Reviewed, UniProtKB/Swiss-Prot P0A1B3 (ARGR_SALTY)

Names and origin

Protein names

Recommended name:
    Arginine repressor

Gene names

Name:	argR
Ordered Locus Names:	STM3360

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. HAMAP MF_00173
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis. [regulation] HAMAP MF_00173
Subunit structure	Homohexamer. HAMAP MF_00173
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the argR family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis Transcription Transcription regulation
Cellular component	Cytoplasm
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 156	156	Arginine repressor HAMAP MF_00173		PRO_0000205111

Sequences

	Sequence		Length	Mass (Da)
	P0A1B3-1 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 4936CEDE85F35FAC	FASTA	156	17,066
	10 20 30 40 50 60 MRSSAKQEEL VRAFKALLKE EKFSSQGEIV LALQDQGFEN INQSKVSRML TKFGAVRTRN 70 80 90 100 110 120 AKMEMVYCLP AELGVPTTSS PLKNLVLDID YNDAVVVIHT SPGAAQLIAR LLDSLGKAEG 130 140 150 ILGTIAGDDT IFTTPASGFS VRDLYEAILE LFEQEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the arginine repressor from Salmonella typhimurium and its interactions with the carAB operator." Lu C.-D., Houghton J.E., Abdelal A.T. J. Mol. Biol. 225:11-24(1992) [PubMed: 1583685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M75913 Genomic DNA. Translation: AAA27027.1. AE006468 Genomic DNA. Translation: AAL22229.1.
PIR	S21802.
RefSeq	NP_462270.1.
3D structure databases
HSSP	HSSP built from PDB template 1XXA based on UniProtKB P15282.
SMR	P0A1B3. Positions 1-78, 81-153.
ModBase	Search...
Proteomic databases
PRIDE	P0A1B3.
Genome annotation databases
GeneID	1254883.
GenomeReviews	Gene locus STM3360 in contig AE006468_GR.
KEGG	stm:STM3360.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0A1B3.
OMA	DDTIFVT.
Enzyme and pathway databases
BioCyc	STYP99287:STM3360-MON.
Family and domain databases
HAMAP	MF_00173. [Tree]
InterPro	IPR001669. Arg_repress. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.40. Arg_repress. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF01316. Arg_repressor. 1 hit. PF02863. Arg_repressor_C. 1 hit. [Graphical view]
PRINTS	PR01467. ARGREPRESSOR.
ProDom	PD007402. Arg_repress. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01529. argR_whole. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGR_SALTY

Accession

Primary (citable) accession number: P0A1B3
Secondary accession number(s): P37170

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)