Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Trehalose-6-phosphate synthase

Gene

otsA

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor.By similarity

Catalytic activityi

UDP-alpha-D-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.By similarity

Pathwayi: trehalose biosynthesis

This protein is involved in the pathway trehalose biosynthesis, which is part of Glycan biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway trehalose biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10D-glucose 6-phosphateBy similarity1
Binding sitei76D-glucose 6-phosphateBy similarity1
Sitei85Involved in alpha anomer selectivityBy similarity1
Binding sitei130D-glucose 6-phosphateBy similarity1
Sitei155Involved in alpha anomer selectivityBy similarity1
Binding sitei262UDP-glucoseBy similarity1
Binding sitei267UDP-glucoseBy similarity1
Binding sitei300D-glucose 6-phosphateBy similarity1
Binding sitei339UDP-glucose; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00299

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalose-6-phosphate synthaseBy similarity (EC:2.4.1.15By similarity)
Short name:
TPSBy similarity
Alternative name(s):
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]By similarity
Osmoregulatory trehalose synthesis protein ABy similarity
Short name:
OtsABy similarity
UDP-glucose-glucosephosphate glucosyltransferaseBy similarity
Gene namesi
Name:otsABy similarity
Ordered Locus Names:STY2137, t0949
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001224922 – 473Trehalose-6-phosphate synthaseAdd BLAST472

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi220341.STY2137

Structurei

3D structure databases

ProteinModelPortaliP0A1Q1
SMRiP0A1Q1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 22UDP-glucose bindingBy similarity2
Regioni365 – 369UDP-glucose bindingBy similarity5

Sequence similaritiesi

Belongs to the glycosyltransferase 20 family.By similarity

Phylogenomic databases

eggNOGiENOG4105C1K Bacteria
COG0380 LUCA
HOGENOMiHOG000191478
KOiK00697
OMAiIEFMPIH

Family and domain databases

CDDicd03788 GT1_TPS, 1 hit
InterProiView protein in InterPro
IPR001830 Glyco_trans_20
IPR012766 Trehalose_OtsA
PfamiView protein in Pfam
PF00982 Glyco_transf_20, 1 hit
TIGRFAMsiTIGR02400 trehalose_OtsA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A1Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLVVVSNR IAPPDNKGGA GGLAVGVLGA LKAAGGLWFG WSGETGNEDE
60 70 80 90 100
PLKKVTKGNI TWASFNLSEQ DYEDYYCQFS NAVLWPAFHY RLDLVQFQRP
110 120 130 140 150
AWEGYMRVNA LLADKLLPLI KENDIIWVHD YHLLPFASEL RKRGVNNRIG
160 170 180 190 200
FFLHIPFPTP EIFNALPPHD ELLEQLCDFD LLGFQTENDR LAFLDSLSSQ
210 220 230 240 250
TRVTTRSGKQ HIAWGKDFQT EVYPIGIEPD EIALQAAGPL PPKLAQLKAE
260 270 280 290 300
LKNVKNIFSV ERLDYSKGLP ERFLAYEALL ENYPQHRGKI RYTQIAPTSR
310 320 330 340 350
GEVQAYQDIR HQLETEAGRI NGKYGQLGWT PLYYLNQHFD RKLLMKIFRY
360 370 380 390 400
SDVGLVTPLR DGMNLVAKEF VAAQDPANPG VLVLSQFAGA ANELTSALIV
410 420 430 440 450
NPYDRDDVAA ALNRALTMPL AERISRHAEM LDVIVKNDIN RWQERFIHDL
460 470
KEVTPRSPER QQQNNVATFP KLA
Length:473
Mass (Da):53,581
Last modified:January 23, 2007 - v2
Checksum:iE85B3F0AE58E144A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD05679.1
AE014613 Genomic DNA Translation: AAO68622.1
RefSeqiNP_456494.1, NC_003198.1
WP_000089042.1, NZ_PHKG01000001.1

Genome annotation databases

EnsemblBacteriaiAAO68622; AAO68622; t0949
CAD05679; CAD05679; CAD05679
GeneIDi1248479
KEGGistt:t0949
sty:STY2137
PATRICifig|220341.7.peg.2149

Similar proteinsi

Entry informationi

Entry nameiOTSA_SALTI
AccessioniPrimary (citable) accession number: P0A1Q1
Secondary accession number(s): Q9L893
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health