Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0A0L5 (ENTC3_STAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enterotoxin type C-3
Alternative name(s):
SEC3
Gene names
Name:entC3
OrganismStaphylococcus aureus
Taxonomic identifier1280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Subcellular location

Secreted.

Sequence similarities

Belongs to the staphylococcal/streptococcal toxin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionEnterotoxin
Superantigen
Toxin
   PTMDisulfide bond
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727
Chain28 – 266239Enterotoxin type C-3
PRO_0000035611

Amino acid modifications

Disulfide bond120 ↔ 137

Secondary structure

..................................................... 266
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A0L5 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 5ED8A32D11FFCA59

FASTA26630,671
        10         20         30         40         50         60 
MYKRLFISRV ILIFALILVI STPNVLAESQ PDPMPDDLHK SSEFTGTMGN MKYLYDDHYV 

        70         80         90        100        110        120 
SATKVKSVDK FLAHDLIYNI SDKKLKNYDK VKTELLNEDL AKKYKDEVVD VYGSNYYVNC 

       130        140        150        160        170        180 
YFSSKDNVGK VTGGKTCMYG GITKHEGNHF DNGNLQNVLV RVYENKRNTI SFEVQTDKKS 

       190        200        210        220        230        240 
VTAQELDIKA RNFLINKKNL YEFNSSPYET GYIKFIENNG NTFWYDMMPA PGDKFDQSKY 

       250        260 
LMMYNDNKTV DSKSVKIEVH LTTKNG 

« Hide

References

[1]"Nucleotide sequence of the staphylococcal enterotoxin C3 gene: sequence comparison of all three type C staphylococcal enterotoxins."
Hovde C.J., Hackett S.P., Bohach G.A.
Mol. Gen. Genet. 220:329-333(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Crystal structure of a T-cell receptor beta-chain complexed with a superantigen."
Fields B.A., Malchiodi E.L., Li H., Ysern X., Stauffacher C.V., Schlievert P.M., Karjalainen K., Mariuzza R.A.
Nature 384:188-192(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF COMPLEX WITH TCR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X51661 Genomic DNA. Translation: CAA35972.1.
PIRS11885.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JCKX-ray3.50B/D28-266[»]
1JWMX-ray2.70D28-266[»]
1JWSX-ray2.60D28-266[»]
1JWUX-ray2.30D28-266[»]
1KLGX-ray2.40D28-266[»]
1KLUX-ray1.93D28-266[»]
1SJEX-ray2.45D28-266[»]
1SJHX-ray2.25D28-266[»]
1T5XX-ray2.50D28-266[»]
2AQ1X-ray2.10B/D/F/H28-266[»]
2AQ2X-ray1.80B28-266[»]
2AQ3X-ray2.30B/D/F/H28-266[»]
2IPKX-ray2.30D28-266[»]
3BVGX-ray2.00A28-266[»]
3BVMX-ray2.00A28-266[»]
3BVZX-ray2.30A28-266[»]
3BYTX-ray2.30B/D/F/H28-266[»]
3BYYX-ray2.20B28-266[»]
3BZDX-ray2.30B28-266[»]
ProteinModelPortalP0A0L5.
SMRP0A0L5. Positions 28-266.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome2141. Sta a SEC.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.10.20.120. 1 hit.
InterProIPR008992. Enterotoxin_bac.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0A0L5.
PROP0A0L5.

Entry information

Entry nameENTC3_STAAU
AccessionPrimary (citable) accession number: P0A0L5
Secondary accession number(s): P23313
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: March 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references