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Protein

Enterotoxin type H

Gene

entH

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit. The zinc ion is necessary for the toxin interaction with MHC class II.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi230Zinc1
Metal bindingi232Zinc1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type H
Alternative name(s):
SEH
Gene namesi
Name:entH
Synonyms:seh
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000003561725 – 241Enterotoxin type HAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi106 ↔ 116

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 32Combined sources3
Helixi35 – 46Combined sources12
Beta strandi49 – 56Combined sources8
Turni61 – 63Combined sources3
Beta strandi64 – 67Combined sources4
Helixi72 – 74Combined sources3
Beta strandi76 – 80Combined sources5
Helixi84 – 90Combined sources7
Beta strandi93 – 99Combined sources7
Beta strandi110 – 112Combined sources3
Beta strandi114 – 119Combined sources6
Beta strandi121 – 123Combined sources3
Beta strandi127 – 140Combined sources14
Beta strandi148 – 158Combined sources11
Helixi159 – 174Combined sources16
Beta strandi178 – 182Combined sources5
Beta strandi185 – 195Combined sources11
Beta strandi197 – 201Combined sources5
Beta strandi206 – 209Combined sources4
Helixi210 – 213Combined sources4
Helixi214 – 217Combined sources4
Beta strandi222 – 224Combined sources3
Helixi225 – 227Combined sources3
Beta strandi228 – 236Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ENFX-ray1.69A26-237[»]
1EWCX-ray1.95A26-239[»]
1F77X-ray2.40A/B25-241[»]
1HXYX-ray2.60D25-237[»]
2XN9X-ray2.30C25-241[»]
2XNAX-ray2.10C25-241[»]
ProteinModelPortaliP0A0M0.
SMRiP0A0M0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0M0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A0M0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINKIKILFS FLALLLSFTS YAKAEDLHDK SELTDLALAN AYGQYNHPFI
60 70 80 90 100
KENIKSDEIS GEKDLIFRNQ GDSGNDLRVK FATADLAQKF KNKNVDIYGA
110 120 130 140 150
SFYYKCEKIS ENISECLYGG TTLNSEKLAQ ERVIGANVWV DGIQKETELI
160 170 180 190 200
RTNKKNVTLQ ELDIKIRKIL SDKYKIYYKD SEISKGLIEF DMKTPRDYSF
210 220 230 240
DIYDLKGEND YEIDKIYEDN KTLKSDDISH IDVNLYTKKK V
Length:241
Mass (Da):27,859
Last modified:February 15, 2005 - v1
Checksum:i70F77985877616CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11702 Genomic DNA. Translation: AAA19777.1.
RefSeqiWP_000608674.1. NZ_MAQO01000020.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11702 Genomic DNA. Translation: AAA19777.1.
RefSeqiWP_000608674.1. NZ_MAQO01000020.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ENFX-ray1.69A26-237[»]
1EWCX-ray1.95A26-239[»]
1F77X-ray2.40A/B25-241[»]
1HXYX-ray2.60D25-237[»]
2XN9X-ray2.30C25-241[»]
2XNAX-ray2.10C25-241[»]
ProteinModelPortaliP0A0M0.
SMRiP0A0M0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0M0.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETXH_STAAU
AccessioniPrimary (citable) accession number: P0A0M0
Secondary accession number(s): Q53585
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.