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P0A0U8 (PBP2_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Penicillin-binding protein 2

Short name=PBP-2
Gene names
Name:penA
Ordered Locus Names:NMA2072
OrganismNeisseria meningitidis serogroup A / serotype 4A (strain Z2491) [Complete proteome] [HAMAP]
Taxonomic identifier122587 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length581 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Synthesis of cross-linked peptidoglycan from the lipid intermediates By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cell inner membrane By similarity.

Domain

The enzyme has an N-terminal penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a C-terminal penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits) By similarity.

Sequence similarities

Belongs to the transpeptidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 581581Penicillin-binding protein 2
PRO_0000195451

Sites

Active site3101Acyl-ester intermediate

Sequences

Sequence LengthMass (Da)Tools
P0A0U8 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: BABC396F205D2F6B

FASTA58163,604
        10         20         30         40         50         60 
MLIKSEYKPR MLPKEEQVKK PMTSNGRISF VLMAIAVLFA GLIARGLYLQ TVTYNFLKEQ 

        70         80         90        100        110        120 
GDNRIVRTQT LPATRGTVSD RNGAVLALSA PTESLFAVPK EMKEMPSAAQ LERLSELVDV 

       130        140        150        160        170        180 
PVDVLRNKLE QKGKSFIWIK RQLDPKVAEE VKALGLENFV FEKELKRHYP MGNLFAHVIG 

       190        200        210        220        230        240 
FTDIDGKGQE GLELSLEDSL HGEDGAEVVL RDRQGNIVDS LDSPRNKAPK NGKDIILSLD 

       250        260        270        280        290        300 
QRIQTLAYEE LNKAVEYHQA KAGTVVVLDA RTGEILALAN TPAYDPNRPG RADSEQRRNR 

       310        320        330        340        350        360 
AVTDMIEPGS AIKPFVIAKA LDAGKTDLNE RLNTQPYKIG PSPVRDTHVY PSLDVRGIMQ 

       370        380        390        400        410        420 
KSSNVGTSKL SARFGAEEMY DFYHELGIGV RMHSGFPGET AGLLRNWRRW RPIEQATMSF 

       430        440        450        460        470        480 
GYGLQLSLLQ LARAYTALTH DGVLLPVSFE KQAVAPQGKR IFKESTAREV RNLMVSVTEP 

       490        500        510        520        530        540 
GGTGTAGAVD GFDVGAKTGT ARKFVNGRYA DNKHIATFIG FAPAKNPRVI VAVTIDEPTA 

       550        560        570        580 
HGYYGGVVAG PPFKKIMGGS LNILGISPTK PLTAAAVKTP S 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL157959 Genomic DNA. Translation: CAM09174.1.
PIRS04857.
RefSeqYP_002343330.1. NC_003116.1.

3D structure databases

ProteinModelPortalP0A0U8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING122587.NMA2072.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM09174; CAM09174; NMA2072.
GeneID907370.
KEGGnma:NMA2072.
PATRIC20365612. VBINeiMen132687_2498.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0768.
HOGENOMHOG000049554.
KOK03587.
OMAKINQLGK.
OrthoDBEOG6N0HHV.

Enzyme and pathway databases

BioCycNMEN122587:GI3Q-1907-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
ProtoNetSearch...

Entry information

Entry namePBP2_NEIMA
AccessionPrimary (citable) accession number: P0A0U8
Secondary accession number(s): A1ITQ6, P11882
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways