Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0A1A8

- CYAA_SALTI

UniProt

P0A1A8 - CYAA_SALTI

Protein

Adenylate cyclase

Gene

cyaA

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    GO - Molecular functioni

    1. adenylate cyclase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase
    Gene namesi
    Name:cyaA
    Synonyms:cya
    Ordered Locus Names:STY3620, t3358
    OrganismiSalmonella typhi
    Taxonomic identifieri90370 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 848848Adenylate cyclasePRO_0000195672Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei609 – 6091Phosphohistidine; by CRRSequence Analysis

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi220341.STY3620.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 535535CatalyticAdd
    BLAST
    Regioni541 – 848308RegulatoryAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-1 family.Curated

    Phylogenomic databases

    eggNOGiCOG3072.
    HOGENOMiHOG000270910.
    KOiK05851.
    OMAiSEGFLQF.
    OrthoDBiEOG63JR9H.

    Family and domain databases

    InterProiIPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view]
    PfamiPF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A1A8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPLMP    50
    GYLDGNVPSG ICFYTPDETQ RHYLNELELY RGMTPQDPPK GELPITGVYT 100
    MGSTSSVGQS CSSDLDIWVC HQSWLDGEER QLLQRKCSLL ESWAASLGVE 150
    VSFFLIDENR FRHNESGSLG GEDCGSTQHI LLLDEFYRTA VRLAGKRILW 200
    SMVPCDEEEH YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA EEYFGASLWQ 250
    LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL LAKDIKQRLH DGEIVSFGLD 300
    PYCMMLERVT EYLTAIEDPT RLDLVRRCFY LKVCEKLSRE RACVGWRREV 350
    LSQLVSEWGW DDARLTMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF 400
    ARRNNLSVSA SPQDIGVLTR KLYAAFEALP GKVTLVNPQI SPDLSEPNLT 450
    FIHVPPGRAN RSGWYLYNRA PNMDSIISHQ PLEYNRYLNK LVAWAWFNGL 500
    LTSRTHLFIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP KALYSPCEIR 550
    HLAIIVNLEY DPTAAFRNKV VHFDFRKLDV FSFGEEQNCL IGSIDLLYRN 600
    SWNEVRTLHF NGEQAMIEAL KTILGKMHQD AAPPDSVEVF CYSQHLRGLI 650
    RTRVQQLVSE CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL 700
    ENAIEFYGAI SHNKLHGLSV QVETNQVKLP SVVDGFASEG IIQFFFEETG 750
    DEKGFNIYIL DESNRAEVYH HCEGSKEELV RDVSRFYSSS HDRFTYGSSF 800
    INFNLPQFYQ IVKTDGRAQV IPFRTQPINT VPPANQDHDA PLLQQYFS 848
    Length:848
    Mass (Da):97,359
    Last modified:March 1, 2005 - v1
    Checksum:iEBA1E01E1AD60641
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD09381.1.
    AE014613 Genomic DNA. Translation: AAO70886.1.
    RefSeqiNP_457812.1. NC_003198.1.
    NP_807026.1. NC_004631.1.

    Genome annotation databases

    EnsemblBacteriaiAAO70886; AAO70886; t3358.
    CAD09381; CAD09381; CAD09381.
    GeneIDi1249875.
    KEGGisty:STY3620.
    PATRICi18545350. VBISalEnt120419_3689.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD09381.1 .
    AE014613 Genomic DNA. Translation: AAO70886.1 .
    RefSeqi NP_457812.1. NC_003198.1.
    NP_807026.1. NC_004631.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220341.STY3620.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO70886 ; AAO70886 ; t3358 .
    CAD09381 ; CAD09381 ; CAD09381 .
    GeneIDi 1249875.
    KEGGi sty:STY3620.
    PATRICi 18545350. VBISalEnt120419_3689.

    Phylogenomic databases

    eggNOGi COG3072.
    HOGENOMi HOG000270910.
    KOi K05851.
    OMAi SEGFLQF.
    OrthoDBi EOG63JR9H.

    Family and domain databases

    InterProi IPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view ]
    Pfami PF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEi PS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT18.
    2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
      Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
      J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.

    Entry informationi

    Entry nameiCYAA_SALTI
    AccessioniPrimary (citable) accession number: P0A1A8
    Secondary accession number(s): Q05878
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3