P0A170 (NAHB_PSEU8) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 35.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 1,2-dihydroxy-1,2-dihydronaphthalene dehydrogenase EC=1.3.1.29 Alternative name(s): Cis-naphthalene dihydrodiol dehydrogenase Dibenzothiophene dihydrodiol dehydrogenase EC=1.3.1.60 | ||
| Gene names |
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| Encoded on | Plasmid | ||
| Organism | Pseudomonas sp. (strain C18) | ||
| Taxonomic identifier | 69011 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria |
Protein attributes
| Sequence length | 259 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the oxidation of naphthalene dihydrodiol into 1,2-dihydroxynaphthalene. |
| Catalytic activity | Cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH. Cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ = 1,2-dihydroxydibenzothiophene + NADH. |
| Pathway | |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| Sequence caution | The sequence AAA16128.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Aromatic hydrocarbons catabolism |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Plasmid |
| Gene Ontology (GO) | |
| Biological process | aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity Inferred from electronic annotation. Source: EC dibenzothiophene dihydrodiol dehydrogenase activityInferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 259 | 259 | 1,2-dihydroxy-1,2-dihydronaphthalene dehydrogenase | PRO_0000054731 | |||||
Regions | |||||||||
| Nucleotide binding | 8 – 32 | 25 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 153 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 140 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Metabolism of dibenzothiophene and naphthalene in Pseudomonas strains: complete DNA sequence of an upper naphthalene catabolic pathway." Denome S.A., Stanley D.C., Olson E.S., Young K.D. J. Bacteriol. 175:6890-6901(1993) [PubMed: 8226631] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M60405 Genomic DNA. Translation: AAA16128.1. Different initiation. |
3D structure databases | |
| ProteinModelPortal | P0A170. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PRINTS | PR00081. GDHRDH. PR00080. SDRFAMILY. |
| PROSITE | PS00061. ADH_SHORT. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NAHB_PSEU8 | ||||||||
| Accession | Primary (citable) accession number: P0A170 Secondary accession number(s): O33462, Q52459 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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