Reviewed, UniProtKB/Swiss-Prot P0A0R3 (CH10_HELPY)

Names and origin

Protein names

Recommended name:
    10 kDa chaperonin
Alternative name(s):
    Protein Cpn10
    groES protein
    Heat shock protein 10

Gene names

Name:	groS
Synonyms:	groES, hsp10, hspA, mopB
Ordered Locus Names:	HP_0011

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. HAMAP MF_00580
Subunit structure	Heptamer of 7 subunits arranged in a ring By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the groES chaperonin family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: HAMAP response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 118	118	10 kDa chaperonin HAMAP MF_00580		PRO_0000174764
Natural variations
	Natural variant	75	1	T → V in strain: 85P.

Sequences

	Sequence		Length	Mass (Da)
	P0A0R3-1 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 5A965CD4C2FF014A	FASTA	118	12,991
	10 20 30 40 50 60 MKFQPLGERV LVERLEEENK TSSGIIIPDN AKEKPLMGVV KAVSHKISEG CKCVKEGDVI 70 80 90 100 110 AFGKYKGAEI VLDGTEYMVL ELEDILGIVG SGSCCHTGNH DHKHAKEHEA CCHDHKKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Helicobacter pylori hspA-hspB heat-shock gene cluster: nucleotide sequence, expression, putative function and immunogenicity." Suerbaum S., Thiberge J.-M., Kansau I., Ferrero R.L., Labigne A. Mol. Microbiol. 14:959-974(1994) [PubMed: 7715457] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 85P.
[2]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L23798 Genomic DNA. Translation: AAC41440.1. AE000511 Genomic DNA. Translation: AAD07081.1.
PIR	S61396.
RefSeq	NP_206813.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	899090.
GenomeReviews	Gene locus HP_0011 in contig AE000511_GR.
KEGG	hpy:HP0011.
TIGR	HP_0011.
Phylogenomic databases
HOGENOM	HBG703377.
OMA	FGQYAGQ.
Family and domain databases
HAMAP	MF_00580. [Tree]
InterPro	IPR020818. Chaperonin_Cpn10. IPR018369. Chaprnonin_Cpn10_CS. IPR001476. Chaprnonin_Cpn10_subgroup. IPR011032. GroES-like. [Graphical view]
Gene3D	G3DSA:2.30.33.40. Chaprnin_Cpn10. 1 hit.
PANTHER	PTHR10772. Chaprnin_Cpn10. 1 hit.
Pfam	PF00166. Cpn10. 1 hit. [Graphical view]
PRINTS	PR00297. CHAPERONIN10.
SMART	SM00883. Cpn10. 1 hit. [Graphical view]
PROSITE	PS00681. CHAPERONINS_CPN10. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CH10_HELPY

Accession

Primary (citable) accession number: P0A0R3
Secondary accession number(s): P48225

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	December 15, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)