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Protein

N-acylneuraminate cytidylyltransferase

Gene

neuA

Organism
Neisseria meningitidis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.7.7.43. 3593.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acylneuraminate cytidylyltransferase (EC:2.7.7.43)
Alternative name(s):
CMP-N-acetylneuraminic acid synthase
Short name:
CMP-NeuNAc synthase
CMP-sialic acid synthase
Gene namesi
Name:neuA
Synonyms:siaB, synB
OrganismiNeisseria meningitidis
Taxonomic identifieri487 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002132061 – 228N-acylneuraminate cytidylyltransferaseAdd BLAST228

Proteomic databases

PaxDbiP0A0Z8.

Interactioni

Protein-protein interaction databases

STRINGi122586.NMB0069.

Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 10Combined sources7
Beta strandi16 – 18Combined sources3
Turni19 – 23Combined sources5
Helixi31 – 42Combined sources12
Beta strandi46 – 53Combined sources8
Helixi55 – 63Combined sources9
Beta strandi67 – 70Combined sources4
Helixi73 – 76Combined sources4
Helixi81 – 93Combined sources13
Beta strandi97 – 102Combined sources6
Helixi112 – 119Combined sources8
Turni124 – 126Combined sources3
Beta strandi130 – 135Combined sources6
Beta strandi144 – 146Combined sources3
Beta strandi148 – 150Combined sources3
Beta strandi152 – 156Combined sources5
Helixi158 – 161Combined sources4
Helixi165 – 167Combined sources3
Beta strandi171 – 182Combined sources12
Helixi183 – 189Combined sources7
Beta strandi198 – 201Combined sources4
Helixi205 – 207Combined sources3
Helixi213 – 223Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EYRX-ray2.20A/B1-228[»]
1EZIX-ray2.00A/B1-228[»]
ProteinModelPortaliP0A0Z8.
SMRiP0A0Z8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0Z8.

Family & Domainsi

Sequence similaritiesi

Belongs to the CMP-NeuNAc synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105F0R. Bacteria.
COG1083. LUCA.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003329. Cytidylyl_trans.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A0Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKQNIAVIL ARQNSKGLPL KNLRKMNGIS LLGHTINAAI SSKCFDRIIV
60 70 80 90 100
STDGGLIAEE AKNFGVEVVL RPAELASDTA SSISGVIHAL ETIGSNSGTV
110 120 130 140 150
TLLQPTSPLR TGAHIREAFS LFDEKIKGSV VSACPMEHHP LKTLLQINNG
160 170 180 190 200
EYAPMRHLSD LEQPRQQLPQ AFRPNGAIYI NDTASLIANN CFFIAPTKLY
210 220
IMSHQDSIDI DTELDLQQAE NILNHKES
Length:228
Mass (Da):24,892
Last modified:February 15, 2005 - v1
Checksum:iF2510733EE1C3A31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60146 Genomic DNA. Translation: AAB60780.1.
RefSeqiWP_002215295.1. NZ_LWLO01000038.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60146 Genomic DNA. Translation: AAB60780.1.
RefSeqiWP_002215295.1. NZ_LWLO01000038.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EYRX-ray2.20A/B1-228[»]
1EZIX-ray2.00A/B1-228[»]
ProteinModelPortaliP0A0Z8.
SMRiP0A0Z8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi122586.NMB0069.

Proteomic databases

PaxDbiP0A0Z8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105F0R. Bacteria.
COG1083. LUCA.

Enzyme and pathway databases

BRENDAi2.7.7.43. 3593.

Miscellaneous databases

EvolutionaryTraceiP0A0Z8.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003329. Cytidylyl_trans.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNEUA_NEIME
AccessioniPrimary (citable) accession number: P0A0Z8
Secondary accession number(s): Q57385
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.