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Protein

10 kDa chaperonin

Gene

groS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciHPY:HP0011-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
10 kDa chaperonin
Alternative name(s):
GroES protein
Heat shock protein 10
Protein Cpn10
Gene namesi
Name:groS
Synonyms:groES, hsp10, hspA, mopB
Ordered Locus Names:HP_0011
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001747641 – 11810 kDa chaperoninAdd BLAST118

Proteomic databases

PaxDbiP0A0R3.

Interactioni

Subunit structurei

Heptamer of 7 subunits arranged in a ring.By similarity

Protein-protein interaction databases

IntActiP0A0R3. 4 interactors.
MINTiMINT-173683.
STRINGi85962.HP0011.

Structurei

3D structure databases

ProteinModelPortaliP0A0R3.
SMRiP0A0R3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GroES chaperonin family.Curated

Phylogenomic databases

eggNOGiENOG4105K5Y. Bacteria.
COG0234. LUCA.
KOiK04078.
OMAiEHESCCH.

Family and domain databases

CDDicd00320. cpn10. 1 hit.
Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10. 1 hit.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A0R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFQPLGERV LVERLEEENK TSSGIIIPDN AKEKPLMGVV KAVSHKISEG
60 70 80 90 100
CKCVKEGDVI AFGKYKGAEI VLDGTEYMVL ELEDILGIVG SGSCCHTGNH
110
DHKHAKEHEA CCHDHKKH
Length:118
Mass (Da):12,991
Last modified:March 1, 2005 - v1
Checksum:i5A965CD4C2FF014A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti75T → V in strain: 85P. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23798 Genomic DNA. Translation: AAC41440.1.
AE000511 Genomic DNA. Translation: AAD07081.1.
PIRiS61396.
RefSeqiNP_206813.1. NC_000915.1.
WP_000671934.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07081; AAD07081; HP_0011.
GeneIDi899090.
KEGGiheo:C694_00050.
hpy:HP0011.
PATRICi20591215. VBIHelPyl33062_0009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23798 Genomic DNA. Translation: AAC41440.1.
AE000511 Genomic DNA. Translation: AAD07081.1.
PIRiS61396.
RefSeqiNP_206813.1. NC_000915.1.
WP_000671934.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP0A0R3.
SMRiP0A0R3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0A0R3. 4 interactors.
MINTiMINT-173683.
STRINGi85962.HP0011.

Proteomic databases

PaxDbiP0A0R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07081; AAD07081; HP_0011.
GeneIDi899090.
KEGGiheo:C694_00050.
hpy:HP0011.
PATRICi20591215. VBIHelPyl33062_0009.

Phylogenomic databases

eggNOGiENOG4105K5Y. Bacteria.
COG0234. LUCA.
KOiK04078.
OMAiEHESCCH.

Enzyme and pathway databases

BioCyciHPY:HP0011-MONOMER.

Family and domain databases

CDDicd00320. cpn10. 1 hit.
Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10. 1 hit.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH10_HELPY
AccessioniPrimary (citable) accession number: P0A0R3
Secondary accession number(s): P48225
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.