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Protein

HTH-type transcriptional regulator QacR

Gene

qacR

Organism
Staphylococcus haemolyticus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi24 – 4320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator QacR
Gene namesi
Name:qacR
Encoded oniPlasmid pNVH97A1 Publication
OrganismiStaphylococcus haemolyticus
Taxonomic identifieri1283 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188HTH-type transcriptional regulator QacRPRO_0000070610Add
BLAST

Interactioni

Subunit structurei

Homodimer. Binds cooperatively to DNA as a pair of dimers (By similarity).By similarity

Structurei

Secondary structure

1
188
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1714Combined sources
Turni20 – 223Combined sources
Helixi25 – 306Combined sources
Turni31 – 333Combined sources
Helixi36 – 383Combined sources
Turni41 – 433Combined sources
Helixi46 – 6621Combined sources
Helixi69 – 713Combined sources
Helixi75 – 8814Combined sources
Beta strandi90 – 923Combined sources
Helixi93 – 953Combined sources
Helixi96 – 10510Combined sources
Turni110 – 1178Combined sources
Helixi118 – 13619Combined sources
Helixi145 – 16117Combined sources
Helixi168 – 18619Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G0EX-ray2.88A/B/D/E1-188[»]
ProteinModelPortaliP0A0N5.
SMRiP0A0N5. Positions 2-187.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0N5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6161HTH tetR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR013571. Tscrpt_reg_QacR_C.
[Graphical view]
PfamiPF08360. TetR_C_5. 1 hit.
PF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A0N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLKDKILGV AKELFIKNGY NATTTGEIVK LSESSKGNLY YHFKTKENLF
60 70 80 90 100
LEILNIEESK WQEQWKKEQI KCKTNREKFY LYNELSLTTE YYYPLQNAII
110 120 130 140 150
EFYTEYYKTN SINEKMNKLE NKYIDAYHVI FKEGNLNGEW CINDVNAVSK
160 170 180
IAANAVNGIV TFTHEQNINE RIKLMNKFSQ IFLNGLSK
Length:188
Mass (Da):22,174
Last modified:March 1, 2005 - v1
Checksum:i7B91E005C8D47322
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400722 Genomic DNA. Translation: CAB94807.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400722 Genomic DNA. Translation: CAB94807.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G0EX-ray2.88A/B/D/E1-188[»]
ProteinModelPortaliP0A0N5.
SMRiP0A0N5. Positions 2-187.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0N5.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 1 hit.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR013571. Tscrpt_reg_QacR_C.
[Graphical view]
PfamiPF08360. TetR_C_5. 1 hit.
PF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Organization of the antiseptic resistance gene qacA and Tn552-related beta-lactamase genes in multidrug-resistant Staphylococcus haemolyticus strains of animal and human origins."
    Anthonisen I.-L., Sunde M., Steinum T.M., Sidhu M.S., Sorum H.
    Antimicrob. Agents Chemother. 46:3606-3612(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NVH97A.
    Plasmid: pNVH97A

Entry informationi

Entry nameiQACR_STAHA
AccessioniPrimary (citable) accession number: P0A0N5
Secondary accession number(s): P23217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: March 16, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.