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P0A0U9

- PBP2_NEIMB

UniProt

P0A0U9 - PBP2_NEIMB

Protein

Penicillin-binding protein 2

Gene

penA

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Synthesis of cross-linked peptidoglycan from the lipid intermediates.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei310 – 3101Acyl-ester intermediate

    GO - Molecular functioni

    1. catalytic activity Source: UniProtKB-KW
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    4. regulation of cell shape Source: UniProtKB-KW
    5. response to antibiotic Source: UniProtKB-KW

    Keywords - Biological processi

    Antibiotic resistance, Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciNMEN122586:GHGG-437-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Penicillin-binding protein 2
    Short name:
    PBP-2
    Gene namesi
    Name:penA
    Ordered Locus Names:NMB0413
    OrganismiNeisseria meningitidis serogroup B (strain MC58)
    Taxonomic identifieri122586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000000425: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 581581Penicillin-binding protein 2PRO_0000195452Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi122586.NMB0413.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A0U9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The enzyme has an N-terminal penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a C-terminal penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).

    Sequence similaritiesi

    Belongs to the transpeptidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0768.
    HOGENOMiHOG000049554.
    KOiK03587.
    OMAiPDGKYIN.
    OrthoDBiEOG6N0HHV.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A0U9-1 [UniParc]FASTAAdd to Basket

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    MLIKSEYKPR MLPKEEQVKK PMTSNGRISF VLMAIAVLFA GLIARGLYLQ    50
    TVTYNFLKEQ GDNRIVRTQT LPATRGTVSD RNGAVLALSA PTESLFAVPK 100
    EMKEMPSAAQ LERLSELVDV PVDVLRNKLE QKGKSFIWIK RQLDPKVAEE 150
    VKALGLENFV FEKELKRHYP MGNLFAHVIG FTDIDGKGQE GLELSLEDSL 200
    HGEDGAEVVL RDRQGNIVDS LDSPRNKAPK NGKDIILSLD QRIQTLAYEE 250
    LNKAVEYHQA KAGTVVVLDA RTGEILALAN TPAYDPNRPG RADSEQRRNR 300
    AVTDMIEPGS AIKPFVIAKA LDAGKTDLNE RLNTQPYKIG PSPVRDTHVY 350
    PSLDVRGIMQ KSSNVGTSKL SARFGAEEMY DFYHELGIGV RMHSGFPGET 400
    AGLLRNWRRW RPIEQATMSF GYGLQLSLLQ LARAYTALTH DGVLLPVSFE 450
    KQAVAPQGKR IFKESTAREV RNLMVSVTEP GGTGTAGAVD GFDVGAKTGT 500
    ARKFVNGRYA DNKHIATFIG FAPAKNPRVI VAVTIDEPTA HGYYGGVVAG 550
    PPFKKIMGGS LNILGISPTK PLTAAAVKTP S 581
    Length:581
    Mass (Da):63,604
    Last modified:March 1, 2005 - v1
    Checksum:iBABC396F205D2F6B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15276 Genomic DNA. Translation: CAA33347.1.
    AE002098 Genomic DNA. Translation: AAF40852.1.
    PIRiS04857.
    RefSeqiNP_273462.1. NC_003112.2.
    WP_002218783.1. NC_003112.2.

    Genome annotation databases

    EnsemblBacteriaiAAF40852; AAF40852; NMB0413.
    GeneIDi902529.
    KEGGinme:NMB0413.
    PATRICi20356015. VBINeiMen85645_0523.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15276 Genomic DNA. Translation: CAA33347.1 .
    AE002098 Genomic DNA. Translation: AAF40852.1 .
    PIRi S04857.
    RefSeqi NP_273462.1. NC_003112.2.
    WP_002218783.1. NC_003112.2.

    3D structure databases

    ProteinModelPortali P0A0U9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 122586.NMB0413.

    Protocols and materials databases

    DNASUi 902529.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF40852 ; AAF40852 ; NMB0413 .
    GeneIDi 902529.
    KEGGi nme:NMB0413.
    PATRICi 20356015. VBINeiMen85645_0523.

    Phylogenomic databases

    eggNOGi COG0768.
    HOGENOMi HOG000049554.
    KOi K03587.
    OMAi PDGKYIN.
    OrthoDBi EOG6N0HHV.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci NMEN122586:GHGG-437-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the penicillin-binding protein 2 gene of Neisseria meningitidis."
      Xhang Q.-Y., Spratt B.G.
      Nucleic Acids Res. 17:5383-5383(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C311 / Serogroup B.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC58.

    Entry informationi

    Entry nameiPBP2_NEIMB
    AccessioniPrimary (citable) accession number: P0A0U9
    Secondary accession number(s): P11882
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3