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P0A0X4 (RS12_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
30S ribosomal protein S12
Gene names
Name:rpsL
Ordered Locus Names:HP_1197
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length135 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

With S4 and S5 plays an important role in translational accuracy By similarity. HAMAP-Rule MF_00403_B

Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit By similarity. HAMAP-Rule MF_00403_B

Subunit structure

Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex By similarity.

Sequence similarities

Belongs to the ribosomal protein S12P family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

rimPO256873EBI-7607319,EBI-7605525

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13513530S ribosomal protein S12 HAMAP-Rule MF_00403_B
PRO_0000146235

Amino acid modifications

Modified residue8913-methylthioaspartic acid By similarity

Natural variations

Natural variant431K → R in strain: CCUG 17874; streptomycin resistant.

Sequences

Sequence LengthMass (Da)Tools
P0A0X4 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 909C91470EB19959

FASTA13515,106
        10         20         30         40         50         60 
MPTINQLIRK ERKKVVKKTK SPALVECPQR RGVCTRVYTT TPKKPNSALR KVAKVRLTSK 

        70         80         90        100        110        120 
FEVISYIPGE GHNLQEHSIV LVRGGRVKDL PGVKYHIVRG ALDTAGVNKR TVSRSKYGTK 

       130 
KAKATDKKAT DNKKK 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.
[2]"Mutations affecting the colonizing-potential of Helicobacter pylori map within the cag pathogenicity island."
Marchetti M., Censini S., Ghiara P., Rappuoli R., Covacci A.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (OF A STREPTOMYCIN RESISTANT VARIANT).
Strain: DSM 4867 / CCUG 17874 / NCTC 11638.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08241.1.
U96106 Genomic DNA. Translation: AAD00825.1.
PIRE64669.
RefSeqNP_207988.1. NC_000915.1.
YP_006935116.1. NC_018939.1.

3D structure databases

ProteinModelPortalP0A0X4.
SMRP0A0X4. Positions 1-123.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP0A0X4. 3 interactions.
MINTMINT-160916.
STRING85962.HP1197.

Proteomic databases

PRIDEP0A0X4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08241; AAD08241; HP_1197.
GeneID899959.
KEGGheo:C694_06190.
hpy:HP1197.
PATRIC20593751. VBIHelPyl33062_1253.

Phylogenomic databases

eggNOGCOG0048.
KOK02950.
OMAVARSKYG.
OrthoDBEOG61ZTNF.

Enzyme and pathway databases

BioCycHPY:HP1197-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_00403_B. Ribosomal_S12_B.
InterProIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERPTHR11652. PTHR11652. 1 hit.
PfamPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSPR01034. RIBOSOMALS12.
SUPFAMSSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00981. rpsL_bact. 1 hit.
PROSITEPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRS12_HELPY
AccessionPrimary (citable) accession number: P0A0X4
Secondary accession number(s): P56019, Q9R787
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names