Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

1,2-dihydroxynaphthalene dioxygenase

Gene

doxG

Organism
Pseudomonas sp. (strain C18)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the naphthalene catabolic pathway. Catalyzes the meta-cleavage of 1,2-dihydroxynaphthalene (1,2-DHN) to yield 2-hydroxychromene-2-carboxylic acid (By similarity).By similarity

Catalytic activityi

Naphthalene-1,2-diol + O2 = 2-hydroxy-2H-chromene-2-carboxylate.

Cofactori

Fe2+1 Publication

Pathwayi: naphthalene degradation

This protein is involved in the pathway naphthalene degradation, which is part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the pathway naphthalene degradation and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi152Iron1
Binding sitei152Substrate1
Metal bindingi215Iron1
Binding sitei215Substrate1
Binding sitei256Substrate1
Metal bindingi266Iron1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00082.

Names & Taxonomyi

Protein namesi
Recommended name:
1,2-dihydroxynaphthalene dioxygenase (EC:1.13.11.56)
Short name:
1,2-DHN dioxygenase
Short name:
DHNDO
Alternative name(s):
1,2-dihydroxynaphthalene oxygenase
Gene namesi
Name:doxG
Encoded oniPlasmid unnamed1 Publication
OrganismiPseudomonas sp. (strain C18)
Taxonomic identifieri69011 [NCBI]
Taxonomic lineageiBacteriaProteobacteria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000850231 – 3021,2-dihydroxynaphthalene dioxygenaseAdd BLAST302

Structurei

Secondary structure

1302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 16Combined sources10
Helixi20 – 29Combined sources10
Beta strandi34 – 36Combined sources3
Beta strandi41 – 52Combined sources12
Beta strandi54 – 60Combined sources7
Beta strandi63 – 74Combined sources12
Helixi75 – 87Combined sources13
Helixi97 – 103Combined sources7
Beta strandi105 – 112Combined sources8
Beta strandi118 – 125Combined sources8
Helixi146 – 148Combined sources3
Beta strandi152 – 155Combined sources4
Helixi160 – 169Combined sources10
Beta strandi176 – 181Combined sources6
Beta strandi187 – 199Combined sources13
Beta strandi201 – 204Combined sources4
Beta strandi210 – 222Combined sources13
Helixi223 – 235Combined sources13
Beta strandi240 – 246Combined sources7
Turni248 – 250Combined sources3
Beta strandi253 – 258Combined sources6
Beta strandi262 – 269Combined sources8
Beta strandi281 – 283Combined sources3
Beta strandi285 – 287Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EHZX-ray1.35A1-302[»]
2EI0X-ray1.60A1-302[»]
2EI1X-ray1.52A1-302[»]
2EI2X-ray1.69A1-302[»]
2EI3X-ray1.90A1-302[»]
ProteinModelPortaliP0A108.
SMRiP0A108.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A108.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 200Substrate binding2

Sequence similaritiesi

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
IPR000486. Xdiol_ring_cleave_dOase_1/2.
[Graphical view]
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.
PROSITEiPS00082. EXTRADIOL_DIOXYGENAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQAAVIEL GYMGISVKDP DAWKSFATDM LGLQVLDEGE KDRFYLRMDY
60 70 80 90 100
WHHRIVVHHN GQDDLEYLGW RVAGKPEFEA LGQKLIDAGY KIRICDKVEA
110 120 130 140 150
QERMVLGLMK TEDPGGNPTE IFWGPRIDMS NPFHPGRPLH GKFVTGDQGL
160 170 180 190 200
GHCIVRQTDV AEAHKFYSLL GFRGDVEYRI PLPNGMTAEL SFMHCNARDH
210 220 230 240 250
SIAFGAMPAA KRLNHLMLEY THMEDLGYTH QQFVKNEIDI ALQLGIHAND
260 270 280 290 300
KALTFYGATP SGWLIEPGWR GATAIDEAEY YVGDIFGHGV EATGYGLDVK

LS
Length:302
Mass (Da):33,942
Last modified:March 1, 2005 - v1
Checksum:iC2A3DAECFB6FB833
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60405 Genomic DNA. Translation: AAA16130.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60405 Genomic DNA. Translation: AAA16130.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EHZX-ray1.35A1-302[»]
2EI0X-ray1.60A1-302[»]
2EI1X-ray1.52A1-302[»]
2EI2X-ray1.69A1-302[»]
2EI3X-ray1.90A1-302[»]
ProteinModelPortaliP0A108.
SMRiP0A108.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00082.

Miscellaneous databases

EvolutionaryTraceiP0A108.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
IPR000486. Xdiol_ring_cleave_dOase_1/2.
[Graphical view]
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.
PROSITEiPS00082. EXTRADIOL_DIOXYGENAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAHC_PSEU8
AccessioniPrimary (citable) accession number: P0A108
Secondary accession number(s): Q57145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded on an unnamed 75 kb plasmid.1 Publication

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.