P0A107 (NAHC_PSEAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1,2-dihydroxynaphthalene dioxygenase
EC=1.13.11.-

Gene names

Name:	nahC
Synonyms:	pahC

Organism

Pseudomonas aeruginosa

Taxonomic identifier

287 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the meta-cleavage of the substrate's aromatic ring By similarity.
Cofactor	Fe2+ ion By similarity.
Pathway	Aromatic compound metabolism; naphthalene degradation.
Sequence similarities	Belongs to the extradiol ring-cleavage dioxygenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ferrous iron binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	1,2-dihydroxynaphthalene dioxygenase		PRO_0000085020
Sites
	Metal binding	152	1	Iron By similarity
	Metal binding	215	1	Iron By similarity
	Metal binding	266	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A107 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: C2A3DAECFB6FB833	FASTA	302	33,942
	10 20 30 40 50 60 MSKQAAVIEL GYMGISVKDP DAWKSFATDM LGLQVLDEGE KDRFYLRMDY WHHRIVVHHN 70 80 90 100 110 120 GQDDLEYLGW RVAGKPEFEA LGQKLIDAGY KIRICDKVEA QERMVLGLMK TEDPGGNPTE 130 140 150 160 170 180 IFWGPRIDMS NPFHPGRPLH GKFVTGDQGL GHCIVRQTDV AEAHKFYSLL GFRGDVEYRI 190 200 210 220 230 240 PLPNGMTAEL SFMHCNARDH SIAFGAMPAA KRLNHLMLEY THMEDLGYTH QQFVKNEIDI 250 260 270 280 290 300 ALQLGIHAND KALTFYGATP SGWLIEPGWR GATAIDEAEY YVGDIFGHGV EATGYGLDVK LS

References

[1]	"The molecular analysis of an NAH7-type gene cluster, pah, located on the chromosome of Pseudomonas aeruginosa PaK1." Takizawa N., Iida T., Yamauchi K., Satoh S., Wang Y., Fukuda M., Kiyohara H. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: PaK1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D84146 Genomic DNA. Translation: BAA12244.1.
3D structure databases
ProteinModelPortal	P0A107.
SMR	P0A107. Positions 4-302.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004360. Glyas_Fos-R_dOase. IPR000486. Xdiol_ring_cleave_dOase_1/2. [Graphical view]
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PROSITE	PS00082. EXTRADIOL_DIOXYGENAS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAHC_PSEAI

Accession

Primary (citable) accession number: P0A107
Secondary accession number(s): Q57145

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	November 16, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program