SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0A1F2

- DAPF_SALTY

UniProt

P0A1F2 - DAPF_SALTY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Diaminopimelate epimerase

Gene
dapF, STM3947, STMD1.43
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei44 – 441Substrate By similarity
Binding sitei64 – 641Substrate By similarity
Active sitei73 – 731Proton donor/acceptor By similarity
Binding sitei157 – 1571Substrate By similarity
Sitei159 – 1591Important for catalytic activity By similarity
Binding sitei190 – 1901Substrate By similarity
Sitei208 – 2081Important for catalytic activity By similarity
Active sitei217 – 2171Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3976-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:STM3947
ORF Names:STMD1.43
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Diaminopimelate epimeraseUniRule annotationPRO_0000149869Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi73 ↔ 217UniRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0A1F2.
PRIDEiP0A1F2.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM3947.

Structurei

3D structure databases

ProteinModelPortaliP0A1F2.
SMRiP0A1F2. Positions 1-274.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 92Substrate binding By similarity
Regioni73 – 753Substrate binding By similarity
Regioni208 – 2092Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiLIVEPPY.
OrthoDBiEOG6ND0M5.
PhylomeDBiP0A1F2.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A1F2-1 [UniParc]FASTAAdd to Basket

« Hide

MQFSKMHGLG NDFMVVDAVT QNVFFSPELI RRLSDRHLGV GFDQLLVVEP    50
PYDPELDFHY RIFNADGSEV SQCGNGARCF ARFVRLKGLT NKRDIRVSTA 100
NGRMVLSVTE DELVRVNMGE PNFEPAQVPF RANKAEKTYI MRAAEQTILC 150
GVVSMGNPHC VIQVDNVDTA AVETLGPVLE SHERFPERAN IGFMQVVRRE 200
HIRLRVYERG AGETRACGSG ACAAVAVGIQ QGLLAEEVRV ELPGGRLDIA 250
WKGPGHPLYM TGPAAHIYDG FIHL 274
Length:274
Mass (Da):30,337
Last modified:March 1, 2005 - v1
Checksum:i2FBB315B7DA12AE9
GO

Sequence cautioni

The sequence AAF33445.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAL22791.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF233324 Genomic DNA. Translation: AAF33445.1. Different initiation.
AE006468 Genomic DNA. Translation: AAL22791.1. Different initiation.
RefSeqiNP_462832.2. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22791; AAL22791; STM3947.
GeneIDi1255473.
KEGGistm:STM3947.
PATRICi32386759. VBISalEnt20916_4165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF233324 Genomic DNA. Translation: AAF33445.1 . Different initiation.
AE006468 Genomic DNA. Translation: AAL22791.1 . Different initiation.
RefSeqi NP_462832.2. NC_003197.1.

3D structure databases

ProteinModelPortali P0A1F2.
SMRi P0A1F2. Positions 1-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM3947.

Proteomic databases

PaxDbi P0A1F2.
PRIDEi P0A1F2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL22791 ; AAL22791 ; STM3947 .
GeneIDi 1255473.
KEGGi stm:STM3947.
PATRICi 32386759. VBISalEnt20916_4165.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi LIVEPPY.
OrthoDBi EOG6ND0M5.
PhylomeDBi P0A1F2.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci SENT99287:GCTI-3976-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiDAPF_SALTY
AccessioniPrimary (citable) accession number: P0A1F2
Secondary accession number(s): Q9L6P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi