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Protein

Enterotoxin type C-3

Gene

entC3

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type C-3
Alternative name(s):
SEC3
Gene namesi
Name:entC3
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2141. Sta a SEC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Add BLAST27
ChainiPRO_000003561128 – 266Enterotoxin type C-3Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi120 ↔ 137

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0A0L5.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2009.

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 37Combined sources3
Helixi41 – 43Combined sources3
Helixi49 – 52Combined sources4
Turni53 – 55Combined sources3
Beta strandi60 – 65Combined sources6
Beta strandi69 – 72Combined sources4
Beta strandi75 – 78Combined sources4
Beta strandi83 – 94Combined sources12
Helixi98 – 104Combined sources7
Beta strandi109 – 113Combined sources5
Beta strandi122 – 124Combined sources3
Beta strandi134 – 139Combined sources6
Beta strandi142 – 144Combined sources3
Turni146 – 148Combined sources3
Turni151 – 153Combined sources3
Beta strandi156 – 164Combined sources9
Beta strandi167 – 182Combined sources16
Helixi183 – 198Combined sources16
Beta strandi200 – 202Combined sources3
Beta strandi207 – 216Combined sources10
Turni218 – 220Combined sources3
Beta strandi222 – 226Combined sources5
Beta strandi231 – 233Combined sources3
Helixi237 – 241Combined sources5
Helixi242 – 246Combined sources5
Beta strandi249 – 251Combined sources3
Turni252 – 254Combined sources3
Beta strandi256 – 263Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JCKX-ray3.50B/D28-266[»]
1JWMX-ray2.70D28-266[»]
1JWSX-ray2.60D28-266[»]
1JWUX-ray2.30D28-266[»]
1KLGX-ray2.40D28-266[»]
1KLUX-ray1.93D28-266[»]
1SJEX-ray2.45D28-266[»]
1SJHX-ray2.25D28-266[»]
1T5XX-ray2.50D28-266[»]
2AQ1X-ray2.10B/D/F/H28-266[»]
2AQ2X-ray1.80B28-266[»]
2AQ3X-ray2.30B/D/F/H28-266[»]
2IPKX-ray2.30D28-266[»]
3BVGX-ray2.00A28-266[»]
3BVMX-ray2.00A28-266[»]
3BVZX-ray2.30A28-266[»]
3BYTX-ray2.30B/D/F/H28-266[»]
3BYYX-ray2.20B28-266[»]
3BZDX-ray2.30B28-266[»]
ProteinModelPortaliP0A0L5.
SMRiP0A0L5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0L5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A0L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKRLFISRV ILIFALILVI STPNVLAESQ PDPMPDDLHK SSEFTGTMGN
60 70 80 90 100
MKYLYDDHYV SATKVKSVDK FLAHDLIYNI SDKKLKNYDK VKTELLNEDL
110 120 130 140 150
AKKYKDEVVD VYGSNYYVNC YFSSKDNVGK VTGGKTCMYG GITKHEGNHF
160 170 180 190 200
DNGNLQNVLV RVYENKRNTI SFEVQTDKKS VTAQELDIKA RNFLINKKNL
210 220 230 240 250
YEFNSSPYET GYIKFIENNG NTFWYDMMPA PGDKFDQSKY LMMYNDNKTV
260
DSKSVKIEVH LTTKNG
Length:266
Mass (Da):30,671
Last modified:March 1, 2005 - v1
Checksum:i5ED8A32D11FFCA59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51661 Genomic DNA. Translation: CAA35972.1.
PIRiS11885.
RefSeqiWP_000278088.1. NZ_LSBF01000004.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51661 Genomic DNA. Translation: CAA35972.1.
PIRiS11885.
RefSeqiWP_000278088.1. NZ_LSBF01000004.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JCKX-ray3.50B/D28-266[»]
1JWMX-ray2.70D28-266[»]
1JWSX-ray2.60D28-266[»]
1JWUX-ray2.30D28-266[»]
1KLGX-ray2.40D28-266[»]
1KLUX-ray1.93D28-266[»]
1SJEX-ray2.45D28-266[»]
1SJHX-ray2.25D28-266[»]
1T5XX-ray2.50D28-266[»]
2AQ1X-ray2.10B/D/F/H28-266[»]
2AQ2X-ray1.80B28-266[»]
2AQ3X-ray2.30B/D/F/H28-266[»]
2IPKX-ray2.30D28-266[»]
3BVGX-ray2.00A28-266[»]
3BVMX-ray2.00A28-266[»]
3BVZX-ray2.30A28-266[»]
3BYTX-ray2.30B/D/F/H28-266[»]
3BYYX-ray2.20B28-266[»]
3BZDX-ray2.30B28-266[»]
ProteinModelPortaliP0A0L5.
SMRiP0A0L5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2009.

Protein family/group databases

Allergomei2141. Sta a SEC.

Proteomic databases

PaxDbiP0A0L5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0L5.
PROiP0A0L5.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENTC3_STAAU
AccessioniPrimary (citable) accession number: P0A0L5
Secondary accession number(s): P23313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.