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P0A0M0

- ETXH_STAAU

UniProt

P0A0M0 - ETXH_STAAU

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Protein
Enterotoxin type H
Gene
entH, seh
Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Cofactori

Binds 1 zinc ion per subunit. The zinc ion is necessary for the toxin interaction with MHC class II.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi230 – 2301Zinc
Metal bindingi232 – 2321Zinc

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type H
Alternative name(s):
SEH
Gene namesi
Name:entH
Synonyms:seh
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424
Add
BLAST
Chaini25 – 241217Enterotoxin type H
PRO_0000035617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi106 ↔ 116

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 323
Helixi35 – 4612
Beta strandi49 – 568
Turni61 – 633
Beta strandi64 – 674
Helixi72 – 743
Beta strandi76 – 805
Helixi84 – 907
Beta strandi93 – 997
Beta strandi110 – 1123
Beta strandi114 – 1196
Beta strandi121 – 1233
Beta strandi127 – 14014
Beta strandi148 – 15811
Helixi159 – 17416
Beta strandi178 – 1825
Beta strandi185 – 19511
Beta strandi197 – 2015
Beta strandi206 – 2094
Helixi210 – 2134
Helixi214 – 2174
Beta strandi222 – 2243
Helixi225 – 2273
Beta strandi228 – 2369

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ENFX-ray1.69A26-237[»]
1EWCX-ray1.95A26-239[»]
1F77X-ray2.40A/B25-241[»]
1HXYX-ray2.60D25-237[»]
2XN9X-ray2.30C25-241[»]
2XNAX-ray2.10C25-241[»]
ProteinModelPortaliP0A0M0.
SMRiP0A0M0. Positions 26-237.

Miscellaneous databases

EvolutionaryTraceiP0A0M0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A0M0-1 [UniParc]FASTAAdd to Basket

« Hide

MINKIKILFS FLALLLSFTS YAKAEDLHDK SELTDLALAN AYGQYNHPFI    50
KENIKSDEIS GEKDLIFRNQ GDSGNDLRVK FATADLAQKF KNKNVDIYGA 100
SFYYKCEKIS ENISECLYGG TTLNSEKLAQ ERVIGANVWV DGIQKETELI 150
RTNKKNVTLQ ELDIKIRKIL SDKYKIYYKD SEISKGLIEF DMKTPRDYSF 200
DIYDLKGEND YEIDKIYEDN KTLKSDDISH IDVNLYTKKK V 241
Length:241
Mass (Da):27,859
Last modified:February 15, 2005 - v1
Checksum:i70F77985877616CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11702 Genomic DNA. Translation: AAA19777.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11702 Genomic DNA. Translation: AAA19777.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ENF X-ray 1.69 A 26-237 [» ]
1EWC X-ray 1.95 A 26-239 [» ]
1F77 X-ray 2.40 A/B 25-241 [» ]
1HXY X-ray 2.60 D 25-237 [» ]
2XN9 X-ray 2.30 C 25-241 [» ]
2XNA X-ray 2.10 C 25-241 [» ]
ProteinModelPortali P0A0M0.
SMRi P0A0M0. Positions 26-237.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P0A0M0.

Family and domain databases

Gene3Di 3.10.20.120. 1 hit.
InterProi IPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view ]
Pfami PF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view ]
PRINTSi PR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMi SSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEi PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization and biological properties of a new staphylococcal exotoxin."
    Ren K., Bannan J.D., Pancholi V., Cheung A.L., Robbins J.C., Fischetti V.A., Zabriskie J.B.
    J. Exp. Med. 180:1675-1683(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    Strain: D4508.
  2. "The crystal structure of staphylococcal enterotoxin H: implications for binding properties to MHC class II and TcR molecules."
    Haekansson M., Petersson K., Nilsson H., Forsberg G., Bjoerk P., Antonsson P., Svensson L.A.
    J. Mol. Biol. 302:527-537(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS).

Entry informationi

Entry nameiETXH_STAAU
AccessioniPrimary (citable) accession number: P0A0M0
Secondary accession number(s): Q53585
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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