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P0A1B6 (AROF_SALTI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive
EC=2.5.1.54
Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase
Gene names
Name:aroF
Ordered Locus Names:STY2857, t2625
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

Catalytic activity

Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.

Miscellaneous

There are 3 DAHP synthases, AroF is feedback-inhibited by Tyr. The other 2 DAHP synthases are Phe- and Trp-sensitive, respectively.

Sequence similarities

Belongs to the class-I DAHP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3-deoxy-7-phosphoheptulonate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive
PRO_0000140833

Sequences

Sequence LengthMass (Da)Tools
P0A1B6 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 51EC218FC47B30A4

FASTA35638,713
        10         20         30         40         50         60 
MQKDALNNVR ITDEQVLMTP EQLKAAFPLS LAQEAQIAQS RGIISDIIAG RDPRLLVVCG 

        70         80         90        100        110        120 
PCSIHDPETA LEYARRFKAL AAEVSDSLYL VMRVYFEKPR TTVGWKGLIN DPHMDGSFDV 

       130        140        150        160        170        180 
EAGLKIARQL LVELVNMGLP LATEALDPNS PQYLGDLFSW SAIGARTTES QTHREMASGL 

       190        200        210        220        230        240 
SMPVGFKNGT DGSLATAINA MRAAAQPHRF VGINQAGQVA LLQTQGNPHG HVILRGGKAP 

       250        260        270        280        290        300 
NYSPADVAQC EKEMEQAGLR PSLMVDCSHG NSNKDYRRQP AVAESVVAQI KDGNRSIIGL 

       310        320        330        340        350 
MIESNIHEGN QSSEQPRSEM KYGVSVTDAC ISWEMTDALL REIHKDLSGQ LAVRVA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL627276 Genomic DNA. Translation: CAD05849.1.
AE014613 Genomic DNA. Translation: AAO70196.1.
RefSeqNP_457140.1. NC_003198.1.
NP_806336.1. NC_004631.1.

3D structure databases

ProteinModelPortalP0A1B6.
SMRP0A1B6. Positions 8-348.
ModBaseSearch...

Proteomic databases

PRIDEP0A1B6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1067601.
1249170.
GenomeReviewsGene locus t2625 in contig AE014613_GR.
Gene locus STY2857 in contig AL513382_GR.
KEGGstt:t2625.
sty:STY2857.
PATRIC18543740. VBISalEnt120419_2906.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG670536.
OMARGNRYGH.
ProtClustDBPRK12755.

Enzyme and pathway databases

BioCycSENT209261:T2625-MONOMER.
SENT220341:STY2857-MONOMER.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006219. DHAP_synth_1.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01626.
PANTHERPTHR21225. AroFGH. 1 hit.
PfamPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
PIRSFPIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMsTIGR00034. AroFGH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROF_SALTI
AccessionPrimary (citable) accession number: P0A1B6
Secondary accession number(s): P21307
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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