Reviewed,
UniProtKB/Swiss-Prot P0A1Y3 (ASRC_SALTI)
Last modified
February 9, 2010.
Version 40.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Anaerobic sulfite reductase subunit C EC=1.8.1.- | ||||
| Gene names |
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| Organism | Salmonella typhi [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 90370 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 337 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This enzyme catalyzes the hydrogen sulfide production from sulfite. It is strictly anaerobic. It is regulated by electron acceptors rather than by cysteine By similarity. |
| Catalytic activity | Hydrogen sulfide + 3 NAD+ + 3 H2O = sulfite + 3 NADH. |
| Cofactor | Binds 3 4Fe-4S clusters per subunit By similarity. Binds 1 siroheme per subunit By similarity. |
| Pathway | |
| Subunit structure | The anaerobic sulfite reductase seems to consist of three subunits By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. Contains 2 4Fe-4S ferredoxin-type domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Transport |
| Cellular component | Cytoplasm |
| Domain | Repeat |
| Ligand | 4Fe-4S Heme Iron Iron-sulfur Metal-binding NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activityInferred from electronic annotation. Source: InterPro heme bindingInferred from electronic annotation. Source: InterPro oxidoreductase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 337 | 337 | Anaerobic sulfite reductase subunit C | PRO_0000199964 | |||||
Regions | |||||||||
| Domain | 171 – 200 | 30 | 4Fe-4S ferredoxin-type 1 | ||||||
| Domain | 203 – 232 | 30 | 4Fe-4S ferredoxin-type 2 | ||||||
Sites | |||||||||
| Metal binding | 115 | 1 | Iron-sulfur 1 (4Fe-4S) By similarity | ||||||
| Metal binding | 121 | 1 | Iron-sulfur 1 (4Fe-4S) By similarity | ||||||
| Metal binding | 153 | 1 | Iron-sulfur 1 (4Fe-4S) By similarity | ||||||
| Metal binding | 157 | 1 | Iron (siroheme axial ligand) By similarity | ||||||
| Metal binding | 157 | 1 | Iron-sulfur 1 (4Fe-4S) By similarity | ||||||
| Metal binding | 180 | 1 | Iron-sulfur 2 (4Fe-4S) By similarity | ||||||
| Metal binding | 183 | 1 | Iron-sulfur 2 (4Fe-4S) By similarity | ||||||
| Metal binding | 186 | 1 | Iron-sulfur 2 (4Fe-4S) By similarity | ||||||
| Metal binding | 190 | 1 | Iron-sulfur 3 (4Fe-4S) By similarity | ||||||
| Metal binding | 212 | 1 | Iron-sulfur 3 (4Fe-4S) By similarity | ||||||
| Metal binding | 215 | 1 | Iron-sulfur 3 (4Fe-4S) By similarity | ||||||
| Metal binding | 218 | 1 | Iron-sulfur 3 (4Fe-4S) By similarity | ||||||
| Metal binding | 222 | 1 | Iron-sulfur 2 (4Fe-4S) By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. Barrell B.G.Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18. |
| [2] | "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL627275 Genomic DNA. Translation: CAD02753.1. AE014613 Genomic DNA. Translation: AAO68030.1. |
| RefSeq | NP_457081.1. NP_804181.1. |
3D structure databases | |
| SMR | P0A1Y3. Positions 20-326. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1067914. 1249106. |
| GenomeReviews | Gene locus t0306 in contig AE014613_GR. |
| KEGG | stt:t0306. sty:STY2796. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG419834. |
| OMA | GRTGKQT. |
Enzyme and pathway databases | |
| BioCyc | SENT209261:T0306-MONOMER. SENT220341:STY2796-MONOMER. |
Family and domain databases | |
| InterPro | IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR005117. NiRdtase/SiRdtase_haem-b_fer. IPR006067. NO2/SO3_Rdtase_4Fe4S_dom. IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS. IPR014261. Sulphite_reductase_C. [Graphical view] |
| Pfam | PF01077. NIR_SIR. 1 hit. PF03460. NIR_SIR_ferr. 1 hit. [Graphical view] |
| PRINTS | PR00397. SIROHAEM. |
| TIGRFAMs | TIGR02912. sulfite_red_C. 1 hit. |
| PROSITE | PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 2 hits. PS00365. NIR_SIR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ASRC_SALTI | ||||||||
| Accession | Primary (citable) accession number: P0A1Y3 Secondary accession number(s): P26476 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


