Reviewed, UniProtKB/Swiss-Prot P0A1P8 (GLRX1_SALTY)

Names and origin

Protein names

Recommended name:
    Glutaredoxin-1
      Short name=Grx1

Gene names

Name:	grxA
Ordered Locus Names:	STM0872

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase By similarity.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Deoxyribonucleotide synthesis Electron transport Transport
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro deoxyribonucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 87	87	Glutaredoxin-1		PRO_0000141583
Regions
	Domain	1 – 87	87	Glutaredoxin
Amino acid modifications
	Disulfide bond	11 ↔ 14		Redox-active By similarity
Experimental info
	Sequence conflict	50 – 53	4	KTVG → QNRS in AAD18026. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P0A1P8-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 9BDE71DE3CFF6B7B	FASTA	87	9,924
	10 20 30 40 50 60 MFTVIFGRPG CPYCVRAKEL AEKLSKERDD FNYRYIDIHA EGITKADLEK TVGKPVETVP 70 80 QIFVDQKHIG GCTDFEAWAK ENLNLFA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the major nitrotreductase from Salmonella typhimurium TA1535." Lambert I.B., Boroumandi S., Nokhbeh M.R., Pokorny N.S., Koziarz P. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 29629 / TA 1535.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF117952 Genomic DNA. Translation: AAD18026.1. AE008736 Genomic DNA. Translation: AAL19808.1.
RefSeq	NP_459849.1.
3D structure databases
HSSP	HSSP built from PDB template 1EGO based on UniProtKB P00277.
SMR	P0A1P8. Positions 1-84.
ModBase	Search...
Genome annotation databases
GeneID	1252391.
GenomeReviews	Gene locus STM0872 in contig AE006468_GR.
KEGG	stm:STM0872.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0A1P8.
OMA	P0A1P8. KYVDIHA.
Enzyme and pathway databases
BioCyc	STYP99287:STM0872-MON.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR014025. Glutaredoxin_sub. IPR011902. GRXA. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
TIGRFAMs	TIGR02183. GRXA. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX1_SALTY

Accession

Primary (citable) accession number: P0A1P8
Secondary accession number(s): Q9Z5Z3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)