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P0A0X4

- RS12_HELPY

UniProt

P0A0X4 - RS12_HELPY

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Protein

30S ribosomal protein S12

Gene

rpsL

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

With S4 and S5 plays an important role in translational accuracy.By similarity
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).By similarity

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
  2. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Enzyme and pathway databases

BioCyciHPY:HP1197-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S12
Gene namesi
Name:rpsL
Ordered Locus Names:HP_1197
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. small ribosomal subunit Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13513530S ribosomal protein S12PRO_0000146235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 8913-methylthioaspartic acidBy similarity

Proteomic databases

PRIDEiP0A0X4.

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
rimPO256873EBI-7607319,EBI-7605525

Protein-protein interaction databases

IntActiP0A0X4. 3 interactions.
MINTiMINT-160916.
STRINGi85962.HP1197.

Structurei

3D structure databases

ProteinModelPortaliP0A0X4.
SMRiP0A0X4. Positions 1-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12P family.Curated

Phylogenomic databases

eggNOGiCOG0048.
KOiK02950.
OMAiVARSKYG.
OrthoDBiEOG61ZTNF.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00403_B. Ribosomal_S12_B.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A0X4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTINQLIRK ERKKVVKKTK SPALVECPQR RGVCTRVYTT TPKKPNSALR
60 70 80 90 100
KVAKVRLTSK FEVISYIPGE GHNLQEHSIV LVRGGRVKDL PGVKYHIVRG
110 120 130
ALDTAGVNKR TVSRSKYGTK KAKATDKKAT DNKKK
Length:135
Mass (Da):15,106
Last modified:March 1, 2005 - v1
Checksum:i909C91470EB19959
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431K → R in strain: CCUG 17874; streptomycin resistant.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08241.1.
U96106 Genomic DNA. Translation: AAD00825.1.
PIRiE64669.
RefSeqiNP_207988.1. NC_000915.1.
YP_006935116.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08241; AAD08241; HP_1197.
GeneIDi13870396.
899959.
KEGGiheo:C694_06190.
hpy:HP1197.
PATRICi20593751. VBIHelPyl33062_1253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08241.1 .
U96106 Genomic DNA. Translation: AAD00825.1 .
PIRi E64669.
RefSeqi NP_207988.1. NC_000915.1.
YP_006935116.1. NC_018939.1.

3D structure databases

ProteinModelPortali P0A0X4.
SMRi P0A0X4. Positions 1-123.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P0A0X4. 3 interactions.
MINTi MINT-160916.
STRINGi 85962.HP1197.

Proteomic databases

PRIDEi P0A0X4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08241 ; AAD08241 ; HP_1197 .
GeneIDi 13870396.
899959.
KEGGi heo:C694_06190.
hpy:HP1197.
PATRICi 20593751. VBIHelPyl33062_1253.

Phylogenomic databases

eggNOGi COG0048.
KOi K02950.
OMAi VARSKYG.
OrthoDBi EOG61ZTNF.

Enzyme and pathway databases

BioCyci HPY:HP1197-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00403_B. Ribosomal_S12_B.
InterProi IPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view ]
PANTHERi PTHR11652. PTHR11652. 1 hit.
Pfami PF00164. Ribosom_S12_S23. 1 hit.
[Graphical view ]
PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSi PR01034. RIBOSOMALS12.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00981. rpsL_bact. 1 hit.
PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. "Mutations affecting the colonizing-potential of Helicobacter pylori map within the cag pathogenicity island."
    Marchetti M., Censini S., Ghiara P., Rappuoli R., Covacci A.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (OF A STREPTOMYCIN RESISTANT VARIANT).
    Strain: DSM 4867 / CCUG 17874 / NCTC 11638.
  3. "A minimal bacterial RNase J-based degradosome is associated with translating ribosomes."
    Redko Y., Aubert S., Stachowicz A., Lenormand P., Namane A., Darfeuille F., Thibonnier M., De Reuse H.
    Nucleic Acids Res. 41:288-301(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiRS12_HELPY
AccessioniPrimary (citable) accession number: P0A0X4
Secondary accession number(s): P56019, Q9R787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3