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P0A1A8

- CYAA_SALTI

UniProt

P0A1A8 - CYAA_SALTI

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Protein

Adenylate cyclase

Gene
cyaA, cya, STY3620, t3358
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:cyaA
Synonyms:cya
Ordered Locus Names:STY3620, t3358
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 848848Adenylate cyclasePRO_0000195672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei609 – 6091Phosphohistidine; by CRR Reviewed prediction

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi220341.STY3620.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 535535CatalyticAdd
BLAST
Regioni541 – 848308RegulatoryAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3072.
HOGENOMiHOG000270910.
KOiK05851.
OMAiSEGFLQF.
OrthoDBiEOG63JR9H.

Family and domain databases

InterProiIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamiPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A1A8-1 [UniParc]FASTAAdd to Basket

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MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPLMP    50
GYLDGNVPSG ICFYTPDETQ RHYLNELELY RGMTPQDPPK GELPITGVYT 100
MGSTSSVGQS CSSDLDIWVC HQSWLDGEER QLLQRKCSLL ESWAASLGVE 150
VSFFLIDENR FRHNESGSLG GEDCGSTQHI LLLDEFYRTA VRLAGKRILW 200
SMVPCDEEEH YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA EEYFGASLWQ 250
LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL LAKDIKQRLH DGEIVSFGLD 300
PYCMMLERVT EYLTAIEDPT RLDLVRRCFY LKVCEKLSRE RACVGWRREV 350
LSQLVSEWGW DDARLTMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF 400
ARRNNLSVSA SPQDIGVLTR KLYAAFEALP GKVTLVNPQI SPDLSEPNLT 450
FIHVPPGRAN RSGWYLYNRA PNMDSIISHQ PLEYNRYLNK LVAWAWFNGL 500
LTSRTHLFIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP KALYSPCEIR 550
HLAIIVNLEY DPTAAFRNKV VHFDFRKLDV FSFGEEQNCL IGSIDLLYRN 600
SWNEVRTLHF NGEQAMIEAL KTILGKMHQD AAPPDSVEVF CYSQHLRGLI 650
RTRVQQLVSE CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL 700
ENAIEFYGAI SHNKLHGLSV QVETNQVKLP SVVDGFASEG IIQFFFEETG 750
DEKGFNIYIL DESNRAEVYH HCEGSKEELV RDVSRFYSSS HDRFTYGSSF 800
INFNLPQFYQ IVKTDGRAQV IPFRTQPINT VPPANQDHDA PLLQQYFS 848
Length:848
Mass (Da):97,359
Last modified:March 1, 2005 - v1
Checksum:iEBA1E01E1AD60641
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD09381.1.
AE014613 Genomic DNA. Translation: AAO70886.1.
RefSeqiNP_457812.1. NC_003198.1.
NP_807026.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO70886; AAO70886; t3358.
CAD09381; CAD09381; CAD09381.
GeneIDi1249875.
KEGGisty:STY3620.
PATRICi18545350. VBISalEnt120419_3689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD09381.1 .
AE014613 Genomic DNA. Translation: AAO70886.1 .
RefSeqi NP_457812.1. NC_003198.1.
NP_807026.1. NC_004631.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY3620.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO70886 ; AAO70886 ; t3358 .
CAD09381 ; CAD09381 ; CAD09381 .
GeneIDi 1249875.
KEGGi sty:STY3620.
PATRICi 18545350. VBISalEnt120419_3689.

Phylogenomic databases

eggNOGi COG3072.
HOGENOMi HOG000270910.
KOi K05851.
OMAi SEGFLQF.
OrthoDBi EOG63JR9H.

Family and domain databases

InterProi IPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view ]
Pfami PF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view ]
PIRSFi PIRSF001444. Adenylate_cycl. 1 hit.
PROSITEi PS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiCYAA_SALTI
AccessioniPrimary (citable) accession number: P0A1A8
Secondary accession number(s): Q05878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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