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P0A0Q5

- ACPS_NEIMB

UniProt

P0A0Q5 - ACPS_NEIMB

Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

    Catalytic activityi

    CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81MagnesiumUniRule annotation
    Metal bindingi57 – 571MagnesiumUniRule annotation

    GO - Molecular functioni

    1. holo-[acyl-carrier-protein] synthase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
    2. macromolecule biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciNMEN122586:GHGG-476-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
    Short name:
    Holo-ACP synthaseUniRule annotation
    Alternative name(s):
    4'-phosphopantetheinyl transferase AcpSUniRule annotation
    Gene namesi
    Name:acpSUniRule annotation
    Synonyms:dpj
    Ordered Locus Names:NMB0452
    OrganismiNeisseria meningitidis serogroup B (strain MC58)
    Taxonomic identifieri122586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000000425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 125125Holo-[acyl-carrier-protein] synthasePRO_0000175677Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi122586.NMB0452.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A0Q5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0736.
    HOGENOMiHOG000014316.
    KOiK00997.
    OMAiYINHALL.
    OrthoDBiEOG6384R9.

    Family and domain databases

    Gene3Di3.90.470.20. 1 hit.
    HAMAPiMF_00101. AcpS.
    InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
    IPR002582. ACPS.
    IPR004568. PPantethiene-prot_Trfase_dom.
    [Graphical view]
    PfamiPF01648. ACPS. 1 hit.
    [Graphical view]
    ProDomiPD004282. PPantethiene-prot_Trfase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56214. SSF56214. 1 hit.
    TIGRFAMsiTIGR00516. acpS. 1 hit.
    TIGR00556. pantethn_trn. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A0Q5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIYGIGTDIV SLKRIIRLNK KFGQAFAGRI LTPEELLEFP QAGKPVNYLA    50
    KRFAAKEAFA KAVGTGIRGA VSFRNIGIGH DALGKPEFFY GPALSKWLEE 100
    QGISRVSLSM SDEEDTVLAF VVAEK 125
    Length:125
    Mass (Da):13,677
    Last modified:February 15, 2005 - v1
    Checksum:i64AD823F8529EC6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002098 Genomic DNA. Translation: AAF40889.1.
    PIRiF81197.
    RefSeqiNP_273499.1. NC_003112.2.

    Genome annotation databases

    EnsemblBacteriaiAAF40889; AAF40889; NMB0452.
    GeneIDi902568.
    KEGGinme:NMB0452.
    PATRICi20356118. VBINeiMen85645_0575.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002098 Genomic DNA. Translation: AAF40889.1 .
    PIRi F81197.
    RefSeqi NP_273499.1. NC_003112.2.

    3D structure databases

    ProteinModelPortali P0A0Q5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 122586.NMB0452.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF40889 ; AAF40889 ; NMB0452 .
    GeneIDi 902568.
    KEGGi nme:NMB0452.
    PATRICi 20356118. VBINeiMen85645_0575.

    Phylogenomic databases

    eggNOGi COG0736.
    HOGENOMi HOG000014316.
    KOi K00997.
    OMAi YINHALL.
    OrthoDBi EOG6384R9.

    Enzyme and pathway databases

    BioCyci NMEN122586:GHGG-476-MONOMER.

    Family and domain databases

    Gene3Di 3.90.470.20. 1 hit.
    HAMAPi MF_00101. AcpS.
    InterProi IPR008278. 4-PPantetheinyl_Trfase_SF.
    IPR002582. ACPS.
    IPR004568. PPantethiene-prot_Trfase_dom.
    [Graphical view ]
    Pfami PF01648. ACPS. 1 hit.
    [Graphical view ]
    ProDomi PD004282. PPantethiene-prot_Trfase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56214. SSF56214. 1 hit.
    TIGRFAMsi TIGR00516. acpS. 1 hit.
    TIGR00556. pantethn_trn. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC58.

    Entry informationi

    Entry nameiACPS_NEIMB
    AccessioniPrimary (citable) accession number: P0A0Q5
    Secondary accession number(s): Q9RML8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3