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P0A1F6

- UDP_SALTY

UniProt

P0A1F6 - UDP_SALTY

Protein

Uridine phosphorylase

Gene

udp

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.By similarity

    Catalytic activityi

    Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. uridine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. nucleotide catabolic process Source: InterPro
    2. UMP salvage Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-3997-MONOMER.
    UniPathwayiUPA00574; UER00633.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uridine phosphorylase (EC:2.4.2.3)
    Short name:
    UPase
    Short name:
    UrdPase
    Gene namesi
    Name:udp
    Ordered Locus Names:STM3968
    ORF Names:STMD1.21
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 253252Uridine phosphorylasePRO_0000063185Add
    BLAST

    Proteomic databases

    PaxDbiP0A1F6.
    PRIDEiP0A1F6.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    STRINGi99287.STM3968.

    Structurei

    Secondary structure

    1
    253
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni7 – 93
    Helixi13 – 164
    Beta strandi21 – 266
    Helixi28 – 303
    Helixi31 – 355
    Beta strandi38 – 4710
    Beta strandi50 – 578
    Beta strandi60 – 656
    Helixi71 – 8313
    Beta strandi88 – 958
    Beta strandi107 – 11812
    Helixi119 – 1224
    Beta strandi126 – 1283
    Helixi134 – 14613
    Beta strandi151 – 16010
    Helixi164 – 1663
    Beta strandi171 – 1733
    Helixi178 – 1803
    Helixi183 – 1897
    Beta strandi194 – 1985
    Helixi199 – 2079
    Turni208 – 2103
    Beta strandi212 – 2198
    Turni223 – 2253
    Turni231 – 2333
    Turni235 – 2395
    Helixi240 – 25213

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1RYZX-ray2.90A/B/C/D/E/F1-253[»]
    1SJ9X-ray2.50A/B/C/D/E/F1-253[»]
    1Y1QX-ray2.35A/B/C/D/E/F1-253[»]
    1Y1RX-ray2.11A/B/C/D/E/F1-253[»]
    1Y1SX-ray2.55A/B/C/D/E/F1-253[»]
    1Y1TX-ray1.77A/F1-253[»]
    1ZL2X-ray1.85A/B/C/D/E/F1-253[»]
    2HN9X-ray2.12A/B/C/D/E/F1-253[»]
    2HRDX-ray1.70A/B/C/D/E/F1-253[»]
    2HSWX-ray1.99A/B1-253[»]
    2HWUX-ray2.91A/B/C/D/E/F1-253[»]
    2I8AX-ray1.64A/B/C/D/E/F2-253[»]
    2IQ5X-ray1.90A/B2-253[»]
    2OECX-ray2.19A/B/C/D/E/F2-253[»]
    2OXFX-ray1.76A/F4-253[»]
    2PGAX-ray1.74A/B/C/D/E/F1-253[»]
    2QDKX-ray1.62A/B/C/D/E/F2-253[»]
    2RJ3X-ray2.51A/B/C/D/E/F2-253[»]
    3C74X-ray2.38A/B/C/D/E/F2-253[»]
    3DDOX-ray1.50A/B/C/D/E/F1-253[»]
    3DPSX-ray1.80A/F1-253[»]
    3FWPX-ray1.86A/B/C/D/E/F1-253[»]
    4E1VX-ray2.15A/B/C/D/E/F/G/H/I1-253[»]
    ProteinModelPortaliP0A1F6.
    SMRiP0A1F6. Positions 1-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0A1F6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PNP/UDP phosphorylase family.Curated

    Phylogenomic databases

    eggNOGiCOG2820.
    HOGENOMiHOG000274897.
    KOiK00757.
    OMAiNVMNFEM.
    OrthoDBiEOG676Z3T.
    PhylomeDBiP0A1F6.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    InterProiIPR018017. Nucleoside_phosphorylase.
    IPR018016. Nucleoside_phosphorylase_CS.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR010058. Uridine_phosphorylase.
    [Graphical view]
    PANTHERiPTHR21234. PTHR21234. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01718. Uridine-psphlse. 1 hit.
    PROSITEiPS01232. PNP_UDP_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0A1F6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKSDVFHLG LTKNDLQGAQ LAIVPGDPER VEKIAALMDK PVKLASHREF    50
    TSWRAELDGK AVIVCSTGIG GPSTSIAVEE LAQLGIRTFL RIGTTGAIQP 100
    HINVGDVLVT TASVRLDGAS LHFAPMEFPA VADFACTTAL VEAAKSIGAT 150
    THVGVTASSD TFYPGQERYD TYSGRVVRRF KGSMEEWQAM GVMNYEMESA 200
    TLLTMCASQG LRAGMVAGVI VNRTQQEIPN AETMKQTESH AVKIVVEAAR 250
    RLL 253
    Length:253
    Mass (Da):27,139
    Last modified:January 23, 2007 - v2
    Checksum:i63F26AFB8427BED2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti200 – 2001A → R in CAA73795. (PubMed:9661793)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14282 Genomic DNA. Translation: CAA74658.2.
    Y13360 Genomic DNA. Translation: CAA73795.1.
    AF233324 Genomic DNA. Translation: AAF33424.1.
    AE006468 Genomic DNA. Translation: AAL22812.1.
    RefSeqiNP_462853.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL22812; AAL22812; STM3968.
    GeneIDi1255494.
    KEGGistm:STM3968.
    PATRICi32386803. VBISalEnt20916_4187.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14282 Genomic DNA. Translation: CAA74658.2 .
    Y13360 Genomic DNA. Translation: CAA73795.1 .
    AF233324 Genomic DNA. Translation: AAF33424.1 .
    AE006468 Genomic DNA. Translation: AAL22812.1 .
    RefSeqi NP_462853.1. NC_003197.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1RYZ X-ray 2.90 A/B/C/D/E/F 1-253 [» ]
    1SJ9 X-ray 2.50 A/B/C/D/E/F 1-253 [» ]
    1Y1Q X-ray 2.35 A/B/C/D/E/F 1-253 [» ]
    1Y1R X-ray 2.11 A/B/C/D/E/F 1-253 [» ]
    1Y1S X-ray 2.55 A/B/C/D/E/F 1-253 [» ]
    1Y1T X-ray 1.77 A/F 1-253 [» ]
    1ZL2 X-ray 1.85 A/B/C/D/E/F 1-253 [» ]
    2HN9 X-ray 2.12 A/B/C/D/E/F 1-253 [» ]
    2HRD X-ray 1.70 A/B/C/D/E/F 1-253 [» ]
    2HSW X-ray 1.99 A/B 1-253 [» ]
    2HWU X-ray 2.91 A/B/C/D/E/F 1-253 [» ]
    2I8A X-ray 1.64 A/B/C/D/E/F 2-253 [» ]
    2IQ5 X-ray 1.90 A/B 2-253 [» ]
    2OEC X-ray 2.19 A/B/C/D/E/F 2-253 [» ]
    2OXF X-ray 1.76 A/F 4-253 [» ]
    2PGA X-ray 1.74 A/B/C/D/E/F 1-253 [» ]
    2QDK X-ray 1.62 A/B/C/D/E/F 2-253 [» ]
    2RJ3 X-ray 2.51 A/B/C/D/E/F 2-253 [» ]
    3C74 X-ray 2.38 A/B/C/D/E/F 2-253 [» ]
    3DDO X-ray 1.50 A/B/C/D/E/F 1-253 [» ]
    3DPS X-ray 1.80 A/F 1-253 [» ]
    3FWP X-ray 1.86 A/B/C/D/E/F 1-253 [» ]
    4E1V X-ray 2.15 A/B/C/D/E/F/G/H/I 1-253 [» ]
    ProteinModelPortali P0A1F6.
    SMRi P0A1F6. Positions 1-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM3968.

    Proteomic databases

    PaxDbi P0A1F6.
    PRIDEi P0A1F6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL22812 ; AAL22812 ; STM3968 .
    GeneIDi 1255494.
    KEGGi stm:STM3968.
    PATRICi 32386803. VBISalEnt20916_4187.

    Phylogenomic databases

    eggNOGi COG2820.
    HOGENOMi HOG000274897.
    KOi K00757.
    OMAi NVMNFEM.
    OrthoDBi EOG676Z3T.
    PhylomeDBi P0A1F6.

    Enzyme and pathway databases

    UniPathwayi UPA00574 ; UER00633 .
    BioCyci SENT99287:GCTI-3997-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P0A1F6.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    InterProi IPR018017. Nucleoside_phosphorylase.
    IPR018016. Nucleoside_phosphorylase_CS.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR010058. Uridine_phosphorylase.
    [Graphical view ]
    PANTHERi PTHR21234. PTHR21234. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01718. Uridine-psphlse. 1 hit.
    PROSITEi PS01232. PNP_UDP_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the gene encoding uridine phosphorylase (udp) in Salmonella typhimurium."
      Errais L.L., Ukhabotina L.S., Eremina S.Y., Evdokimova A.A., Mironov A.S.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    2. "Protein engineering of uridine phosphorylase from Escherichia coli K-12. I. Cloning and expression of uridine phosphorylase genes from Klebsiella aerogenes and Salmonella typhimurium in E. coli."
      Veiko V.P., Chebotaev D.V., Ovcharova I.V., Gul'Ko L.B.
      Bioorg. Khim. 24:381-387(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiUDP_SALTY
    AccessioniPrimary (citable) accession number: P0A1F6
    Secondary accession number(s): O08432, O33808, Q9L6M8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3