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Protein

Lipoprotein MxiM

Gene

mxiM

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the secretion of the Ipa antigens.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein MxiM
Gene namesi
Name:mxiM
Ordered Locus Names:CP0143
Encoded oniPlasmid pWR1003 Publications
Plasmid pINV_F6_M13821 Publication
Plasmid pCP3011 Publication
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
Proteomesi
  • UP000001006 Componenti: Plasmid pCP301

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323PROSITE-ProRule annotationAdd
BLAST
Chaini24 – 142119Lipoprotein MxiMPRO_0000018225Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi24 – 241N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi24 – 241S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP0A1X2.
PRIDEiP0A1X2.

Interactioni

Protein-protein interaction databases

DIPiDIP-46243N.
STRINGi198214.CP0143.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 407Combined sources
Helixi43 – 453Combined sources
Beta strandi53 – 564Combined sources
Turni58 – 603Combined sources
Beta strandi63 – 664Combined sources
Beta strandi68 – 736Combined sources
Beta strandi75 – 795Combined sources
Beta strandi82 – 865Combined sources
Helixi98 – 11316Combined sources
Beta strandi115 – 1184Combined sources
Beta strandi121 – 1244Combined sources
Beta strandi126 – 1305Combined sources
Beta strandi133 – 1408Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y9LX-ray1.50A28-142[»]
1Y9TX-ray1.87A28-142[»]
2JW1NMR-A28-142[»]
ProteinModelPortaliP0A1X2.
SMRiP0A1X2. Positions 33-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A1X2.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000034768.
OMAiGERQMIR.
OrthoDBiEOG6R5C87.

Family and domain databases

InterProiIPR021546. MxiM.
[Graphical view]
PfamiPF11441. MxiM. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A1X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRHGSNKLK IFILSILLLT LSGCALKSSS NSEKEWHIVP VSKDYFSIPN
60 70 80 90 100
DLLWSFNTTN KSINVYSKCI SGKAVYSFNA GKFMGNFNVK EVDGCFMDAQ
110 120 130 140
KIAIDKLFSM LKDGVVLKGN KINDTILIEK DGEVKLKLIR GI
Length:142
Mass (Da):15,853
Last modified:March 1, 2005 - v1
Checksum:i20D30F76A3EF9B16
GO

Sequence cautioni

The sequence AAK18462.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98391 Genomic DNA. Translation: AAA26534.1.
AL391753 Genomic DNA. Translation: CAC05818.1.
AF348706 Genomic DNA. Translation: AAK18462.1. Different initiation.
AY206439 Genomic DNA. Translation: AAP79006.1.
AF386526 Genomic DNA. Translation: AAL72325.2.
PIRiE45271.
RefSeqiNP_858276.2. NC_004851.1.
WP_001346200.1. NZ_JWSL01000003.1.
YP_009062500.1. NC_024996.1.

Genome annotation databases

EnsemblBacteriaiAAL72325; AAL72325; SF_p0143.
KEGGipg:20467587.
sfl:CP0143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98391 Genomic DNA. Translation: AAA26534.1.
AL391753 Genomic DNA. Translation: CAC05818.1.
AF348706 Genomic DNA. Translation: AAK18462.1. Different initiation.
AY206439 Genomic DNA. Translation: AAP79006.1.
AF386526 Genomic DNA. Translation: AAL72325.2.
PIRiE45271.
RefSeqiNP_858276.2. NC_004851.1.
WP_001346200.1. NZ_JWSL01000003.1.
YP_009062500.1. NC_024996.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y9LX-ray1.50A28-142[»]
1Y9TX-ray1.87A28-142[»]
2JW1NMR-A28-142[»]
ProteinModelPortaliP0A1X2.
SMRiP0A1X2. Positions 33-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46243N.
STRINGi198214.CP0143.

Proteomic databases

PaxDbiP0A1X2.
PRIDEiP0A1X2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL72325; AAL72325; SF_p0143.
KEGGipg:20467587.
sfl:CP0143.

Phylogenomic databases

HOGENOMiHOG000034768.
OMAiGERQMIR.
OrthoDBiEOG6R5C87.

Miscellaneous databases

EvolutionaryTraceiP0A1X2.

Family and domain databases

InterProiIPR021546. MxiM.
[Graphical view]
PfamiPF11441. MxiM. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins."
    Allaoui A., Sansonetti P.J., Parsot C.
    J. Bacteriol. 174:7661-7669(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M90T / Serotype 5a.
    Plasmid: pWR100
  2. "The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri."
    Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H., Kunst F., Sansonetti P.J., Parsot C.
    Mol. Microbiol. 38:760-771(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M90T / Serotype 5a.
    Plasmid: pWR100
  3. "Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri."
    Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V., Blattner F.R.
    Infect. Immun. 69:3271-3285(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M90T / Serotype 5a.
    Plasmid: pWR100
  4. "Comparison of two major forms of the Shigella virulence plasmid pINV: positive selection is a major force driving the divergence."
    Lan R., Stevenson G., Reeves P.R.
    Infect. Immun. 71:6298-6306(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M1382 / Serotype 6.
    Plasmid: pINV_F6_M1382
  5. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
    Plasmid: pCP301

Entry informationi

Entry nameiMXIM_SHIFL
AccessioniPrimary (citable) accession number: P0A1X2
Secondary accession number(s): Q06083, Q9AFS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.