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Protein

N-acylneuraminate cytidylyltransferase

Gene

neuA

Organism
Neisseria meningitidis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.7.7.43. 3593.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acylneuraminate cytidylyltransferase (EC:2.7.7.43)
Alternative name(s):
CMP-N-acetylneuraminic acid synthase
Short name:
CMP-NeuNAc synthase
CMP-sialic acid synthase
Gene namesi
Name:neuA
Synonyms:siaB, synB
OrganismiNeisseria meningitidis
Taxonomic identifieri487 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228N-acylneuraminate cytidylyltransferasePRO_0000213206Add
BLAST

Proteomic databases

PaxDbiP0A0Z8.

Interactioni

Protein-protein interaction databases

STRINGi122586.NMB0069.

Structurei

Secondary structure

1
228
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 107Combined sources
Beta strandi16 – 183Combined sources
Turni19 – 235Combined sources
Helixi31 – 4212Combined sources
Beta strandi46 – 538Combined sources
Helixi55 – 639Combined sources
Beta strandi67 – 704Combined sources
Helixi73 – 764Combined sources
Helixi81 – 9313Combined sources
Beta strandi97 – 1026Combined sources
Helixi112 – 1198Combined sources
Turni124 – 1263Combined sources
Beta strandi130 – 1356Combined sources
Beta strandi144 – 1463Combined sources
Beta strandi148 – 1503Combined sources
Beta strandi152 – 1565Combined sources
Helixi158 – 1614Combined sources
Helixi165 – 1673Combined sources
Beta strandi171 – 18212Combined sources
Helixi183 – 1897Combined sources
Beta strandi198 – 2014Combined sources
Helixi205 – 2073Combined sources
Helixi213 – 22311Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EYRX-ray2.20A/B1-228[»]
1EZIX-ray2.00A/B1-228[»]
ProteinModelPortaliP0A0Z8.
SMRiP0A0Z8. Positions 1-225.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0Z8.

Family & Domainsi

Sequence similaritiesi

Belongs to the CMP-NeuNAc synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105F0R. Bacteria.
COG1083. LUCA.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003329. Cytidylyl_trans.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A0Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKQNIAVIL ARQNSKGLPL KNLRKMNGIS LLGHTINAAI SSKCFDRIIV
60 70 80 90 100
STDGGLIAEE AKNFGVEVVL RPAELASDTA SSISGVIHAL ETIGSNSGTV
110 120 130 140 150
TLLQPTSPLR TGAHIREAFS LFDEKIKGSV VSACPMEHHP LKTLLQINNG
160 170 180 190 200
EYAPMRHLSD LEQPRQQLPQ AFRPNGAIYI NDTASLIANN CFFIAPTKLY
210 220
IMSHQDSIDI DTELDLQQAE NILNHKES
Length:228
Mass (Da):24,892
Last modified:February 15, 2005 - v1
Checksum:iF2510733EE1C3A31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60146 Genomic DNA. Translation: AAB60780.1.
RefSeqiWP_002215295.1. NZ_KQ236530.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60146 Genomic DNA. Translation: AAB60780.1.
RefSeqiWP_002215295.1. NZ_KQ236530.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EYRX-ray2.20A/B1-228[»]
1EZIX-ray2.00A/B1-228[»]
ProteinModelPortaliP0A0Z8.
SMRiP0A0Z8. Positions 1-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi122586.NMB0069.

Proteomic databases

PaxDbiP0A0Z8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105F0R. Bacteria.
COG1083. LUCA.

Enzyme and pathway databases

BRENDAi2.7.7.43. 3593.

Miscellaneous databases

EvolutionaryTraceiP0A0Z8.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003329. Cytidylyl_trans.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Purification and characterization of the recombinant CMP-sialic acid synthetase from Neisseria meningitidis."
    Gilbert M., Watson D.C., Wakarchuk W.W.
    Biotechnol. Lett. 19:417-420(1997)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NRCC 4030 / 406Y / Serogroup Y.

Entry informationi

Entry nameiNEUA_NEIME
AccessioniPrimary (citable) accession number: P0A0Z8
Secondary accession number(s): Q57385
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 11, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.