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P0A1Q1

- OTSA_SALTI

UniProt

P0A1Q1 - OTSA_SALTI

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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene
otsA, STY2137, t0949
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of glucose from UDP-glucose to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor By similarity.

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Glucose-6-phosphate By similarity
Binding sitei76 – 761Glucose-6-phosphate By similarity
Sitei85 – 851Involved in alpha anomer selectivity By similarity
Binding sitei130 – 1301Glucose-6-phosphate By similarity
Sitei155 – 1551Involved in alpha anomer selectivity By similarity
Binding sitei262 – 2621UDP-glucose By similarity
Binding sitei267 – 2671UDP-glucose By similarity
Binding sitei300 – 3001Glucose-6-phosphate By similarity
Binding sitei339 – 3391UDP-glucose; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00299.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
Osmoregulatory trehalose synthesis protein A
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:otsA
Ordered Locus Names:STY2137, t0949
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 473472Alpha,alpha-trehalose-phosphate synthase [UDP-forming]PRO_0000122492Add
BLAST

Proteomic databases

PRIDEiP0A1Q1.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi220341.STY2137.

Structurei

3D structure databases

ProteinModelPortaliP0A1Q1.
SMRiP0A1Q1. Positions 2-456.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 222UDP-glucose binding By similarity
Regioni365 – 3695UDP-glucose binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000191478.
KOiK00697.
OMAiWGESFVK.
OrthoDBiEOG6CCH1M.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A1Q1-1 [UniParc]FASTAAdd to Basket

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MSRLVVVSNR IAPPDNKGGA GGLAVGVLGA LKAAGGLWFG WSGETGNEDE    50
PLKKVTKGNI TWASFNLSEQ DYEDYYCQFS NAVLWPAFHY RLDLVQFQRP 100
AWEGYMRVNA LLADKLLPLI KENDIIWVHD YHLLPFASEL RKRGVNNRIG 150
FFLHIPFPTP EIFNALPPHD ELLEQLCDFD LLGFQTENDR LAFLDSLSSQ 200
TRVTTRSGKQ HIAWGKDFQT EVYPIGIEPD EIALQAAGPL PPKLAQLKAE 250
LKNVKNIFSV ERLDYSKGLP ERFLAYEALL ENYPQHRGKI RYTQIAPTSR 300
GEVQAYQDIR HQLETEAGRI NGKYGQLGWT PLYYLNQHFD RKLLMKIFRY 350
SDVGLVTPLR DGMNLVAKEF VAAQDPANPG VLVLSQFAGA ANELTSALIV 400
NPYDRDDVAA ALNRALTMPL AERISRHAEM LDVIVKNDIN RWQERFIHDL 450
KEVTPRSPER QQQNNVATFP KLA 473
Length:473
Mass (Da):53,581
Last modified:January 23, 2007 - v2
Checksum:iE85B3F0AE58E144A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD05679.1.
AE014613 Genomic DNA. Translation: AAO68622.1.
RefSeqiNP_456494.1. NC_003198.1.
NP_804773.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO68622; AAO68622; t0949.
CAD05679; CAD05679; CAD05679.
GeneIDi1248479.
KEGGisty:STY2137.
PATRICi18542183. VBISalEnt120419_2149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD05679.1 .
AE014613 Genomic DNA. Translation: AAO68622.1 .
RefSeqi NP_456494.1. NC_003198.1.
NP_804773.1. NC_004631.1.

3D structure databases

ProteinModelPortali P0A1Q1.
SMRi P0A1Q1. Positions 2-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY2137.

Proteomic databases

PRIDEi P0A1Q1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO68622 ; AAO68622 ; t0949 .
CAD05679 ; CAD05679 ; CAD05679 .
GeneIDi 1248479.
KEGGi sty:STY2137.
PATRICi 18542183. VBISalEnt120419_2149.

Phylogenomic databases

HOGENOMi HOG000191478.
KOi K00697.
OMAi WGESFVK.
OrthoDBi EOG6CCH1M.

Enzyme and pathway databases

UniPathwayi UPA00299 .

Family and domain databases

InterProi IPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02400. trehalose_OtsA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiOTSA_SALTI
AccessioniPrimary (citable) accession number: P0A1Q1
Secondary accession number(s): Q9L893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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