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Protein

Protein MxiA

Gene

mxiA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for the secretion of IPA invasins.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MxiA
Alternative name(s):
Protein VirH
Gene namesi
Name:mxiA
Synonyms:virH
Ordered Locus Names:CP0147
Encoded oniPlasmid pWR1004 Publications
Plasmid pMYSH60002 Publications
Plasmid pCP3011 Publication
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000001006 Componenti: Plasmid pCP301

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 52HelicalSequence analysisAdd BLAST25
Transmembranei105 – 129HelicalSequence analysisAdd BLAST25
Transmembranei197 – 216HelicalSequence analysisAdd BLAST20
Transmembranei232 – 256HelicalSequence analysisAdd BLAST25
Transmembranei274 – 292HelicalSequence analysisAdd BLAST19
Transmembranei299 – 315HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900321 – 686Protein MxiAAdd BLAST686

Proteomic databases

PaxDbiP0A1I5.
PRIDEiP0A1I5.

Interactioni

Protein-protein interaction databases

STRINGi198214.CP0147.

Structurei

Secondary structure

1686
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi362 – 368Combined sources7
Helixi377 – 391Combined sources15
Beta strandi400 – 407Combined sources8
Beta strandi409 – 416Combined sources8
Beta strandi419 – 425Combined sources7
Beta strandi430 – 433Combined sources4
Turni442 – 444Combined sources3
Beta strandi448 – 452Combined sources5
Beta strandi455 – 461Combined sources7
Helixi478 – 491Combined sources14
Helixi494 – 496Combined sources3
Helixi500 – 511Combined sources12
Helixi515 – 522Combined sources8
Helixi527 – 538Combined sources12
Turni539 – 541Combined sources3
Helixi547 – 557Combined sources11
Turni558 – 560Combined sources3
Helixi564 – 574Combined sources11
Helixi576 – 583Combined sources8
Beta strandi588 – 594Combined sources7
Helixi596 – 604Combined sources9
Helixi623 – 637Combined sources15
Beta strandi638 – 640Combined sources3
Beta strandi644 – 647Combined sources4
Turni649 – 651Combined sources3
Helixi652 – 660Combined sources9
Beta strandi664 – 666Combined sources3
Beta strandi668 – 670Combined sources3
Beta strandi679 – 686Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A5PX-ray3.15A/B/C318-686[»]
SMRiP0A1I5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108HR8. Bacteria.
COG4789. LUCA.
HOGENOMiHOG000254015.
KOiK03230.
OMAiHAHAGEG.

Family and domain databases

InterProiIPR025505. FHIPEP_CS.
IPR001712. T3SS_FHIPEP.
IPR006302. T3SS_HrcV.
[Graphical view]
PfamiPF00771. FHIPEP. 1 hit.
[Graphical view]
PIRSFiPIRSF005419. FlhA. 1 hit.
PRINTSiPR00949. TYPE3IMAPROT.
TIGRFAMsiTIGR01399. hrcV. 1 hit.
PROSITEiPS00994. FHIPEP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A1I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQSFLKQVS TKPELIILVL MVMIIAMLII PLPTYLVDFL IGLNIVLAIL
60 70 80 90 100
VFMGSFYIER ILSFSTFPSV LLITTLFRLA LSISTSRLIL VDADAGKIIT
110 120 130 140 150
TFGQFVIGDS LAVGFVIFSI VTVVQFIVIT KGSERVAEVA ARFSLDGMPG
160 170 180 190 200
KQMSIDADLK AGIIDAAGAK ERRSILERES QLYGSFDGAM KFIKGDAIAG
210 220 230 240 250
IIIIFVNLIG GISVGMSQHG MSLSGALSTY TILTIGDGLV SQIPALLISI
260 270 280 290 300
SAGFIVTRVN GDSDNMGRNI MSQIFGNPFV LIVTSALALA IGMLPGFPFF
310 320 330 340 350
VFFLIAVTLT ALFYYKKVVE KEKSLSESDS SGYTGTFDID NSHDSSLAMI
360 370 380 390 400
ENLDAISSET VPLILLFAEN KINANDMEGL IERIRSQFFI DYGVRLPTIL
410 420 430 440 450
YRTSNELKVD DIVLLINEVR ADSFNIYFDK VCITDENGDI DALGIPVVST
460 470 480 490 500
SYNERVISWV DVSYTENLTN IDAKIKSAQD EFYHQLSQAL LNNINEIFGI
510 520 530 540 550
QETKNMLDQF ENRYPDLLKE VFRHVTIQRI SEVLQRLLGE NISVRNLKLI
560 570 580 590 600
MESLALWAPR EKDVITLVEH VRASLSRYIC SKIAVSGEIK VVMLSGYIED
610 620 630 640 650
AIRKGIRQTS GGSFLNMDIE VSDEVMETLA HALRELRNAK KNFVLLVSVD
660 670 680
IRRFVKRLID NRFKSILVIS YAEIDEAYTI NVLKTI
Length:686
Mass (Da):76,145
Last modified:March 1, 2005 - v1
Checksum:iBD675C2C3BED820F
GO

Sequence cautioni

The sequence AAA26529 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95A → R in AAA26529 (PubMed:1639496).Curated1
Sequence conflicti255 – 256IV → ML in AAA26529 (PubMed:1639496).Curated2
Sequence conflicti342S → T in AAA26529 (PubMed:1639496).Curated1
Sequence conflicti355A → R in AAA26529 (PubMed:1639496).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91664 Genomic DNA. Translation: AAA26529.1. Different initiation.
D10999 Genomic DNA. Translation: BAA01771.1.
AL391753 Genomic DNA. Translation: CAC05822.1.
AF348706 Genomic DNA. Translation: AAK18466.1.
AF386526 Genomic DNA. Translation: AAL72333.1.
M81458 Genomic DNA. No translation available.
PIRiA44797.
RefSeqiNP_085310.1. NC_002698.1.
NP_858280.1. NC_004851.1.
YP_009062504.1. NC_024996.1.

Genome annotation databases

EnsemblBacteriaiAAL72333; AAL72333; SF_p0147.
GeneIDi1238036.
876517.
KEGGisfl:CP0147.
PATRICi18722607. VBIShiFle86970_5394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91664 Genomic DNA. Translation: AAA26529.1. Different initiation.
D10999 Genomic DNA. Translation: BAA01771.1.
AL391753 Genomic DNA. Translation: CAC05822.1.
AF348706 Genomic DNA. Translation: AAK18466.1.
AF386526 Genomic DNA. Translation: AAL72333.1.
M81458 Genomic DNA. No translation available.
PIRiA44797.
RefSeqiNP_085310.1. NC_002698.1.
NP_858280.1. NC_004851.1.
YP_009062504.1. NC_024996.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A5PX-ray3.15A/B/C318-686[»]
SMRiP0A1I5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.CP0147.

Proteomic databases

PaxDbiP0A1I5.
PRIDEiP0A1I5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL72333; AAL72333; SF_p0147.
GeneIDi1238036.
876517.
KEGGisfl:CP0147.
PATRICi18722607. VBIShiFle86970_5394.

Phylogenomic databases

eggNOGiENOG4108HR8. Bacteria.
COG4789. LUCA.
HOGENOMiHOG000254015.
KOiK03230.
OMAiHAHAGEG.

Family and domain databases

InterProiIPR025505. FHIPEP_CS.
IPR001712. T3SS_FHIPEP.
IPR006302. T3SS_HrcV.
[Graphical view]
PfamiPF00771. FHIPEP. 1 hit.
[Graphical view]
PIRSFiPIRSF005419. FlhA. 1 hit.
PRINTSiPR00949. TYPE3IMAPROT.
TIGRFAMsiTIGR01399. hrcV. 1 hit.
PROSITEiPS00994. FHIPEP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMXIA_SHIFL
AccessioniPrimary (citable) accession number: P0A1I5
Secondary accession number(s): P35533, Q55295
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.