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Protein

Adenylate cyclase

Gene

cyaA

Organism
Salmonella typhi
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processcAMP biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:cyaA
Synonyms:cya
Ordered Locus Names:STY3620, t3358
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001956721 – 848Adenylate cyclaseAdd BLAST848

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei609Phosphohistidine; by CRRSequence analysis1

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi220341.STY3620

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 535CatalyticAdd BLAST535
Regioni541 – 848RegulatoryAdd BLAST308

Sequence similaritiesi

Belongs to the adenylyl cyclase class-1 family.Curated

Phylogenomic databases

eggNOGiENOG4107T0K Bacteria
COG3072 LUCA
HOGENOMiHOG000270910
KOiK05851
OMAiHPLLPGY

Family and domain databases

InterProiView protein in InterPro
IPR000274 Adenylate_cyclase_1
IPR024686 Adenylate_cyclase_1_CS
IPR024685 Adenylate_cyclase_1_N
PANTHERiPTHR38760 PTHR38760, 1 hit
PfamiView protein in Pfam
PF12633 Adenyl_cycl_N, 1 hit
PF01295 Adenylate_cycl, 1 hit
PIRSFiPIRSF001444 Adenylate_cycl, 1 hit
PROSITEiView protein in PROSITE
PS01092 ADENYLATE_CYCLASE_1_1, 1 hit
PS01093 ADENYLATE_CYCLASE_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A1A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPLMP
60 70 80 90 100
GYLDGNVPSG ICFYTPDETQ RHYLNELELY RGMTPQDPPK GELPITGVYT
110 120 130 140 150
MGSTSSVGQS CSSDLDIWVC HQSWLDGEER QLLQRKCSLL ESWAASLGVE
160 170 180 190 200
VSFFLIDENR FRHNESGSLG GEDCGSTQHI LLLDEFYRTA VRLAGKRILW
210 220 230 240 250
SMVPCDEEEH YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA EEYFGASLWQ
260 270 280 290 300
LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL LAKDIKQRLH DGEIVSFGLD
310 320 330 340 350
PYCMMLERVT EYLTAIEDPT RLDLVRRCFY LKVCEKLSRE RACVGWRREV
360 370 380 390 400
LSQLVSEWGW DDARLTMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF
410 420 430 440 450
ARRNNLSVSA SPQDIGVLTR KLYAAFEALP GKVTLVNPQI SPDLSEPNLT
460 470 480 490 500
FIHVPPGRAN RSGWYLYNRA PNMDSIISHQ PLEYNRYLNK LVAWAWFNGL
510 520 530 540 550
LTSRTHLFIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP KALYSPCEIR
560 570 580 590 600
HLAIIVNLEY DPTAAFRNKV VHFDFRKLDV FSFGEEQNCL IGSIDLLYRN
610 620 630 640 650
SWNEVRTLHF NGEQAMIEAL KTILGKMHQD AAPPDSVEVF CYSQHLRGLI
660 670 680 690 700
RTRVQQLVSE CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL
710 720 730 740 750
ENAIEFYGAI SHNKLHGLSV QVETNQVKLP SVVDGFASEG IIQFFFEETG
760 770 780 790 800
DEKGFNIYIL DESNRAEVYH HCEGSKEELV RDVSRFYSSS HDRFTYGSSF
810 820 830 840
INFNLPQFYQ IVKTDGRAQV IPFRTQPINT VPPANQDHDA PLLQQYFS
Length:848
Mass (Da):97,359
Last modified:March 1, 2005 - v1
Checksum:iEBA1E01E1AD60641
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA Translation: CAD09381.1
AE014613 Genomic DNA Translation: AAO70886.1
RefSeqiNP_457812.1, NC_003198.1
WP_000281718.1, NZ_PHKG01000018.1

Genome annotation databases

EnsemblBacteriaiAAO70886; AAO70886; t3358
CAD09381; CAD09381; CAD09381
GeneIDi1249875
KEGGistt:t3358
sty:STY3620
PATRICifig|220341.7.peg.3689

Similar proteinsi

Entry informationi

Entry nameiCYAA_SALTI
AccessioniPrimary (citable) accession number: P0A1A8
Secondary accession number(s): Q05878
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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