P0A0R1 (BFRA_NEIMB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bacterioferritin A
Short name=BFR A
EC=1.16.3.1

Gene names

Name:	bfrA
Ordered Locus Names:	NMB1207

Organism

Neisseria meningitidis serogroup B (strain MC58) [Reference proteome] [HAMAP]

Taxonomic identifier

122586 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria meningitidis › Neisseria meningitidis serogroup B

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex By similarity.
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer Potential. Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center By similarity.
Subunit structure	Oligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited By similarity.
Sequence similarities	Belongs to the bacterioferritin family. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW iron ion transport Inferred from electronic annotation. Source: InterPro
Molecular_function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 154	154	Bacterioferritin A		PRO_0000192604
Regions
	Domain	1 – 145	145	Ferritin-like diiron
Sites
	Metal binding	18	1	Iron 1 By similarity
	Metal binding	48	1	Iron (heme axial ligand); shared with dimeric partner Potential
	Metal binding	51	1	Iron 1 By similarity
	Metal binding	51	1	Iron 2 By similarity
	Metal binding	54	1	Iron 1 By similarity
	Metal binding	93	1	Iron 2 By similarity
	Metal binding	127	1	Iron 1 By similarity
	Metal binding	127	1	Iron 2 By similarity
	Metal binding	130	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A0R1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 15136D10DDA4346A	FASTA	154	17,961
	10 20 30 40 50 60 MQGNQAVVDY MNELLSGELA ARDQYFIHSR LYSEWGYTKL FERLNHEMEE ETTHAEDFIR 70 80 90 100 110 120 RILMLGGTPK MARAELNIGT DVVSCLKADL QTEYEVRDAL KKGIKLCEEA QDYVTRDLMV 130 140 150 AQLKDTEEDH AHWLEQQLRL IELIGEGNYY QSQL

References

[1]

"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58." Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O. , Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. Science 287:1809-1815(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC58.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE002098 Genomic DNA. Translation: AAF41589.1.
PIR	F81110.
RefSeq	NP_274232.1. NC_003112.2.
3D structure databases
ProteinModelPortal	P0A0R1.
ModBase	Search...
Protein-protein interaction databases
STRING	122586.NMB1207.
Proteomic databases
PRIDE	P0A0R1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAF41589; AAF41589; NMB1207.
GeneID	903629.
KEGG	nme:NMB1207.
PATRIC	20358003. VBINeiMen85645_1514.
Phylogenomic databases
eggNOG	COG2193.
HOGENOM	HOG000262383.
KO	K03594.
OMA	MDQYFVH.
ProtClustDB	CLSK877936.
Enzyme and pathway databases
BioCyc	NMEN122586:GHGG-1204-MONOMER.
Family and domain databases
Gene3D	1.20.1260.10. 1 hit.
InterPro	IPR002024. Bacterioferritin. IPR009040. Ferritin-like_diiron. IPR009078. Ferritin-like_SF. IPR012347. Ferritin-rel. IPR008331. Ferritin_DPS_dom. [Graphical view]
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
PIRSF	PIRSF002560. Bacterioferritin. 1 hit.
PRINTS	PR00601. BACFERRITIN.
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMs	TIGR00754. bfr. 1 hit.
PROSITE	PS00549. BACTERIOFERRITIN. 1 hit. PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BFRA_NEIMB

Accession

Primary (citable) accession number: P0A0R1
Secondary accession number(s): P72080

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program