ID   NAHB_PSEU8              Reviewed;         259 AA.
AC   P0A170; O33462; Q52459;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=1,2-dihydroxy-1,2-dihydronaphthalene dehydrogenase;
DE            EC=1.3.1.29;
DE   AltName: Full=Cis-naphthalene dihydrodiol dehydrogenase;
DE   AltName: Full=Dibenzothiophene dihydrodiol dehydrogenase;
DE            EC=1.3.1.60;
GN   Name=doxE;
OS   Pseudomonas sp. (strain C18).
OG   Plasmid.
OC   Bacteria; Proteobacteria.
OX   NCBI_TaxID=69011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=94042852; PubMed=8226631;
RA   Denome S.A., Stanley D.C., Olson E.S., Young K.D.;
RT   "Metabolism of dibenzothiophene and naphthalene in Pseudomonas
RT   strains: complete DNA sequence of an upper naphthalene catabolic
RT   pathway.";
RL   J. Bacteriol. 175:6890-6901(1993).
CC   -!- FUNCTION: Catalyzes the oxidation of naphthalene dihydrodiol into
CC       1,2-dihydroxynaphthalene.
CC   -!- CATALYTIC ACTIVITY: Cis-1,2-dihydronaphthalene-1,2-diol + NAD(+) =
CC       naphthalene-1,2-diol + NADH.
CC   -!- CATALYTIC ACTIVITY: Cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene
CC       + NAD(+) = 1,2-dihydroxydibenzothiophene + NADH.
CC   -!- PATHWAY: Aromatic compound metabolism; naphtalene degradation.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; M60405; AAA16128.1; ALT_INIT; Genomic_DNA.
DR   HSSP; P47227; 1BDB.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0018505; F:cis-1,2-dihydro-1,2-dihydroxynaphthalene de...; IEA:EC.
DR   GO; GO:0018513; F:dibenzothiophene dihydrodiol dehydrogenase ...; IEA:EC.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; FALSE_NEG.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase; Plasmid.
FT   CHAIN         1    259       1,2-dihydroxy-1,2-dihydronaphthalene
FT                                dehydrogenase.
FT                                /FTId=PRO_0000054731.
FT   NP_BIND       8     32       NAD (By similarity).
FT   ACT_SITE    153    153       Proton acceptor (By similarity).
FT   BINDING     140    140       Substrate (By similarity).
SQ   SEQUENCE   259 AA;  27528 MW;  B77E517D88789380 CRC64;
     MGNQQVVSIT GAGSGIGLEL VRSFKSAGYY VSALVRNEEQ EALLCKEFKD ALEIVVGDVR
     DHATNEKLIK QTIDRFGHLD CFIANAGIWD YMLSIEEPWE KISSSFDEIF DINVKSYFSG
     ISAALPELKK TNGSVVMTAS VSSHAVGGGG SCYIASKHAV LGMVKALAYE LAPEVRVNAV
     SPGGTVTSLC GPASAGFDKM HMKDMPGIDD MIKGLTPLGF AAKPEDVVAP YLLLASRKQG
     KFITGTVISI DGGMALGRK
//