P0A0T1 (G6PI_XANCI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:

pgi

Organism

Xanthomonas campestris pv. citri (Xanthomonas citri)

Taxonomic identifier

346 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for pathogenicity. HAMAP MF_00473
Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Induction	Inhibited by growth in complex medium but induced by culture in plant extract. HAMAP MF_00473
Miscellaneous	Mutation in pgi results in the inability of X.c.citri to utilize fructose or glycerol as carbon sources, to grow in plant tissue, and to cause typical canker symptoms. HAMAP MF_00473
Sequence similarities	Belongs to the GPI family.
Sequence caution	The sequence AAC08426.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 504	504	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180771
Sites
	Active site	333	1	Proton donor By similarity
	Active site	364	1	By similarity
	Active site	473	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A0T1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 03C410C3F8E8A504	FASTA	504	54,454
	10 20 30 40 50 60 MTQTNGFDAL HAHAQRLRGA AIPALLAAEP ERPTQYARQV GPLYFNFARQ KYDRAALDAL 70 80 90 100 110 120 FAIARERDLS GAFQRLFRGE QVNVTEQRAA LHTALRGDLT DAPVASEAYA TAEEVRQRMG 130 140 150 160 170 180 SLIQQLEATD VTDIVSVGIG GSDLGPRLVA DALRAPSGAR FRVHFVSNVD GAAMQRTLAT 190 200 210 220 230 240 LDPARTAGIL ISKTFGTQET LLNGSILHAW LGGSERLYAV SANPERAAKA FDIAPGRVLP 250 260 270 280 290 300 MWDWVGGRYS LWSAVGFPIA LAIGFERFEQ LLEGAAQFDA HVLNTPLEEN VAVLHGLTAV 310 320 330 340 350 360 WNRNLLGSAT HAVMTYDQRL ALLPAYLQQL VMESLGKRVK LDGSAVDSDT VSVWWGGAGT 370 380 390 400 410 420 DVQHSFFQAL HQGTSVVPAD FIGTVHNDDP YAENHTALMA NVLAQTEALA NGQDSSDPHR 430 440 450 460 470 480 SYPGGRPSTV ILLDALTPQA LGALISMYEH SVYVQSVMWG INAFDQFGVE LGKQLASQLL 490 500 PALKGESVDV ADPVTRELLN KLRG

References

[1]	"Requirement for phosphoglucose isomerase of Xanthomonas campestris in pathogenesis of citrus canker." Tung S.Y., Kuo T.T. Appl. Environ. Microbiol. 65:5564-5570(1999) [PubMed: 10584018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: XW47.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF054807 Genomic DNA. Translation: AAC08426.1. Different initiation.
PIR	T46970.
3D structure databases
ProteinModelPortal	P0A0T1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_XANCI

Accession

Primary (citable) accession number: P0A0T1
Secondary accession number(s): O68824

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	September 21, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program