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P0A0L5

- ENTC3_STAAU

UniProt

P0A0L5 - ENTC3_STAAU

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Protein

Enterotoxin type C-3

Gene

entC3

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type C-3
Alternative name(s):
SEC3
Gene namesi
Name:entC3
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2141. Sta a SEC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Add
BLAST
Chaini28 – 266239Enterotoxin type C-3PRO_0000035611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 137

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
266
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 373Combined sources
Helixi41 – 433Combined sources
Helixi49 – 524Combined sources
Turni53 – 553Combined sources
Beta strandi60 – 656Combined sources
Beta strandi69 – 724Combined sources
Beta strandi75 – 784Combined sources
Beta strandi83 – 9412Combined sources
Helixi98 – 1047Combined sources
Beta strandi109 – 1135Combined sources
Beta strandi122 – 1243Combined sources
Beta strandi134 – 1396Combined sources
Beta strandi142 – 1443Combined sources
Turni146 – 1483Combined sources
Turni151 – 1533Combined sources
Beta strandi156 – 1649Combined sources
Beta strandi167 – 18216Combined sources
Helixi183 – 19816Combined sources
Beta strandi200 – 2023Combined sources
Beta strandi207 – 21610Combined sources
Turni218 – 2203Combined sources
Beta strandi222 – 2265Combined sources
Beta strandi231 – 2333Combined sources
Helixi237 – 2415Combined sources
Helixi242 – 2465Combined sources
Beta strandi249 – 2513Combined sources
Turni252 – 2543Combined sources
Beta strandi256 – 2638Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JCKX-ray3.50B/D28-266[»]
1JWMX-ray2.70D28-266[»]
1JWSX-ray2.60D28-266[»]
1JWUX-ray2.30D28-266[»]
1KLGX-ray2.40D28-266[»]
1KLUX-ray1.93D28-266[»]
1SJEX-ray2.45D28-266[»]
1SJHX-ray2.25D28-266[»]
1T5XX-ray2.50D28-266[»]
2AQ1X-ray2.10B/D/F/H28-266[»]
2AQ2X-ray1.80B28-266[»]
2AQ3X-ray2.30B/D/F/H28-266[»]
2IPKX-ray2.30D28-266[»]
3BVGX-ray2.00A28-266[»]
3BVMX-ray2.00A28-266[»]
3BVZX-ray2.30A28-266[»]
3BYTX-ray2.30B/D/F/H28-266[»]
3BYYX-ray2.20B28-266[»]
3BZDX-ray2.30B28-266[»]
ProteinModelPortaliP0A0L5.
SMRiP0A0L5. Positions 28-266.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0L5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A0L5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYKRLFISRV ILIFALILVI STPNVLAESQ PDPMPDDLHK SSEFTGTMGN
60 70 80 90 100
MKYLYDDHYV SATKVKSVDK FLAHDLIYNI SDKKLKNYDK VKTELLNEDL
110 120 130 140 150
AKKYKDEVVD VYGSNYYVNC YFSSKDNVGK VTGGKTCMYG GITKHEGNHF
160 170 180 190 200
DNGNLQNVLV RVYENKRNTI SFEVQTDKKS VTAQELDIKA RNFLINKKNL
210 220 230 240 250
YEFNSSPYET GYIKFIENNG NTFWYDMMPA PGDKFDQSKY LMMYNDNKTV
260
DSKSVKIEVH LTTKNG
Length:266
Mass (Da):30,671
Last modified:March 1, 2005 - v1
Checksum:i5ED8A32D11FFCA59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51661 Genomic DNA. Translation: CAA35972.1.
PIRiS11885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51661 Genomic DNA. Translation: CAA35972.1 .
PIRi S11885.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JCK X-ray 3.50 B/D 28-266 [» ]
1JWM X-ray 2.70 D 28-266 [» ]
1JWS X-ray 2.60 D 28-266 [» ]
1JWU X-ray 2.30 D 28-266 [» ]
1KLG X-ray 2.40 D 28-266 [» ]
1KLU X-ray 1.93 D 28-266 [» ]
1SJE X-ray 2.45 D 28-266 [» ]
1SJH X-ray 2.25 D 28-266 [» ]
1T5X X-ray 2.50 D 28-266 [» ]
2AQ1 X-ray 2.10 B/D/F/H 28-266 [» ]
2AQ2 X-ray 1.80 B 28-266 [» ]
2AQ3 X-ray 2.30 B/D/F/H 28-266 [» ]
2IPK X-ray 2.30 D 28-266 [» ]
3BVG X-ray 2.00 A 28-266 [» ]
3BVM X-ray 2.00 A 28-266 [» ]
3BVZ X-ray 2.30 A 28-266 [» ]
3BYT X-ray 2.30 B/D/F/H 28-266 [» ]
3BYY X-ray 2.20 B 28-266 [» ]
3BZD X-ray 2.30 B 28-266 [» ]
ProteinModelPortali P0A0L5.
SMRi P0A0L5. Positions 28-266.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 2141. Sta a SEC.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P0A0L5.
PROi P0A0L5.

Family and domain databases

Gene3Di 3.10.20.120. 1 hit.
InterProi IPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view ]
Pfami PF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view ]
PRINTSi PR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMi SSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEi PS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the staphylococcal enterotoxin C3 gene: sequence comparison of all three type C staphylococcal enterotoxins."
    Hovde C.J., Hackett S.P., Bohach G.A.
    Mol. Gen. Genet. 220:329-333(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Crystal structure of a T-cell receptor beta-chain complexed with a superantigen."
    Fields B.A., Malchiodi E.L., Li H., Ysern X., Stauffacher C.V., Schlievert P.M., Karjalainen K., Mariuzza R.A.
    Nature 384:188-192(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF COMPLEX WITH TCR.

Entry informationi

Entry nameiENTC3_STAAU
AccessioniPrimary (citable) accession number: P0A0L5
Secondary accession number(s): P23313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3