 820 830 840 850
ASFQAQDGQW RIAPYYHLFG SDELSQRSPV FQSRMPQPYI KLNPADAAKL
860 870 880 890 900
GVNAGTRVSF SYDGNTVTLP VEISEGLAAG QVGLPMGMPG IAPVLAGARL

EDLREAQQ
Length:908
Mass (Da):100,028
Last modified:January 23, 2007 - v2
Checksum:i6A4BAB18E60C20EC
GO

Sequence cautioni

The sequence AAO68247 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD07555 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti859S → F in AAO68247 (PubMed:12644504).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD07555.1 Different initiation.
AE014613 Genomic DNA Translation: AAO68247.1 Different initiation.
PIRiAI0796
RefSeqiNP_456865.1, NC_003198.1

Genome annotation databases

EnsemblBacteriaiAAO68247; AAO68247; t0541
CAD07555; CAD07555; CAD07555
GeneIDi1248878
KEGGistt:t0541
sty:STY2553
PATRICifig|220341.7.peg.2583

Similar proteinsi

Entry informationi

Entry nameiNUOG_SALTI
AccessioniPrimary (citable) accession number: P0A1Y5
Secondary accession number(s): P33900
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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