Reviewed,
UniProtKB/Swiss-Prot P0A1F0 (DDLA_SALTY)
Last modified
November 3, 2009.
Version 38.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: D-alanine--D-alanine ligase A EC=6.3.2.4 Alternative name(s): D-alanylalanine synthetase A D-Ala-D-Ala ligase A | ||||
| Gene names |
| ||||
| Organism | Salmonella typhimurium [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 90371 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 364 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Cell wall formation. HAMAP MF_00047 |
| Catalytic activity | ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP MF_00047 |
| Cofactor | Binds 2 magnesium or manganese ions per subunit By similarity. |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00047 |
| Subcellular location | |
| Sequence similarities | Belongs to the D-alanine--D-alanine ligase family. Contains 1 ATP-grasp domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.1 | ||||||
| Chain | 2 – 364 | 363 | D-alanine--D-alanine ligase A HAMAP MF_00047 | PRO_0000177868 | |||||
Regions | |||||||||
| Domain | 145 – 348 | 204 | ATP-grasp | ||||||
| Nucleotide binding | 175 – 230 | 56 | ATP By similarity | ||||||
Sites | |||||||||
| Metal binding | 302 | 1 | Magnesium or manganese 1 By similarity | ||||||
| Metal binding | 315 | 1 | Magnesium or manganese 1 By similarity | ||||||
| Metal binding | 315 | 1 | Magnesium or manganese 2 By similarity | ||||||
| Metal binding | 317 | 1 | Magnesium or manganese 2 By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 17 | 1 | H → A | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation, cloning, and sequencing of the Salmonella typhimurium ddlA gene with purification and characterization of its product, D-alanine:D-alanine ligase (ADP forming)." Daub E., Zawadzke L.E., Botstein D., Walsh C.T. Biochemistry 27:3701-3708(1988) [PubMed: 2841972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-36. |
| [2] | "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. Wilson R.K.Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M20793 Genomic DNA. Translation: AAA27056.1. AE006468 Genomic DNA. Translation: AAL19334.1. | |||||||||||||
| PIR | CEEBDT. A28642. | ||||||||||||
| RefSeq | NP_459375.1. | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P0A1F0. | ||||||||||||
Genome annotation databases | |||||||||||||
| GeneID | 1251899. | ||||||||||||
| GenomeReviews | Gene locus STM0380 in contig AE006468_GR. | ||||||||||||
| KEGG | stm:STM0380. | ||||||||||||
Organism-specific databases | |||||||||||||
| CMR | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P0A1F0. | ||||||||||||
| OMA | GREIECG. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BioCyc | STYP99287:STM0380-MON. | ||||||||||||
| BRENDA | 6.3.2.4. 2. | ||||||||||||
Family and domain databases | |||||||||||||
| HAMAP | MF_00047. [Tree] | ||||||||||||
| InterPro | IPR011761. ATP-grasp. IPR013816. ATP_grasp_subdomain_2. IPR000291. D-Ala_lig_Van_CS. IPR005905. D_ala_D_ala. IPR011095. Dala_Dala_lig_C. IPR011127. Dala_Dala_lig_N. IPR013817. Pre-ATP_grasp. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit. | ||||||||||||
| Pfam | PF07478. Dala_Dala_lig_C. 1 hit. PF01820. Dala_Dala_lig_N. 1 hit. [Graphical view] | ||||||||||||
| TIGRFAMs | TIGR01205. D_ala_D_alaTIGR. 1 hit. | ||||||||||||
| PROSITE | PS50975. ATP_GRASP. 1 hit. PS00843. DALA_DALA_LIGASE_1. 1 hit. PS00844. DALA_DALA_LIGASE_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | DDLA_SALTY | ||||||||
| Accession | Primary (citable) accession number: P0A1F0 Secondary accession number(s): P15051 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

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