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P0A1F6

- UDP_SALTY

UniProt

P0A1F6 - UDP_SALTY

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Protein

Uridine phosphorylase

Gene

udp

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).By similarity

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. uridine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. nucleotide catabolic process Source: InterPro
  2. UMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3997-MONOMER.
UniPathwayiUPA00574; UER00633.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylase (EC:2.4.2.3)
Short name:
UPase
Short name:
UrdPase
Gene namesi
Name:udp
Ordered Locus Names:STM3968
ORF Names:STMD1.21
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 253252Uridine phosphorylasePRO_0000063185Add
BLAST

Proteomic databases

PaxDbiP0A1F6.
PRIDEiP0A1F6.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi99287.STM3968.

Structurei

Secondary structure

1
253
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni7 – 93
Helixi13 – 164
Beta strandi21 – 266
Helixi28 – 303
Helixi31 – 355
Beta strandi38 – 4710
Beta strandi50 – 578
Beta strandi60 – 656
Helixi71 – 8313
Beta strandi88 – 958
Beta strandi107 – 11812
Helixi119 – 1224
Beta strandi126 – 1283
Helixi134 – 14613
Beta strandi151 – 16010
Helixi164 – 1663
Beta strandi171 – 1733
Helixi178 – 1803
Helixi183 – 1897
Beta strandi194 – 1985
Helixi199 – 2079
Turni208 – 2103
Beta strandi212 – 2198
Turni223 – 2253
Turni231 – 2333
Turni235 – 2395
Helixi240 – 25213

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RYZX-ray2.90A/B/C/D/E/F1-253[»]
1SJ9X-ray2.50A/B/C/D/E/F1-253[»]
1Y1QX-ray2.35A/B/C/D/E/F1-253[»]
1Y1RX-ray2.11A/B/C/D/E/F1-253[»]
1Y1SX-ray2.55A/B/C/D/E/F1-253[»]
1Y1TX-ray1.77A/F1-253[»]
1ZL2X-ray1.85A/B/C/D/E/F1-253[»]
2HN9X-ray2.12A/B/C/D/E/F1-253[»]
2HRDX-ray1.70A/B/C/D/E/F1-253[»]
2HSWX-ray1.99A/B1-253[»]
2HWUX-ray2.91A/B/C/D/E/F1-253[»]
2I8AX-ray1.64A/B/C/D/E/F2-253[»]
2IQ5X-ray1.90A/B2-253[»]
2OECX-ray2.19A/B/C/D/E/F2-253[»]
2OXFX-ray1.76A/F4-253[»]
2PGAX-ray1.74A/B/C/D/E/F1-253[»]
2QDKX-ray1.62A/B/C/D/E/F2-253[»]
2RJ3X-ray2.51A/B/C/D/E/F2-253[»]
3C74X-ray2.38A/B/C/D/E/F2-253[»]
3DDOX-ray1.50A/B/C/D/E/F1-253[»]
3DPSX-ray1.80A/F1-253[»]
3FWPX-ray1.86A/B/C/D/E/F1-253[»]
4E1VX-ray2.15A/B/C/D/E/F/G/H/I1-253[»]
ProteinModelPortaliP0A1F6.
SMRiP0A1F6. Positions 1-253.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A1F6.

Family & Domainsi

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.Curated

Phylogenomic databases

eggNOGiCOG2820.
HOGENOMiHOG000274897.
KOiK00757.
OMAiNVMNFEM.
OrthoDBiEOG676Z3T.
PhylomeDBiP0A1F6.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010058. Uridine_phosphorylase.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01718. Uridine-psphlse. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A1F6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKSDVFHLG LTKNDLQGAQ LAIVPGDPER VEKIAALMDK PVKLASHREF
60 70 80 90 100
TSWRAELDGK AVIVCSTGIG GPSTSIAVEE LAQLGIRTFL RIGTTGAIQP
110 120 130 140 150
HINVGDVLVT TASVRLDGAS LHFAPMEFPA VADFACTTAL VEAAKSIGAT
160 170 180 190 200
THVGVTASSD TFYPGQERYD TYSGRVVRRF KGSMEEWQAM GVMNYEMESA
210 220 230 240 250
TLLTMCASQG LRAGMVAGVI VNRTQQEIPN AETMKQTESH AVKIVVEAAR

RLL
Length:253
Mass (Da):27,139
Last modified:January 23, 2007 - v2
Checksum:i63F26AFB8427BED2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001A → R in CAA73795. (PubMed:9661793)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14282 Genomic DNA. Translation: CAA74658.2.
Y13360 Genomic DNA. Translation: CAA73795.1.
AF233324 Genomic DNA. Translation: AAF33424.1.
AE006468 Genomic DNA. Translation: AAL22812.1.
RefSeqiNP_462853.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22812; AAL22812; STM3968.
GeneIDi1255494.
KEGGistm:STM3968.
PATRICi32386803. VBISalEnt20916_4187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14282 Genomic DNA. Translation: CAA74658.2 .
Y13360 Genomic DNA. Translation: CAA73795.1 .
AF233324 Genomic DNA. Translation: AAF33424.1 .
AE006468 Genomic DNA. Translation: AAL22812.1 .
RefSeqi NP_462853.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1RYZ X-ray 2.90 A/B/C/D/E/F 1-253 [» ]
1SJ9 X-ray 2.50 A/B/C/D/E/F 1-253 [» ]
1Y1Q X-ray 2.35 A/B/C/D/E/F 1-253 [» ]
1Y1R X-ray 2.11 A/B/C/D/E/F 1-253 [» ]
1Y1S X-ray 2.55 A/B/C/D/E/F 1-253 [» ]
1Y1T X-ray 1.77 A/F 1-253 [» ]
1ZL2 X-ray 1.85 A/B/C/D/E/F 1-253 [» ]
2HN9 X-ray 2.12 A/B/C/D/E/F 1-253 [» ]
2HRD X-ray 1.70 A/B/C/D/E/F 1-253 [» ]
2HSW X-ray 1.99 A/B 1-253 [» ]
2HWU X-ray 2.91 A/B/C/D/E/F 1-253 [» ]
2I8A X-ray 1.64 A/B/C/D/E/F 2-253 [» ]
2IQ5 X-ray 1.90 A/B 2-253 [» ]
2OEC X-ray 2.19 A/B/C/D/E/F 2-253 [» ]
2OXF X-ray 1.76 A/F 4-253 [» ]
2PGA X-ray 1.74 A/B/C/D/E/F 1-253 [» ]
2QDK X-ray 1.62 A/B/C/D/E/F 2-253 [» ]
2RJ3 X-ray 2.51 A/B/C/D/E/F 2-253 [» ]
3C74 X-ray 2.38 A/B/C/D/E/F 2-253 [» ]
3DDO X-ray 1.50 A/B/C/D/E/F 1-253 [» ]
3DPS X-ray 1.80 A/F 1-253 [» ]
3FWP X-ray 1.86 A/B/C/D/E/F 1-253 [» ]
4E1V X-ray 2.15 A/B/C/D/E/F/G/H/I 1-253 [» ]
ProteinModelPortali P0A1F6.
SMRi P0A1F6. Positions 1-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM3968.

Proteomic databases

PaxDbi P0A1F6.
PRIDEi P0A1F6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL22812 ; AAL22812 ; STM3968 .
GeneIDi 1255494.
KEGGi stm:STM3968.
PATRICi 32386803. VBISalEnt20916_4187.

Phylogenomic databases

eggNOGi COG2820.
HOGENOMi HOG000274897.
KOi K00757.
OMAi NVMNFEM.
OrthoDBi EOG676Z3T.
PhylomeDBi P0A1F6.

Enzyme and pathway databases

UniPathwayi UPA00574 ; UER00633 .
BioCyci SENT99287:GCTI-3997-MONOMER.

Miscellaneous databases

EvolutionaryTracei P0A1F6.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
InterProi IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010058. Uridine_phosphorylase.
[Graphical view ]
PANTHERi PTHR21234. PTHR21234. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01718. Uridine-psphlse. 1 hit.
PROSITEi PS01232. PNP_UDP_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the gene encoding uridine phosphorylase (udp) in Salmonella typhimurium."
    Errais L.L., Ukhabotina L.S., Eremina S.Y., Evdokimova A.A., Mironov A.S.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. "Protein engineering of uridine phosphorylase from Escherichia coli K-12. I. Cloning and expression of uridine phosphorylase genes from Klebsiella aerogenes and Salmonella typhimurium in E. coli."
    Veiko V.P., Chebotaev D.V., Ovcharova I.V., Gul'Ko L.B.
    Bioorg. Khim. 24:381-387(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiUDP_SALTY
AccessioniPrimary (citable) accession number: P0A1F6
Secondary accession number(s): O08432, O33808, Q9L6M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3