SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0A0M5

- TYSY_STAAU

UniProt

P0A0M5 - TYSY_STAAU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Thymidylate synthase
Gene
thyA, thyE, thyF
Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei201 – 2011 By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:thyA
Synonyms:thyE, thyF
Encoded oniPlasmid pSK11 Publication
Plasmid pABU11 Publication
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Thymidylate synthaseUniRule annotation
PRO_0000141022Add
BLAST

Proteomic databases

PRIDEiP0A0M5.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP0A0M5.
SMRiP0A0M5. Positions 5-318.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.572.10. 2 hits.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A0M5-1 [UniParc]FASTAAdd to Basket

« Hide

MYNPFDEAYH GLCEEILEIG NRRDDRTHTG TISKFGHQLR FDLTKGFPLL    50
TTKKVSFKLV ATELLWFIKG DTNIQYLLKY NNNIWNEWAF ENYVQSDDYH 100
GPDMTDFGHR SQQDPEFNEQ YKEEMKKFKE RILNDDAFAK KYGNLGNVYG 150
KQWRDWEDKN GNHYDQLKSV IQQIKTNPNS RRHIVSAWNP TEIDSMALPP 200
CHTMFQFYVQ EGKLNCQLYQ RSADIFLGVP FNIASYALLT HLVAKECGLE 250
VGEFIHTFGD AHIYSNHMDA IHTQLSRDSY LPPQLKINTD KSIFDINYED 300
LELINYESHP AIKAPIAV 318
Length:318
Mass (Da):37,178
Last modified:February 15, 2005 - v1
Checksum:i4CE480445CF9653A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13290 Genomic DNA. Translation: CAA31648.1.
Y07536 Genomic DNA. Translation: CAA68823.1.
PIRiS04163. YXSAT3.
RefSeqiNP_877984.1. NC_005054.1.
YP_002790944.1. NC_012547.1.
YP_003813114.1. NC_014369.1.
YP_006937651.1. NC_013320.1.
YP_006938353.1. NC_013338.1.

Genome annotation databases

GeneIDi13874801.
13875494.
2598377.
7751509.
9487079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13290 Genomic DNA. Translation: CAA31648.1 .
Y07536 Genomic DNA. Translation: CAA68823.1 .
PIRi S04163. YXSAT3.
RefSeqi NP_877984.1. NC_005054.1.
YP_002790944.1. NC_012547.1.
YP_003813114.1. NC_014369.1.
YP_006937651.1. NC_013320.1.
YP_006938353.1. NC_013338.1.

3D structure databases

ProteinModelPortali P0A0M5.
SMRi P0A0M5. Positions 5-318.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P0A0M5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 13874801.
13875494.
2598377.
7751509.
9487079.

Enzyme and pathway databases

UniPathwayi UPA00575 .

Family and domain databases

Gene3Di 3.30.572.10. 2 hits.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Trimethoprim resistance transposon Tn4003 from Staphylococcus aureus encodes genes for a dihydrofolate reductase and thymidylate synthetase flanked by three copies of IS257."
    Rouch D.A., Messeroti L.J., Loo L.S.L., Jackson C.A., Skurray R.A.
    Mol. Microbiol. 3:161-175(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Transposon: Tn4003.
    Plasmid: pSK1
  2. "Identical genes for trimethoprim-resistant dihydrofolate reductase from Staphylococcus aureus in Australia and central Europe."
    Burdeska A., Ott M., Bannwarth W., Then R.L.
    FEBS Lett. 266:159-162(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 157/4696.
    Plasmid: pABU1

Entry informationi

Entry nameiTYSY_STAAU
AccessioniPrimary (citable) accession number: P0A0M5
Secondary accession number(s): P13954, Q59907
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi