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P0A0M0 (ETXH_STAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enterotoxin type H
Alternative name(s):
SEH
Gene names
Name:entH
Synonyms:seh
OrganismStaphylococcus aureus
Taxonomic identifier1280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Cofactor

Binds 1 zinc ion per subunit. The zinc ion is necessary for the toxin interaction with MHC class II.

Subcellular location

Secreted.

Sequence similarities

Belongs to the staphylococcal/streptococcal toxin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandMetal-binding
Zinc
   Molecular functionEnterotoxin
Superantigen
Toxin
   PTMDisulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 241217Enterotoxin type H
PRO_0000035617

Sites

Metal binding2301Zinc
Metal binding2321Zinc

Amino acid modifications

Disulfide bond106 ↔ 116

Secondary structure

........................................... 241
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A0M0 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 70F77985877616CE

FASTA24127,859
        10         20         30         40         50         60 
MINKIKILFS FLALLLSFTS YAKAEDLHDK SELTDLALAN AYGQYNHPFI KENIKSDEIS 

        70         80         90        100        110        120 
GEKDLIFRNQ GDSGNDLRVK FATADLAQKF KNKNVDIYGA SFYYKCEKIS ENISECLYGG 

       130        140        150        160        170        180 
TTLNSEKLAQ ERVIGANVWV DGIQKETELI RTNKKNVTLQ ELDIKIRKIL SDKYKIYYKD 

       190        200        210        220        230        240 
SEISKGLIEF DMKTPRDYSF DIYDLKGEND YEIDKIYEDN KTLKSDDISH IDVNLYTKKK 


V 

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References

[1]"Characterization and biological properties of a new staphylococcal exotoxin."
Ren K., Bannan J.D., Pancholi V., Cheung A.L., Robbins J.C., Fischetti V.A., Zabriskie J.B.
J. Exp. Med. 180:1675-1683(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
Strain: D4508.
[2]"The crystal structure of staphylococcal enterotoxin H: implications for binding properties to MHC class II and TcR molecules."
Haekansson M., Petersson K., Nilsson H., Forsberg G., Bjoerk P., Antonsson P., Svensson L.A.
J. Mol. Biol. 302:527-537(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U11702 Genomic DNA. Translation: AAA19777.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ENFX-ray1.69A26-237[»]
1EWCX-ray1.95A26-239[»]
1F77X-ray2.40A/B25-241[»]
1HXYX-ray2.60D25-237[»]
2XN9X-ray2.30C25-241[»]
2XNAX-ray2.10C25-241[»]
ProteinModelPortalP0A0M0.
SMRP0A0M0. Positions 26-237.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.10.20.120. 1 hit.
InterProIPR008992. Enterotoxin_bac.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEPS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0A0M0.

Entry information

Entry nameETXH_STAAU
AccessionPrimary (citable) accession number: P0A0M0
Secondary accession number(s): Q53585
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references