P0A1W6 (LIVK_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-specific-binding protein
Short name=L-BP
Short name=LS-BP

Gene names

Name:	livK
Synonyms:	livC
Ordered Locus Names:	STM3564

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the leucine-binding protein family.

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Periplasm
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	amino acid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23
	Chain	24 – 369	346	Leucine-specific-binding protein		PRO_0000017704
Amino acid modifications
	Disulfide bond	76 ↔ 101		By similarity
Experimental info
	Sequence conflict	232 – 233	2	ML → IV in BAA00370. Ref.1
	Sequence conflict	321	1	A → R in BAA00370. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P0A1W6 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 752D7CC79369BBCA	FASTA	369	39,401
	10 20 30 40 50 60 MKRKAKTIIA GIVALAVSQG AMADDIKVAI VGAMSGPVAQ WGDMEFNGAR QAIKDINAKG 70 80 90 100 110 120 GIKGDKLVGV EYDDACDPKQ AVAVANKIVN DGIQYVIGHL CSSSTQPASD IYEDEGILMI 130 140 150 160 170 180 SPGATNPELT QRGYQYIMRT AGLDSSQGPT AAKYILETVK PQRIAIIHDK QQYGEGLARS 190 200 210 220 230 240 VQDGLKQGNA NIVFFDGITA GEKDFSALIA RLQKENIDFV YYGGYYPEMG QMLRQARANG 250 260 270 280 290 300 LKTQFMGPEG VGNASLSNIA GGAAEGMLVT MPKRYDQDPA NKAIVEALKA DKKDPSGPYV 310 320 330 340 350 360 WITYAAVQSL ATAMTRSASH APLDLVKDLK ANGADTVIGP LKWDEKGDLK GFEFGVFQWH ADGSSTVAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and nucleotide sequences of livB and livC, the structural genes encoding binding proteins of the high-affinity branched-chain amino acid transport in Salmonella typhimurium." Ohnishi K., Nakazima A., Matsubara K., Kiritani K. J. Biochem. 107:202-208(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 25-40. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D00478 Genomic DNA. Translation: BAA00370.1. AE006468 Genomic DNA. Translation: AAL22424.1.
PIR	JU0129.
RefSeq	NP_462465.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P0A1W6.
SMR	P0A1W6. Positions 24-368.
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM3564.
Proteomic databases
PaxDb	P0A1W6.
PRIDE	P0A1W6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL22424; AAL22424; STM3564.
GeneID	1255087.
KEGG	stm:STM3564.
PATRIC	32385939. VBISalEnt20916_3767.
Phylogenomic databases
eggNOG	COG0683.
HOGENOM	HOG000130989.
KO	K01999.
OMA	ATQHHEW.
ProtClustDB	PRK15404.
Family and domain databases
InterPro	IPR000709. Leu_Ile_Val-bd. [Graphical view]
PRINTS	PR00337. LEUILEVALBP.
ProtoNet	Search...

Entry information

Entry name

LIVK_SALTY

Accession

Primary (citable) accession number: P0A1W6
Secondary accession number(s): P17216

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program