P0A1P9 (GLRX1_SALTI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutaredoxin-1
Short name=Grx1

Gene names

Name:	grxA
Ordered Locus Names:	STY0905, t2024

Organism

Salmonella typhi [Complete proteome] [HAMAP]

Taxonomic identifier

90370 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase By similarity.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Deoxyribonucleotide synthesis Electron transport Transport
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro deoxyribonucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 87	87	Glutaredoxin-1		PRO_0000141582
Regions
	Domain	1 – 87	87	Glutaredoxin
Amino acid modifications
	Disulfide bond	11 ↔ 14		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A1P9 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 9BDE71DE3CFF6B7B	FASTA	87	9,924
	10 20 30 40 50 60 MFTVIFGRPG CPYCVRAKEL AEKLSKERDD FNYRYIDIHA EGITKADLEK TVGKPVETVP 70 80 QIFVDQKHIG GCTDFEAWAK ENLNLFA

References

[1]	"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18.
[2]	"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18." Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R. J. Bacteriol. 185:2330-2337(2003) [PubMed: 12644504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700931 / Ty2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL627268 Genomic DNA. Translation: CAD05311.1. AE014613 Genomic DNA. Translation: AAO69636.1.
RefSeq	NP_455399.1. NC_003198.1. NP_805787.1. NC_004631.1.
3D structure databases
ProteinModelPortal	P0A1P9.
SMR	P0A1P9. Positions 1-84.
ModBase	Search...
Proteomic databases
PRIDE	P0A1P9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1069091. 1247343.
GenomeReviews	Gene locus t2024 in contig AE014613_GR. Gene locus STY0905 in contig AL513382_GR.
KEGG	stt:t2024. sty:STY0905.
PATRIC	18539689. VBISalEnt120419_0914.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG728471.
OMA	VGGCTEF.
ProtClustDB	PRK11200.
Enzyme and pathway databases
BioCyc	SENT209261:T2024-MONOMER. SENT220341:STY0905-MONOMER.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR014025. Glutaredoxin_subgr. IPR011902. GRXA. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K03674.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR02183. GRXA. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX1_SALTI

Accession

Primary (citable) accession number: P0A1P9
Secondary accession number(s): Q9Z5Z3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program