Reviewed, UniProtKB/Swiss-Prot P0A100 (ARGA_PSEPU)

Names and origin

Protein names

Recommended name:
    Amino-acid acetyltransferase
    EC=2.3.1.1
Alternative name(s):
    N-acetylglutamate synthase
      Short name=AGS
      Short name=NAGS

Gene names

Name:

argA

Organism

Pseudomonas putida

Taxonomic identifier

303 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.
Sequence caution	The sequence M38359 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	amino-acid N-acetyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	Amino-acid acetyltransferase HAMAP MF_01105		PRO_0000186800
Regions
	Domain	286 – 432	147	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	P0A100-1 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: BFB889B705F22450	FASTA	432	47,440
	10 20 30 40 50 60 MPDYVNWLRH ASPYINAHRD CTFVVMLPGD GVEHPNFGNI VHDLVLLHSL GVRLVLVHGS 70 80 90 100 110 120 RPQIESRLAD RGLTPHYHRG MRITDAATLD CVIDAVGALR LAIEARLSMD IAASPMQGSR 130 140 150 160 170 180 LRVASGNLVT ARPIGVLEGV DYHHTGEVRR VDRKGISRLL DERSIVLLSP LGYSPTGEIF 190 200 210 220 230 240 NLACEDVATR AAIELGADKL LLFGAEPGLL DADGRLVREL RPQQVAPHLQ RLGSDYQGEL 250 260 270 280 290 300 LDAAAEACKG GVARSHIVSY AEDGALLTEL FTRGGGGTLV SQEQFEVVRE ATIEDVGGLL 310 320 330 340 350 360 ELISPLEEQG ILVRRSREVL EREIEQFSVV EREGMIIACA ALYPIADSEA GELACLAVNP 370 380 390 400 410 420 EYRHGGRGDE LLERIESRAR QMGLSTLFVL TTRTAHWFRE RGFAPSGVER LPAARASLYN 430 YQRNSKIFEK PL

References

[1]	Dharmsthiti S., Krishnapillai V. Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: PPN.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M38359 Genomic DNA. No translation available.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.3.1.1. 403.
Family and domain databases
HAMAP	MF_01105. [Tree]
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR000182. GCN5-rel_AcTrfase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_PSEPU

Accession

Primary (citable) accession number: P0A100
Secondary accession number(s): P32042

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)