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P0A1V9 (BLO2_ECOLX) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase OXA-2

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:bla
Synonyms:oxa2
Encoded onPlasmid IncN R46
OrganismEscherichia coli
Taxonomic identifier562 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This is an oxacillin-hydrolyzing beta-lactamase.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-D beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

penicillin binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 275254Beta-lactamase OXA-2
PRO_0000017025

Regions

Region210 – 2123Substrate binding By similarity

Sites

Active site721Acyl-ester intermediate By similarity

Amino acid modifications

Modified residue751N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A1V9 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: D3678DFCB78DE8B6

FASTA27531,686
        10         20         30         40         50         60 
MAIRIFAILF SIFSLATFAH AQEGTLERSD WRKFFSEFQA KGTIVVADER QADRAMLVFD 

        70         80         90        100        110        120 
PVRSKKRYSP ASTFKIPHTL FALDAGAVRD EFQIFRWDGV NRGFAGHNQD QDLRSAMRNS 

       130        140        150        160        170        180 
TVWVYELFAK EIGDDKARRY LKKIDYGNAD PSTSNGDYWI EGSLAISAQE QIAFLRKLYR 

       190        200        210        220        230        240 
NELPFRVEHQ RLVKDLMIVE AGRNWILRAK TGWEGRMGWW VGWVEWPTGS VFFALNIDTP 

       250        260        270 
NRMDDLFKRE AIVRAILRSI EALPPNPAVN SDAAR 

« Hide

References

[1]"The region of the IncN plasmid R46 coding for resistance to beta-lactam antibiotics, streptomycin/spectinomycin and sulphonamides is closely related to antibiotic resistance segments found in IncW plasmids and in Tn21-like transposons."
Hall R.M., Vockler C.
Nucleic Acids Res. 15:7491-7501(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The integron In1 in plasmid R46 includes two copies of the oxa2 gene cassette."
Stokes H.W., Hall R.M.
Plasmid 28:225-234(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95287 Genomic DNA. Translation: AAB59082.1.
M95287 Genomic DNA. Translation: AAB59084.2.
RefSeqYP_006953608.1. NC_019081.1.

3D structure databases

ProteinModelPortalP0A1V9.
SMRP0A1V9. Positions 25-265.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL1744485.

Proteomic databases

PRIDEP0A1V9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID13906543.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLO2_ECOLX
AccessionPrimary (citable) accession number: P0A1V9
Secondary accession number(s): P05191, Q57015
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: December 11, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families