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Protein

Enterotoxin type H

Gene

entH

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit. The zinc ion is necessary for the toxin interaction with MHC class II.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi230 – 2301ZincBy similarity
Metal bindingi232 – 2321ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-53-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type H
Alternative name(s):
SEH
Gene namesi
Name:entH
Synonyms:seh
Ordered Locus Names:MW0051
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 241217Enterotoxin type HPRO_0000035618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi106 ↔ 116By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP0A0L9.
SMRiP0A0L9. Positions 26-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000112408.
OMAiCLINNKY.
OrthoDBiEOG6MPWSV.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A0L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINKIKILFS FLALLLSFTS YAKAEDLHDK SELTDLALAN AYGQYNHPFI
60 70 80 90 100
KENIKSDEIS GEKDLIFRNQ GDSGNDLRVK FATADLAQKF KNKNVDIYGA
110 120 130 140 150
SFYYKCEKIS ENISECLYGG TTLNSEKLAQ ERVIGANVWV DGIQKETELI
160 170 180 190 200
RTNKKNVTLQ ELDIKIRKIL SDKYKIYYKD SEISKGLIEF DMKTPRDYSF
210 220 230 240
DIYDLKGEND YEIDKIYEDN KTLKSDDISH IDVNLYTKKK V
Length:241
Mass (Da):27,859
Last modified:February 15, 2005 - v1
Checksum:i70F77985877616CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB93916.1.
RefSeqiWP_000608674.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB93916; BAB93916; BAB93916.
PATRICi19566542. VBIStaAur44266_0053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB93916.1.
RefSeqiWP_000608674.1. NC_003923.1.

3D structure databases

ProteinModelPortaliP0A0L9.
SMRiP0A0L9. Positions 26-237.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB93916; BAB93916; BAB93916.
PATRICi19566542. VBIStaAur44266_0053.

Phylogenomic databases

HOGENOMiHOG000112408.
OMAiCLINNKY.
OrthoDBiEOG6MPWSV.

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-53-MONOMER.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiETXH_STAAW
AccessioniPrimary (citable) accession number: P0A0L9
Secondary accession number(s): Q53585
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: March 16, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.