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Protein

Beta-lactamase OXA-2

Gene

bla

Organism
Salmonella typhimurium
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is an oxacillin-hydrolyzing beta-lactamase.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-2 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
Synonyms:oxa2
Encoded oniPlasmid IncN R463 Publications
Plasmid pBP111 Publication
OrganismiSalmonella typhimurium
Taxonomic identifieri90371 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

Pathology & Biotechi

Chemistry databases

DrugBankiDB01942 Formic Acid
DB03801 Lysine Nz-Carboxylic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001702622 – 275Beta-lactamase OXA-2Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75N6-carboxylysine1 Publication1

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 31Combined sources3
Helixi32 – 37Combined sources6
Beta strandi42 – 48Combined sources7
Beta strandi50 – 53Combined sources4
Beta strandi57 – 60Combined sources4
Helixi61 – 64Combined sources4
Helixi71 – 74Combined sources4
Helixi75 – 84Combined sources10
Turni105 – 107Combined sources3
Helixi113 – 118Combined sources6
Helixi122 – 132Combined sources11
Helixi134 – 143Combined sources10
Turni158 – 160Combined sources3
Beta strandi161 – 163Combined sources3
Helixi168 – 179Combined sources12
Beta strandi183 – 185Combined sources3
Helixi187 – 196Combined sources10
Beta strandi198 – 202Combined sources5
Beta strandi205 – 226Combined sources22
Beta strandi229 – 238Combined sources10
Helixi242 – 247Combined sources6
Helixi248 – 259Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K38X-ray1.50A/B22-275[»]
ProteinModelPortaliP0A1V8
SMRiP0A1V8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A1V8

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 212Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK18791

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR002137 Beta-lactam_class-D_AS
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00337 BETA_LACTAMASE_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A1V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRIFAILF SIFSLATFAH AQEGTLERSD WRKFFSEFQA KGTIVVADER
60 70 80 90 100
QADRAMLVFD PVRSKKRYSP ASTFKIPHTL FALDAGAVRD EFQIFRWDGV
110 120 130 140 150
NRGFAGHNQD QDLRSAMRNS TVWVYELFAK EIGDDKARRY LKKIDYGNAD
160 170 180 190 200
PSTSNGDYWI EGSLAISAQE QIAFLRKLYR NELPFRVEHQ RLVKDLMIVE
210 220 230 240 250
AGRNWILRAK TGWEGRMGWW VGWVEWPTGS VFFALNIDTP NRMDDLFKRE
260 270
AIVRAILRSI EALPPNPAVN SDAAR
Length:275
Mass (Da):31,686
Last modified:August 13, 1987 - v1
Checksum:iD3678DFCB78DE8B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25261 Genomic DNA Translation: AAA98357.1
X03037 Genomic DNA Translation: CAA26839.1
X07260 Genomic DNA Translation: CAA30246.1
PIRiA91350 PNEBT
RefSeqiNP_511223.1, NC_003292.1
NP_511225.1, NC_003292.1
WP_001007673.1, NG_049496.1

Genome annotation databases

GeneIDi1263131
1263136
32364981
KEGGiag:CAA30246

Similar proteinsi

Entry informationi

Entry nameiBLO2_SALTM
AccessioniPrimary (citable) accession number: P0A1V8
Secondary accession number(s): P05191, Q57015
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid

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