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P0A1E4 (CYSK_SALTI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cysteine synthase A
Short name=CSase A
EC=2.5.1.47
Alternative name(s):
O-acetylserine (thiol)-lyase A
Short name=OAS-TL A
O-acetylserine sulfhydrylase A
Gene names
Name:cysK
Ordered Locus Names:STY2666, t0427
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product By similarity.

Catalytic activity

O(3)-acetyl-L-serine + H2S = L-cysteine + acetate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the cysteine synthase/cystathionine beta-synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 323322Cysteine synthase A
PRO_0000167088

Regions

Region177 – 1815Pyridoxal phosphate binding By similarity

Sites

Binding site81Allosteric inhibitor By similarity
Binding site721Pyridoxal phosphate By similarity
Binding site2691Allosteric inhibitor; via amide nitrogen By similarity
Binding site2731Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue421N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A1E4 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: CE74168FAAE99B9E

FASTA32334,536
        10         20         30         40         50         60 
MSKIYEDNSL TIGHTPLVRL NRIGNGRILA KVESRNPSFS VKCRIGANMI WDAEKRGVLK 

        70         80         90        100        110        120 
PGVELVEPTS GNTGIALAYV AAARGYKLTL TMPETMSIER RKLLKALGAN LVLTEGAKGM 

       130        140        150        160        170        180 
KGAIQKAEEI VASDPQKYLL LQQFSNPANP EIHEKTTGPE IWEDTDGQVD VFISGVGTGG 

       190        200        210        220        230        240 
TLTGVTRYIK GTKGKTDLIT VAVEPTDSPV IAQALAGEEI KPGPHKIQGI GAGFIPGNLD 

       250        260        270        280        290        300 
LKLIDKVVGI TNEEAISTAR RLMEEEGILA GISSGAAVAA ALKLQEDESF TNKNIVVILP 

       310        320 
SSGERYLSTA LFADLFTEKE LQQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL627274 Genomic DNA. Translation: CAD07662.1.
AE014613 Genomic DNA. Translation: AAO68145.1.
RefSeqNP_456967.1. NC_003198.1.
NP_804296.1. NC_004631.1.

3D structure databases

ProteinModelPortalP0A1E4.
SMRP0A1E4. Positions 2-323.
ModBaseSearch...

Proteomic databases

PRIDEP0A1E4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1068474.
1248985.
GenomeReviewsGene locus t0427 in contig AE014613_GR.
Gene locus STY2666 in contig AL513382_GR.
KEGGstt:t0427.
sty:STY2666.
PATRIC18543322. VBISalEnt120419_2702.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG748215.
OMAAHSIGNT.
ProtClustDBPRK10717.

Enzyme and pathway databases

BioCycSENT209261:T0427-MONOMER.
SENT220341:STY2666-MONOMER.

Family and domain databases

InterProIPR001216. Cys_synth_BS.
IPR005856. Cys_synthKM.
IPR005859. CysK.
IPR001926. PyrdxlP-dep_enz_bsu.
[Graphical view]
KOK01738.
PfamPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMSSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMsTIGR01139. CysK. 1 hit.
TIGR01136. CysKM. 1 hit.
PROSITEPS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYSK_SALTI
AccessionPrimary (citable) accession number: P0A1E4
Secondary accession number(s): P12674
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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