P0A0L5 (ENTC3_STAAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Enterotoxin type C-3

Alternative name(s):
SEC3

Gene names

Name:

entC3

Organism

Staphylococcus aureus

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
Subcellular location	Secreted.
Sequence similarities	Belongs to the staphylococcal/streptococcal toxin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Enterotoxin Superantigen Toxin
PTM	Disulfide bond
Technical term	3D-structure
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 27

27

Chain

28 – 266

239

Enterotoxin type C-3

PRO_0000035611

Amino acid modifications

Disulfide bond

120 ↔ 137

Secondary structure

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266

Helix Strand Turn

Details...

Helix

35 – 37

3

Helix

41 – 43

3

Helix

49 – 52

4

Turn

53 – 55

3

Beta strand

60 – 65

6

Beta strand

69 – 72

4

Beta strand

75 – 78

4

Beta strand

83 – 94

12

Helix

98 – 104

7

Beta strand

109 – 113

5

Beta strand

122 – 124

3

Beta strand

134 – 139

6

Beta strand

142 – 144

3

Turn

146 – 148

3

Turn

151 – 153

3

Beta strand

156 – 164

9

Beta strand

167 – 182

16

Helix

183 – 198

16

Beta strand

200 – 202

3

Beta strand

207 – 216

10

Turn

218 – 220

3

Beta strand

222 – 226

5

Beta strand

231 – 233

3

Helix

237 – 241

5

Helix

242 – 246

5

Beta strand

249 – 251

3

Turn

252 – 254

3

Beta strand

256 – 263

8

Sequences

	Sequence		Length	Mass (Da)
	P0A0L5 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 5ED8A32D11FFCA59	FASTA	266	30,671
	10 20 30 40 50 60 MYKRLFISRV ILIFALILVI STPNVLAESQ PDPMPDDLHK SSEFTGTMGN MKYLYDDHYV 70 80 90 100 110 120 SATKVKSVDK FLAHDLIYNI SDKKLKNYDK VKTELLNEDL AKKYKDEVVD VYGSNYYVNC 130 140 150 160 170 180 YFSSKDNVGK VTGGKTCMYG GITKHEGNHF DNGNLQNVLV RVYENKRNTI SFEVQTDKKS 190 200 210 220 230 240 VTAQELDIKA RNFLINKKNL YEFNSSPYET GYIKFIENNG NTFWYDMMPA PGDKFDQSKY 250 260 LMMYNDNKTV DSKSVKIEVH LTTKNG

References

[1]	"Nucleotide sequence of the staphylococcal enterotoxin C3 gene: sequence comparison of all three type C staphylococcal enterotoxins." Hovde C.J., Hackett S.P., Bohach G.A. Mol. Gen. Genet. 220:329-333(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Crystal structure of a T-cell receptor beta-chain complexed with a superantigen." Fields B.A., Malchiodi E.L., Li H., Ysern X., Stauffacher C.V., Schlievert P.M., Karjalainen K., Mariuzza R.A. Nature 384:188-192(1996) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF COMPLEX WITH TCR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X51661 Genomic DNA. Translation: CAA35972.1.

PIR

S11885.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JCK	X-ray	3.50	B/D	28-266	[»]
1JWM	X-ray	2.70	D	28-266	[»]
1JWS	X-ray	2.60	D	28-266	[»]
1JWU	X-ray	2.30	D	28-266	[»]
1KLG	X-ray	2.40	D	28-266	[»]
1KLU	X-ray	1.93	D	28-266	[»]
1SJE	X-ray	2.45	D	28-266	[»]
1SJH	X-ray	2.25	D	28-266	[»]
1T5X	X-ray	2.50	D	28-266	[»]
2AQ1	X-ray	2.10	B/D/F/H	28-266	[»]
2AQ2	X-ray	1.80	B	28-266	[»]
2AQ3	X-ray	2.30	B/D/F/H	28-266	[»]
2IPK	X-ray	2.30	D	28-266	[»]
3BVG	X-ray	2.00	A	28-266	[»]
3BVM	X-ray	2.00	A	28-266	[»]
3BVZ	X-ray	2.30	A	28-266	[»]
3BYT	X-ray	2.30	B/D/F/H	28-266	[»]
3BYY	X-ray	2.20	B	28-266	[»]
3BZD	X-ray	2.30	B	28-266	[»]

ProteinModelPortal

P0A0L5.

SMR

P0A0L5. Positions 28-266.

ModBase

Search...

Protein family/group databases

Allergome

2141. Sta a SEC.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

3.10.20.120. 1 hit.

InterPro

IPR008992. Enterotoxin_bac.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]

Pfam

PF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]

PRINTS

PR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.

SUPFAM

SSF50203. Bact_endotox. 1 hit.
SSF54334. Stap/Strep_toxin. 1 hit.

PROSITE

PS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P0A0L5.

Entry information

Entry name

ENTC3_STAAU

Accession

Primary (citable) accession number: P0A0L5
Secondary accession number(s): P23313

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program