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P0A0M0

- ETXH_STAAU

UniProt

P0A0M0 - ETXH_STAAU

Protein

Enterotoxin type H

Gene

entH

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

    Cofactori

    Binds 1 zinc ion per subunit. The zinc ion is necessary for the toxin interaction with MHC class II.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi230 – 2301Zinc
    Metal bindingi232 – 2321Zinc

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Enterotoxin, Superantigen, Toxin

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enterotoxin type H
    Alternative name(s):
    SEH
    Gene namesi
    Name:entH
    Synonyms:seh
    OrganismiStaphylococcus aureus
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 241217Enterotoxin type HPRO_0000035617Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi106 ↔ 116

    Keywords - PTMi

    Disulfide bond

    Structurei

    Secondary structure

    1
    241
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi30 – 323
    Helixi35 – 4612
    Beta strandi49 – 568
    Turni61 – 633
    Beta strandi64 – 674
    Helixi72 – 743
    Beta strandi76 – 805
    Helixi84 – 907
    Beta strandi93 – 997
    Beta strandi110 – 1123
    Beta strandi114 – 1196
    Beta strandi121 – 1233
    Beta strandi127 – 14014
    Beta strandi148 – 15811
    Helixi159 – 17416
    Beta strandi178 – 1825
    Beta strandi185 – 19511
    Beta strandi197 – 2015
    Beta strandi206 – 2094
    Helixi210 – 2134
    Helixi214 – 2174
    Beta strandi222 – 2243
    Helixi225 – 2273
    Beta strandi228 – 2369

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ENFX-ray1.69A26-237[»]
    1EWCX-ray1.95A26-239[»]
    1F77X-ray2.40A/B25-241[»]
    1HXYX-ray2.60D25-237[»]
    2XN9X-ray2.30C25-241[»]
    2XNAX-ray2.10C25-241[»]
    ProteinModelPortaliP0A0M0.
    SMRiP0A0M0. Positions 26-237.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0A0M0.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.10.20.120. 1 hit.
    InterProiIPR008992. Enterotoxin.
    IPR006126. Staph/Strept_toxin_CS.
    IPR006173. Staph_tox_OB.
    IPR016091. SuperAg_toxin_C.
    IPR013307. Superantigen_bac.
    IPR006123. Toxin_b-grasp_Staph/Strep.
    IPR006177. Toxin_bac.
    [Graphical view]
    PfamiPF02876. Stap_Strp_tox_C. 1 hit.
    PF01123. Stap_Strp_toxin. 1 hit.
    [Graphical view]
    PRINTSiPR00279. BACTRLTOXIN.
    PR01898. SAGSUPRFAMLY.
    SUPFAMiSSF50203. SSF50203. 1 hit.
    SSF54334. SSF54334. 1 hit.
    PROSITEiPS00278. STAPH_STREP_TOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0A0M0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINKIKILFS FLALLLSFTS YAKAEDLHDK SELTDLALAN AYGQYNHPFI    50
    KENIKSDEIS GEKDLIFRNQ GDSGNDLRVK FATADLAQKF KNKNVDIYGA 100
    SFYYKCEKIS ENISECLYGG TTLNSEKLAQ ERVIGANVWV DGIQKETELI 150
    RTNKKNVTLQ ELDIKIRKIL SDKYKIYYKD SEISKGLIEF DMKTPRDYSF 200
    DIYDLKGEND YEIDKIYEDN KTLKSDDISH IDVNLYTKKK V 241
    Length:241
    Mass (Da):27,859
    Last modified:February 15, 2005 - v1
    Checksum:i70F77985877616CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11702 Genomic DNA. Translation: AAA19777.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11702 Genomic DNA. Translation: AAA19777.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ENF X-ray 1.69 A 26-237 [» ]
    1EWC X-ray 1.95 A 26-239 [» ]
    1F77 X-ray 2.40 A/B 25-241 [» ]
    1HXY X-ray 2.60 D 25-237 [» ]
    2XN9 X-ray 2.30 C 25-241 [» ]
    2XNA X-ray 2.10 C 25-241 [» ]
    ProteinModelPortali P0A0M0.
    SMRi P0A0M0. Positions 26-237.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P0A0M0.

    Family and domain databases

    Gene3Di 3.10.20.120. 1 hit.
    InterProi IPR008992. Enterotoxin.
    IPR006126. Staph/Strept_toxin_CS.
    IPR006173. Staph_tox_OB.
    IPR016091. SuperAg_toxin_C.
    IPR013307. Superantigen_bac.
    IPR006123. Toxin_b-grasp_Staph/Strep.
    IPR006177. Toxin_bac.
    [Graphical view ]
    Pfami PF02876. Stap_Strp_tox_C. 1 hit.
    PF01123. Stap_Strp_toxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00279. BACTRLTOXIN.
    PR01898. SAGSUPRFAMLY.
    SUPFAMi SSF50203. SSF50203. 1 hit.
    SSF54334. SSF54334. 1 hit.
    PROSITEi PS00278. STAPH_STREP_TOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and biological properties of a new staphylococcal exotoxin."
      Ren K., Bannan J.D., Pancholi V., Cheung A.L., Robbins J.C., Fischetti V.A., Zabriskie J.B.
      J. Exp. Med. 180:1675-1683(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
      Strain: D4508.
    2. "The crystal structure of staphylococcal enterotoxin H: implications for binding properties to MHC class II and TcR molecules."
      Haekansson M., Petersson K., Nilsson H., Forsberg G., Bjoerk P., Antonsson P., Svensson L.A.
      J. Mol. Biol. 302:527-537(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS).

    Entry informationi

    Entry nameiETXH_STAAU
    AccessioniPrimary (citable) accession number: P0A0M0
    Secondary accession number(s): Q53585
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3