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Protein

Flagellar protein FliT

Gene

fliT

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.4 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Repressor

Keywords - Biological processi

Bacterial flagellum biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1973-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar protein FliT
Gene namesi
Name:fliT
Ordered Locus Names:STM1962
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 122122Flagellar protein FliTPRO_0000180977Add
BLAST

Proteomic databases

PaxDbiP0A1N2.
PRIDEiP0A1N2.

Interactioni

Subunit structurei

Homodimer. Interacts with FliD and FlhC.2 Publications

Protein-protein interaction databases

DIPiDIP-60504N.
STRINGi99287.STM1962.

Structurei

Secondary structure

1
122
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2723Combined sources
Helixi30 – 4819Combined sources
Helixi58 – 9336Combined sources
Helixi97 – 11014Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A7MX-ray3.20A/B1-122[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A1N2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5050Required for homodimerizationAdd
BLAST
Regioni60 – 9839FliD bindingAdd
BLAST

Sequence similaritiesi

Belongs to the FliT family.Curated

Phylogenomic databases

eggNOGiENOG4105YXP. Bacteria.
ENOG41124U3. LUCA.
HOGENOMiHOG000266968.
KOiK02423.
OMAiDMEITYL.

Family and domain databases

HAMAPiMF_01180. FliT. 1 hit.
InterProiIPR008622. FliT.
[Graphical view]
PfamiPF05400. FliT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A1N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTVEFINR WQRIALLSQS LLELAQRGEW DLLLQQEVSY LQSIETVMEK
60 70 80 90 100
QTPPGITRSI QDMVAGYIKQ TLDNEQLLKG LLQQRLDELS SLIGQSTRQK
110 120
SLNNAYGRLS GMLLVPDAPG AS
Length:122
Mass (Da):13,705
Last modified:March 15, 2005 - v1
Checksum:iCF622E06DCD122AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85241 Genomic DNA. Translation: AAA27078.1.
L01643 Genomic DNA. Translation: AAA27109.1.
AE006468 Genomic DNA. Translation: AAL20874.1.
RefSeqiNP_460915.1. NC_003197.1.
WP_000204899.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20874; AAL20874; STM1962.
GeneIDi1253483.
KEGGistm:STM1962.
PATRICi32382485. VBISalEnt20916_2078.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85241 Genomic DNA. Translation: AAA27078.1.
L01643 Genomic DNA. Translation: AAA27109.1.
AE006468 Genomic DNA. Translation: AAL20874.1.
RefSeqiNP_460915.1. NC_003197.1.
WP_000204899.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A7MX-ray3.20A/B1-122[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60504N.
STRINGi99287.STM1962.

Proteomic databases

PaxDbiP0A1N2.
PRIDEiP0A1N2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20874; AAL20874; STM1962.
GeneIDi1253483.
KEGGistm:STM1962.
PATRICi32382485. VBISalEnt20916_2078.

Phylogenomic databases

eggNOGiENOG4105YXP. Bacteria.
ENOG41124U3. LUCA.
HOGENOMiHOG000266968.
KOiK02423.
OMAiDMEITYL.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1973-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A1N2.

Family and domain databases

HAMAPiMF_01180. FliT. 1 hit.
InterProiIPR008622. FliT.
[Graphical view]
PfamiPF05400. FliT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLIT_SALTY
AccessioniPrimary (citable) accession number: P0A1N2
Secondary accession number(s): P26611
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.