ID MXIA_SHIFL Reviewed; 686 AA. AC P0A1I5; P35533; Q55295; DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2005, sequence version 1. DT 27-MAR-2024, entry version 112. DE RecName: Full=Protein MxiA; DE AltName: Full=Protein VirH; GN Name=mxiA; Synonyms=virH; OrderedLocusNames=CP0147; OS Shigella flexneri. OG Plasmid pWR100, Plasmid pWR501, Plasmid pMYSH6000, and Plasmid pCP301. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Shigella. OX NCBI_TaxID=623; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 700930 / 2457T / Serotype 2a; PLASMID=pWR100; RX PubMed=1639496; DOI=10.1128/iai.60.8.3287-3295.1992; RA Andrews G.P., Maurelli A.T.; RT "mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid RT antigens, encodes a homolog of the low-calcium-response protein, LcrD, of RT Yersinia pestis."; RL Infect. Immun. 60:3287-3295(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=YSH6000 / Serotype 2a; PLASMID=pMYSH6000; RA Sasakawa C.; RT "A virulence locus, virH, on the large plasmid of Shigella flexneri."; RL Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=M90T / Serotype 5a; PLASMID=pWR100; RX PubMed=11115111; DOI=10.1046/j.1365-2958.2000.02179.x; RA Buchrieser C., Glaser P., Rusniok C., Nedjari H., d'Hauteville H., RA Kunst F., Sansonetti P.J., Parsot C.; RT "The virulence plasmid pWR100 and the repertoire of proteins secreted by RT the type III secretion apparatus of Shigella flexneri."; RL Mol. Microbiol. 38:760-771(2000). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=M90T / Serotype 5a; PLASMID=pWR501; RX PubMed=11292750; DOI=10.1128/iai.69.5.3271-3285.2001; RA Venkatesan M.M., Goldberg M.B., Rose D.J., Grotbeck E.J., Burland V., RA Blattner F.R.; RT "Complete DNA sequence and analysis of the large virulence plasmid of RT Shigella flexneri."; RL Infect. Immun. 69:3271-3285(2001). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=301 / Serotype 2a; PLASMID=pCP301; RX PubMed=12384590; DOI=10.1093/nar/gkf566; RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.; RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity RT through comparison with genomes of Escherichia coli K12 and O157."; RL Nucleic Acids Res. 30:4432-4441(2002). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 489-686. RC STRAIN=M90T / Serotype 5a; PLASMID=pWR100; RX PubMed=1312536; DOI=10.1128/jb.174.6.1990-2001.1992; RA Venkatesan M.M., Buysse J.M., Oaks E.V.; RT "Surface presentation of Shigella flexneri invasion plasmid antigens RT requires the products of the spa locus."; RL J. Bacteriol. 174:1990-2001(1992). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 489-686. RC STRAIN=YSH6000 / Serotype 2a; PLASMID=pMYSH6000; RX PubMed=8385666; DOI=10.1128/jb.175.8.2334-2346.1993; RA Sasakawa C., Komatsu K., Tobe T., Suzuki T., Yoshikawa M.; RT "Eight genes in region 5 that form an operon are essential for invasion of RT epithelial cells by Shigella flexneri 2a."; RL J. Bacteriol. 175:2334-2346(1993). CC -!- FUNCTION: Necessary for the secretion of IPA invasins. CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export CC pore) family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAA26529.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M91664; AAA26529.1; ALT_INIT; Genomic_DNA. DR EMBL; D10999; BAA01771.1; -; Genomic_DNA. DR EMBL; AL391753; CAC05822.1; -; Genomic_DNA. DR EMBL; AF348706; AAK18466.1; -; Genomic_DNA. DR EMBL; AF386526; AAL72333.1; -; Genomic_DNA. DR EMBL; M81458; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PIR; A44797; A44797. DR RefSeq; NP_085310.1; NC_002698.1. DR RefSeq; NP_858280.1; NC_004851.1. DR RefSeq; WP_000616104.1; NZ_WPGO01000063.1. DR RefSeq; YP_009062504.1; NC_024996.1. DR PDB; 4A5P; X-ray; 3.15 A; A/B/C=318-686. DR PDBsum; 4A5P; -. DR AlphaFoldDB; P0A1I5; -. DR SMR; P0A1I5; -. DR PaxDb; 198214-CP0147; -. DR GeneID; 1238036; -. DR KEGG; sfl:CP0147; -. DR PATRIC; fig|198214.7.peg.5394; -. DR HOGENOM; CLU_015346_3_0_6; -. DR Proteomes; UP000001006; Plasmid pCP301. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0009306; P:protein secretion; IEA:InterPro. DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1. DR Gene3D; 3.40.5.40; FHIPEP family, domain 2; 1. DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1. DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1. DR InterPro; IPR042194; FHIPEP_1. DR InterPro; IPR042193; FHIPEP_3. DR InterPro; IPR042196; FHIPEP_4. DR InterPro; IPR025505; FHIPEP_CS. DR InterPro; IPR001712; T3SS_FHIPEP. DR InterPro; IPR006302; T3SS_HrcV. DR NCBIfam; TIGR01399; hrcV; 1. DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1. DR PANTHER; PTHR30161:SF2; INVASION PROTEIN INVA; 1. DR Pfam; PF00771; FHIPEP; 1. DR PIRSF; PIRSF005419; FlhA; 1. DR PRINTS; PR00949; TYPE3IMAPROT. DR PROSITE; PS00994; FHIPEP; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell inner membrane; Cell membrane; Membrane; Plasmid; KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix; KW Transport; Virulence. FT CHAIN 1..686 FT /note="Protein MxiA" FT /id="PRO_0000190032" FT TRANSMEM 28..52 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 105..129 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 197..216 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 232..256 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 274..292 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 299..315 FT /note="Helical" FT /evidence="ECO:0000255" FT CONFLICT 95 FT /note="A -> R (in Ref. 1; AAA26529)" FT /evidence="ECO:0000305" FT CONFLICT 255..256 FT /note="IV -> ML (in Ref. 1; AAA26529)" FT /evidence="ECO:0000305" FT CONFLICT 342 FT /note="S -> T (in Ref. 1; AAA26529)" FT /evidence="ECO:0000305" FT CONFLICT 355 FT /note="A -> R (in Ref. 1; AAA26529)" FT /evidence="ECO:0000305" FT STRAND 362..368 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 377..391 FT /evidence="ECO:0007829|PDB:4A5P" FT STRAND 400..406 FT /evidence="ECO:0007829|PDB:4A5P" FT STRAND 411..416 FT /evidence="ECO:0007829|PDB:4A5P" FT STRAND 419..425 FT /evidence="ECO:0007829|PDB:4A5P" FT STRAND 431..433 FT /evidence="ECO:0007829|PDB:4A5P" FT TURN 442..444 FT /evidence="ECO:0007829|PDB:4A5P" FT STRAND 448..452 FT /evidence="ECO:0007829|PDB:4A5P" FT STRAND 455..459 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 478..491 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 494..496 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 500..511 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 515..518 FT /evidence="ECO:0007829|PDB:4A5P" FT TURN 522..524 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 527..538 FT /evidence="ECO:0007829|PDB:4A5P" FT TURN 539..541 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 547..557 FT /evidence="ECO:0007829|PDB:4A5P" FT TURN 558..560 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 564..574 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 576..583 FT /evidence="ECO:0007829|PDB:4A5P" FT STRAND 591..594 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 596..603 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 623..637 FT /evidence="ECO:0007829|PDB:4A5P" FT STRAND 644..647 FT /evidence="ECO:0007829|PDB:4A5P" FT TURN 649..651 FT /evidence="ECO:0007829|PDB:4A5P" FT HELIX 652..655 FT /evidence="ECO:0007829|PDB:4A5P" FT TURN 658..662 FT /evidence="ECO:0007829|PDB:4A5P" FT STRAND 668..670 FT /evidence="ECO:0007829|PDB:4A5P" FT STRAND 684..686 FT /evidence="ECO:0007829|PDB:4A5P" SQ SEQUENCE 686 AA; 76145 MW; BD675C2C3BED820F CRC64; MIQSFLKQVS TKPELIILVL MVMIIAMLII PLPTYLVDFL IGLNIVLAIL VFMGSFYIER ILSFSTFPSV LLITTLFRLA LSISTSRLIL VDADAGKIIT TFGQFVIGDS LAVGFVIFSI VTVVQFIVIT KGSERVAEVA ARFSLDGMPG KQMSIDADLK AGIIDAAGAK ERRSILERES QLYGSFDGAM KFIKGDAIAG IIIIFVNLIG GISVGMSQHG MSLSGALSTY TILTIGDGLV SQIPALLISI SAGFIVTRVN GDSDNMGRNI MSQIFGNPFV LIVTSALALA IGMLPGFPFF VFFLIAVTLT ALFYYKKVVE KEKSLSESDS SGYTGTFDID NSHDSSLAMI ENLDAISSET VPLILLFAEN KINANDMEGL IERIRSQFFI DYGVRLPTIL YRTSNELKVD DIVLLINEVR ADSFNIYFDK VCITDENGDI DALGIPVVST SYNERVISWV DVSYTENLTN IDAKIKSAQD EFYHQLSQAL LNNINEIFGI QETKNMLDQF ENRYPDLLKE VFRHVTIQRI SEVLQRLLGE NISVRNLKLI MESLALWAPR EKDVITLVEH VRASLSRYIC SKIAVSGEIK VVMLSGYIED AIRKGIRQTS GGSFLNMDIE VSDEVMETLA HALRELRNAK KNFVLLVSVD IRRFVKRLID NRFKSILVIS YAEIDEAYTI NVLKTI //