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Protein

Beta-lactamase OXA-2

Gene

bla

Organism
Salmonella typhimurium
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is an oxacillin-hydrolyzing beta-lactamase.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-2 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
Synonyms:oxa2
Encoded oniPlasmid IncN R463 Publications
Plasmid pBP111 Publication
OrganismiSalmonella typhimurium
Taxonomic identifieri90371 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001702622 – 275Beta-lactamase OXA-2Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75N6-carboxylysine1 Publication1

Proteomic databases

PRIDEiP0A1V8.

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 31Combined sources3
Helixi32 – 37Combined sources6
Beta strandi42 – 48Combined sources7
Beta strandi50 – 53Combined sources4
Beta strandi57 – 60Combined sources4
Helixi61 – 64Combined sources4
Helixi71 – 74Combined sources4
Helixi75 – 84Combined sources10
Turni105 – 107Combined sources3
Helixi113 – 118Combined sources6
Helixi122 – 132Combined sources11
Helixi134 – 143Combined sources10
Turni158 – 160Combined sources3
Beta strandi161 – 163Combined sources3
Helixi168 – 179Combined sources12
Beta strandi183 – 185Combined sources3
Helixi187 – 196Combined sources10
Beta strandi198 – 202Combined sources5
Beta strandi205 – 226Combined sources22
Beta strandi229 – 238Combined sources10
Helixi242 – 247Combined sources6
Helixi248 – 259Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K38X-ray1.50A/B22-275[»]
ProteinModelPortaliP0A1V8.
SMRiP0A1V8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A1V8.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 212Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK18791.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A1V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRIFAILF SIFSLATFAH AQEGTLERSD WRKFFSEFQA KGTIVVADER
60 70 80 90 100
QADRAMLVFD PVRSKKRYSP ASTFKIPHTL FALDAGAVRD EFQIFRWDGV
110 120 130 140 150
NRGFAGHNQD QDLRSAMRNS TVWVYELFAK EIGDDKARRY LKKIDYGNAD
160 170 180 190 200
PSTSNGDYWI EGSLAISAQE QIAFLRKLYR NELPFRVEHQ RLVKDLMIVE
210 220 230 240 250
AGRNWILRAK TGWEGRMGWW VGWVEWPTGS VFFALNIDTP NRMDDLFKRE
260 270
AIVRAILRSI EALPPNPAVN SDAAR
Length:275
Mass (Da):31,686
Last modified:August 13, 1987 - v1
Checksum:iD3678DFCB78DE8B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25261 Genomic DNA. Translation: AAA98357.1.
X03037 Genomic DNA. Translation: CAA26839.1.
X07260 Genomic DNA. Translation: CAA30246.1.
PIRiA91350. PNEBT.
RefSeqiNP_511223.1. NC_003292.1.
NP_511225.1. NC_003292.1.
WP_001007673.1. NG_049496.1.

Genome annotation databases

GeneIDi1263131.
1263136.
KEGGiag:CAA30246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25261 Genomic DNA. Translation: AAA98357.1.
X03037 Genomic DNA. Translation: CAA26839.1.
X07260 Genomic DNA. Translation: CAA30246.1.
PIRiA91350. PNEBT.
RefSeqiNP_511223.1. NC_003292.1.
NP_511225.1. NC_003292.1.
WP_001007673.1. NG_049496.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K38X-ray1.50A/B22-275[»]
ProteinModelPortaliP0A1V8.
SMRiP0A1V8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP0A1V8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1263131.
1263136.
KEGGiag:CAA30246.

Phylogenomic databases

KOiK18791.

Miscellaneous databases

EvolutionaryTraceiP0A1V8.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBLO2_SALTM
AccessioniPrimary (citable) accession number: P0A1V8
Secondary accession number(s): P05191, Q57015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.