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P0A1A7

- CYAA_SALTY

UniProt

P0A1A7 - CYAA_SALTY

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Protein
Adenylate cyclase
Gene
cyaA, cya, STM3939, STMD1.50
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Enzyme regulationi

The regulatory domain is involved in the regulation of cyclase activity by the carbon source. Activated by the PTS system, glucose-specific IIA component (CRR).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. adenylate cyclase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-3968-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase
    Gene namesi
    Name:cyaA
    Synonyms:cya
    Ordered Locus Names:STM3939
    ORF Names:STMD1.50
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 848848Adenylate cyclase
    PRO_0000195673Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei609 – 6091Phosphohistidine; by CRR Reviewed prediction

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM3939.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 535535Catalytic
    Add
    BLAST
    Regioni541 – 848308Regulatory
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3072.
    HOGENOMiHOG000270910.
    KOiK05851.
    OMAiSEGFLQF.
    OrthoDBiEOG63JR9H.
    PhylomeDBiP0A1A7.

    Family and domain databases

    InterProiIPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view]
    PfamiPF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEiPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A1A7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPLMP    50
    GYLDGNVPSG ICFYTPDETQ RHYLNELELY RGMTPQDPPK GELPITGVYT 100
    MGSTSSVGQS CSSDLDIWVC HQSWLDGEER QLLQRKCSLL ESWAASLGVE 150
    VSFFLIDENR FRHNESGSLG GEDCGSTQHI LLLDEFYRTA VRLAGKRILW 200
    SMVPCDEEEH YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA EEYFGASLWQ 250
    LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL LAKDIKQRLH DGEIVSFGLD 300
    PYCMMLERVT EYLTAIEDPT RLDLVRRCFY LKVCEKLSRE RACVGWRREV 350
    LSQLVSEWGW DDARLTMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF 400
    ARRNNLSVSA SPQDIGVLTR KLYAAFEALP GKVTLVNPQI SPDLSEPNLT 450
    FIHVPPGRAN RSGWYLYNRA PNMDSIISHQ PLEYNRYLNK LVAWAWFNGL 500
    LTSRTHLFIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP KALYSPCEIR 550
    HLAIIVNLEY DPTAAFRNKV VHFDFRKLDV FSFGEEQNCL IGSIDLLYRN 600
    SWNEVRTLHF NGEQAMIEAL KTILGKMHQD AAPPDSVEVF CYSQHLRGLI 650
    RTRVQQLVSE CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL 700
    ENAIEFYGAI SHNKLHGLSV QVETNQVKLP SVVDGFASEG IIQFFFEETG 750
    DEKGFNIYIL DESNRAEVYH HCEGSKEELV RDVSRFYSSS HDRFTYGSSF 800
    INFNLPQFYQ IVKTDGRAQV IPFRTQPINT VPPANQDHDA PLLQQYFS 848
    Length:848
    Mass (Da):97,359
    Last modified:March 1, 2005 - v1
    Checksum:iEBA1E01E1AD60641
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti247 – 2471S → T no nucleotide entry 1 Publication
    Sequence conflicti321 – 3211R → G no nucleotide entry 1 Publication
    Sequence conflicti398 – 3981I → N no nucleotide entry 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF233324 Genomic DNA. Translation: AAF33452.1.
    AE006468 Genomic DNA. Translation: AAL22784.1.
    X55783 Genomic DNA. Translation: CAA39304.1.
    PIRiB31974.
    RefSeqiNP_462825.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL22784; AAL22784; STM3939.
    GeneIDi1255465.
    KEGGistm:STM3939.
    PATRICi32386741. VBISalEnt20916_4156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF233324 Genomic DNA. Translation: AAF33452.1 .
    AE006468 Genomic DNA. Translation: AAL22784.1 .
    X55783 Genomic DNA. Translation: CAA39304.1 .
    PIRi B31974.
    RefSeqi NP_462825.1. NC_003197.1.

    3D structure databases

    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 99287.STM3939.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL22784 ; AAL22784 ; STM3939 .
    GeneIDi 1255465.
    KEGGi stm:STM3939.
    PATRICi 32386741. VBISalEnt20916_4156.

    Phylogenomic databases

    eggNOGi COG3072.
    HOGENOMi HOG000270910.
    KOi K05851.
    OMAi SEGFLQF.
    OrthoDBi EOG63JR9H.
    PhylomeDBi P0A1A7.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-3968-MONOMER.

    Family and domain databases

    InterProi IPR000274. Adenylate_cyclase_1.
    IPR024686. Adenylate_cyclase_1_CS.
    IPR024685. Adenylate_cyclase_1_N.
    [Graphical view ]
    Pfami PF12633. Adenyl_cycl_N. 1 hit.
    PF01295. Adenylate_cycl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001444. Adenylate_cycl. 1 hit.
    PROSITEi PS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
    PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    2. "Isolation and characterization of a small catalytic domain released from the adenylate cyclase from Escherichia coli by digestion with trypsin."
      Holland M.M., Leib T.K., Gerlt J.A.
      J. Biol. Chem. 263:14661-14668(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-419.
    3. "Analysis of sequence elements important for expression and regulation of the adenylate cyclase gene (cya) of Salmonella typhimurium."
      Thorner L., Fandl J., Artz S.
      Genetics 125:709-717(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
      Strain: AZ3409.
    4. "Phylogeny of adenylyl cyclases."
      Danchin A.
      Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiCYAA_SALTY
    AccessioniPrimary (citable) accession number: P0A1A7
    Secondary accession number(s): Q05878
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2005
    Last modified: July 9, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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