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Protein

Protein MxiA

Gene

mxiA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for the secretion of IPA invasins.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MxiA
Alternative name(s):
Protein VirH
Gene namesi
Name:mxiA
Synonyms:virH
Ordered Locus Names:CP0147
Encoded oniPlasmid pWR1004 Publications
Plasmid pMYSH60002 Publications
Plasmid pCP3011 Publication
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000001006 Componenti: Plasmid pCP301

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 52HelicalSequence analysisAdd BLAST25
Transmembranei105 – 129HelicalSequence analysisAdd BLAST25
Transmembranei197 – 216HelicalSequence analysisAdd BLAST20
Transmembranei232 – 256HelicalSequence analysisAdd BLAST25
Transmembranei274 – 292HelicalSequence analysisAdd BLAST19
Transmembranei299 – 315HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900321 – 686Protein MxiAAdd BLAST686

Proteomic databases

PRIDEiP0A1I5

Structurei

Secondary structure

1686
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi362 – 368Combined sources7
Helixi377 – 391Combined sources15
Beta strandi400 – 406Combined sources7
Beta strandi411 – 416Combined sources6
Beta strandi419 – 425Combined sources7
Beta strandi431 – 433Combined sources3
Turni442 – 444Combined sources3
Beta strandi448 – 452Combined sources5
Beta strandi455 – 459Combined sources5
Helixi478 – 491Combined sources14
Helixi494 – 496Combined sources3
Helixi500 – 511Combined sources12
Helixi515 – 518Combined sources4
Turni522 – 524Combined sources3
Helixi527 – 538Combined sources12
Turni539 – 541Combined sources3
Helixi547 – 557Combined sources11
Turni558 – 560Combined sources3
Helixi564 – 574Combined sources11
Helixi576 – 583Combined sources8
Beta strandi591 – 594Combined sources4
Helixi596 – 603Combined sources8
Helixi623 – 637Combined sources15
Beta strandi644 – 647Combined sources4
Turni649 – 651Combined sources3
Helixi652 – 655Combined sources4
Turni658 – 662Combined sources5
Beta strandi668 – 670Combined sources3
Beta strandi684 – 686Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A5PX-ray3.15A/B/C318-686[»]
SMRiP0A1I5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108HR8 Bacteria
COG4789 LUCA
HOGENOMiHOG000254015
KOiK03230
OMAiYNERVIS

Family and domain databases

InterProiView protein in InterPro
IPR025505 FHIPEP_CS
IPR001712 T3SS_FHIPEP
IPR006302 T3SS_HrcV
PANTHERiPTHR30161 PTHR30161, 1 hit
PfamiView protein in Pfam
PF00771 FHIPEP, 1 hit
PIRSFiPIRSF005419 FlhA, 1 hit
PRINTSiPR00949 TYPE3IMAPROT
TIGRFAMsiTIGR01399 hrcV, 1 hit
PROSITEiView protein in PROSITE
PS00994 FHIPEP, 1 hit

Sequencei

Sequence statusi: Complete.

P0A1I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQSFLKQVS TKPELIILVL MVMIIAMLII PLPTYLVDFL IGLNIVLAIL
60 70 80 90 100
VFMGSFYIER ILSFSTFPSV LLITTLFRLA LSISTSRLIL VDADAGKIIT
110 120 130 140 150
TFGQFVIGDS LAVGFVIFSI VTVVQFIVIT KGSERVAEVA ARFSLDGMPG
160 170 180 190 200
KQMSIDADLK AGIIDAAGAK ERRSILERES QLYGSFDGAM KFIKGDAIAG
210 220 230 240 250
IIIIFVNLIG GISVGMSQHG MSLSGALSTY TILTIGDGLV SQIPALLISI
260 270 280 290 300
SAGFIVTRVN GDSDNMGRNI MSQIFGNPFV LIVTSALALA IGMLPGFPFF
310 320 330 340 350
VFFLIAVTLT ALFYYKKVVE KEKSLSESDS SGYTGTFDID NSHDSSLAMI
360 370 380 390 400
ENLDAISSET VPLILLFAEN KINANDMEGL IERIRSQFFI DYGVRLPTIL
410 420 430 440 450
YRTSNELKVD DIVLLINEVR ADSFNIYFDK VCITDENGDI DALGIPVVST
460 470 480 490 500
SYNERVISWV DVSYTENLTN IDAKIKSAQD EFYHQLSQAL LNNINEIFGI
510 520 530 540 550
QETKNMLDQF ENRYPDLLKE VFRHVTIQRI SEVLQRLLGE NISVRNLKLI
560 570 580 590 600
MESLALWAPR EKDVITLVEH VRASLSRYIC SKIAVSGEIK VVMLSGYIED
610 620 630 640 650
AIRKGIRQTS GGSFLNMDIE VSDEVMETLA HALRELRNAK KNFVLLVSVD
660 670 680
IRRFVKRLID NRFKSILVIS YAEIDEAYTI NVLKTI
Length:686
Mass (Da):76,145
Last modified:March 1, 2005 - v1
Checksum:iBD675C2C3BED820F
GO

Sequence cautioni

The sequence AAA26529 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95A → R in AAA26529 (PubMed:1639496).Curated1
Sequence conflicti255 – 256IV → ML in AAA26529 (PubMed:1639496).Curated2
Sequence conflicti342S → T in AAA26529 (PubMed:1639496).Curated1
Sequence conflicti355A → R in AAA26529 (PubMed:1639496).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91664 Genomic DNA Translation: AAA26529.1 Different initiation.
D10999 Genomic DNA Translation: BAA01771.1
AL391753 Genomic DNA Translation: CAC05822.1
AF348706 Genomic DNA Translation: AAK18466.1
AF386526 Genomic DNA Translation: AAL72333.1
M81458 Genomic DNA No translation available.
PIRiA44797
RefSeqiNP_085310.1, NC_002698.1
NP_858280.1, NC_004851.1
WP_000616104.1, NZ_MTPK01000040.1
YP_009062504.1, NC_024996.1

Genome annotation databases

EnsemblBacteriaiAAL72333; AAL72333; SF_p0147
GeneIDi1238036
876517
KEGGisfl:CP0147
PATRICifig|198214.7.peg.5394

Similar proteinsi

Entry informationi

Entry nameiMXIA_SHIFL
AccessioniPrimary (citable) accession number: P0A1I5
Secondary accession number(s): P35533, Q55295
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

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