P0A1A7 (CYAA_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate cyclase
EC=4.6.1.1

Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase

Gene names

Name:	cyaA
Synonyms:	cya
Ordered Locus Names:	STM3939
ORF Names:	STMD1.50

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	848 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Enzyme regulation	The regulatory domain is involved in the regulation of cyclase activity by the carbon source. Activated by the PTS system, glucose-specific IIA component (CRR).
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the adenylyl cyclase class-1 family.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Lyase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 848	848	Adenylate cyclase		PRO_0000195673
Regions
	Region	1 – 535	535	Catalytic
	Region	541 – 848	308	Regulatory
Amino acid modifications
	Modified residue	609	1	Phosphohistidine; by CRR Potential
Experimental info
	Sequence conflict	247	1	S → T no nucleotide entry Ref.2
	Sequence conflict	321	1	R → G no nucleotide entry Ref.2
	Sequence conflict	398	1	I → N no nucleotide entry Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P0A1A7 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: EBA1E01E1AD60641	FASTA	848	97,359
	10 20 30 40 50 60 MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPLMP GYLDGNVPSG 70 80 90 100 110 120 ICFYTPDETQ RHYLNELELY RGMTPQDPPK GELPITGVYT MGSTSSVGQS CSSDLDIWVC 130 140 150 160 170 180 HQSWLDGEER QLLQRKCSLL ESWAASLGVE VSFFLIDENR FRHNESGSLG GEDCGSTQHI 190 200 210 220 230 240 LLLDEFYRTA VRLAGKRILW SMVPCDEEEH YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA 250 260 270 280 290 300 EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL LAKDIKQRLH DGEIVSFGLD 310 320 330 340 350 360 PYCMMLERVT EYLTAIEDPT RLDLVRRCFY LKVCEKLSRE RACVGWRREV LSQLVSEWGW 370 380 390 400 410 420 DDARLTMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR 430 440 450 460 470 480 KLYAAFEALP GKVTLVNPQI SPDLSEPNLT FIHVPPGRAN RSGWYLYNRA PNMDSIISHQ 490 500 510 520 530 540 PLEYNRYLNK LVAWAWFNGL LTSRTHLFIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP 550 560 570 580 590 600 KALYSPCEIR HLAIIVNLEY DPTAAFRNKV VHFDFRKLDV FSFGEEQNCL IGSIDLLYRN 610 620 630 640 650 660 SWNEVRTLHF NGEQAMIEAL KTILGKMHQD AAPPDSVEVF CYSQHLRGLI RTRVQQLVSE 670 680 690 700 710 720 CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL ENAIEFYGAI SHNKLHGLSV 730 740 750 760 770 780 QVETNQVKLP SVVDGFASEG IIQFFFEETG DEKGFNIYIL DESNRAEVYH HCEGSKEELV 790 800 810 820 830 840 RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IVKTDGRAQV IPFRTQPINT VPPANQDHDA PLLQQYFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.
[2]	"Isolation and characterization of a small catalytic domain released from the adenylate cyclase from Escherichia coli by digestion with trypsin." Holland M.M., Leib T.K., Gerlt J.A. J. Biol. Chem. 263:14661-14668(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-419.
[3]	"Analysis of sequence elements important for expression and regulation of the adenylate cyclase gene (cya) of Salmonella typhimurium." Thorner L., Fandl J., Artz S. Genetics 125:709-717(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28. Strain: AZ3409.
[4]	"Phylogeny of adenylyl cyclases." Danchin A. Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF233324 Genomic DNA. Translation: AAF33452.1. AE006468 Genomic DNA. Translation: AAL22784.1. X55783 Genomic DNA. Translation: CAA39304.1.
PIR	B31974.
RefSeq	NP_462825.1. NC_003197.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM3939.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL22784; AAL22784; STM3939.
GeneID	1255465.
KEGG	stm:STM3939.
PATRIC	32386741. VBISalEnt20916_4156.
Phylogenomic databases
eggNOG	COG3072.
HOGENOM	HOG000270910.
KO	K05851.
OMA	LWQLYKG.
ProtClustDB	PRK09450.
Enzyme and pathway databases
BioCyc	SENT99287:GCTI-3968-MONOMER.
Family and domain databases
InterPro	IPR000274. Adenylate_cyclase_1. IPR024686. Adenylate_cyclase_1_CS. IPR024685. Adenylate_cyclase_1_N. [Graphical view]
Pfam	PF12633. Adenyl_cycl_N. 1 hit. PF01295. Adenylate_cycl. 1 hit. [Graphical view]
PIRSF	PIRSF001444. Adenylate_cycl. 1 hit.
PROSITE	PS01092. ADENYLATE_CYCLASE_1_1. 1 hit. PS01093. ADENYLATE_CYCLASE_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_SALTY

Accession

Primary (citable) accession number: P0A1A7
Secondary accession number(s): Q05878

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	May 29, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program