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P0A0Q5

- ACPS_NEIMB

UniProt

P0A0Q5 - ACPS_NEIMB

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Protein
Holo-[acyl-carrier-protein] synthase
Gene
acpS, dpj, NMB0452
Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Magnesium By similarity
Metal bindingi57 – 571Magnesium By similarity

GO - Molecular functioni

  1. holo-[acyl-carrier-protein] synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
  2. macromolecule biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciNMEN122586:GHGG-476-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthase (EC:2.7.8.7)
Short name:
Holo-ACP synthase
Alternative name(s):
4'-phosphopantetheinyl transferase AcpS
Gene namesi
Name:acpS
Synonyms:dpj
Ordered Locus Names:NMB0452
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000425: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125Holo-[acyl-carrier-protein] synthaseUniRule annotation
PRO_0000175677Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi122586.NMB0452.

Structurei

3D structure databases

ProteinModelPortaliP0A0Q5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0736.
HOGENOMiHOG000014316.
KOiK00997.
OMAiYINHALL.
OrthoDBiEOG6384R9.

Family and domain databases

Gene3Di3.90.470.20. 1 hit.
HAMAPiMF_00101. AcpS.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. PPantethiene-prot_Trfase_dom.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56214. SSF56214. 1 hit.
TIGRFAMsiTIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A0Q5-1 [UniParc]FASTAAdd to Basket

« Hide

MIYGIGTDIV SLKRIIRLNK KFGQAFAGRI LTPEELLEFP QAGKPVNYLA    50
KRFAAKEAFA KAVGTGIRGA VSFRNIGIGH DALGKPEFFY GPALSKWLEE 100
QGISRVSLSM SDEEDTVLAF VVAEK 125
Length:125
Mass (Da):13,677
Last modified:February 15, 2005 - v1
Checksum:i64AD823F8529EC6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002098 Genomic DNA. Translation: AAF40889.1.
PIRiF81197.
RefSeqiNP_273499.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF40889; AAF40889; NMB0452.
GeneIDi902568.
KEGGinme:NMB0452.
PATRICi20356118. VBINeiMen85645_0575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002098 Genomic DNA. Translation: AAF40889.1 .
PIRi F81197.
RefSeqi NP_273499.1. NC_003112.2.

3D structure databases

ProteinModelPortali P0A0Q5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 122586.NMB0452.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF40889 ; AAF40889 ; NMB0452 .
GeneIDi 902568.
KEGGi nme:NMB0452.
PATRICi 20356118. VBINeiMen85645_0575.

Phylogenomic databases

eggNOGi COG0736.
HOGENOMi HOG000014316.
KOi K00997.
OMAi YINHALL.
OrthoDBi EOG6384R9.

Enzyme and pathway databases

BioCyci NMEN122586:GHGG-476-MONOMER.

Family and domain databases

Gene3Di 3.90.470.20. 1 hit.
HAMAPi MF_00101. AcpS.
InterProi IPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. PPantethiene-prot_Trfase_dom.
[Graphical view ]
Pfami PF01648. ACPS. 1 hit.
[Graphical view ]
ProDomi PD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56214. SSF56214. 1 hit.
TIGRFAMsi TIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC58.

Entry informationi

Entry nameiACPS_NEIMB
AccessioniPrimary (citable) accession number: P0A0Q5
Secondary accession number(s): Q9RML8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi