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P0A0L5

- ENTC3_STAAU

UniProt

P0A0L5 - ENTC3_STAAU

Protein

Enterotoxin type C-3

Gene

entC3

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Enterotoxin, Superantigen, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enterotoxin type C-3
    Alternative name(s):
    SEC3
    Gene namesi
    Name:entC3
    OrganismiStaphylococcus aureus
    Taxonomic identifieri1280 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Protein family/group databases

    Allergomei2141. Sta a SEC.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Add
    BLAST
    Chaini28 – 266239Enterotoxin type C-3PRO_0000035611Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi120 ↔ 137

    Keywords - PTMi

    Disulfide bond

    Structurei

    Secondary structure

    1
    266
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi35 – 373
    Helixi41 – 433
    Helixi49 – 524
    Turni53 – 553
    Beta strandi60 – 656
    Beta strandi69 – 724
    Beta strandi75 – 784
    Beta strandi83 – 9412
    Helixi98 – 1047
    Beta strandi109 – 1135
    Beta strandi122 – 1243
    Beta strandi134 – 1396
    Beta strandi142 – 1443
    Turni146 – 1483
    Turni151 – 1533
    Beta strandi156 – 1649
    Beta strandi167 – 18216
    Helixi183 – 19816
    Beta strandi200 – 2023
    Beta strandi207 – 21610
    Turni218 – 2203
    Beta strandi222 – 2265
    Beta strandi231 – 2333
    Helixi237 – 2415
    Helixi242 – 2465
    Beta strandi249 – 2513
    Turni252 – 2543
    Beta strandi256 – 2638

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JCKX-ray3.50B/D28-266[»]
    1JWMX-ray2.70D28-266[»]
    1JWSX-ray2.60D28-266[»]
    1JWUX-ray2.30D28-266[»]
    1KLGX-ray2.40D28-266[»]
    1KLUX-ray1.93D28-266[»]
    1SJEX-ray2.45D28-266[»]
    1SJHX-ray2.25D28-266[»]
    1T5XX-ray2.50D28-266[»]
    2AQ1X-ray2.10B/D/F/H28-266[»]
    2AQ2X-ray1.80B28-266[»]
    2AQ3X-ray2.30B/D/F/H28-266[»]
    2IPKX-ray2.30D28-266[»]
    3BVGX-ray2.00A28-266[»]
    3BVMX-ray2.00A28-266[»]
    3BVZX-ray2.30A28-266[»]
    3BYTX-ray2.30B/D/F/H28-266[»]
    3BYYX-ray2.20B28-266[»]
    3BZDX-ray2.30B28-266[»]
    ProteinModelPortaliP0A0L5.
    SMRiP0A0L5. Positions 28-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0A0L5.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.10.20.120. 1 hit.
    InterProiIPR008992. Enterotoxin.
    IPR006126. Staph/Strept_toxin_CS.
    IPR006173. Staph_tox_OB.
    IPR016091. SuperAg_toxin_C.
    IPR013307. Superantigen_bac.
    IPR006123. Toxin_b-grasp_Staph/Strep.
    IPR006177. Toxin_bac.
    [Graphical view]
    PfamiPF02876. Stap_Strp_tox_C. 1 hit.
    PF01123. Stap_Strp_toxin. 1 hit.
    [Graphical view]
    PRINTSiPR00279. BACTRLTOXIN.
    PR01898. SAGSUPRFAMLY.
    SUPFAMiSSF50203. SSF50203. 1 hit.
    SSF54334. SSF54334. 1 hit.
    PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
    PS00278. STAPH_STREP_TOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0A0L5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYKRLFISRV ILIFALILVI STPNVLAESQ PDPMPDDLHK SSEFTGTMGN    50
    MKYLYDDHYV SATKVKSVDK FLAHDLIYNI SDKKLKNYDK VKTELLNEDL 100
    AKKYKDEVVD VYGSNYYVNC YFSSKDNVGK VTGGKTCMYG GITKHEGNHF 150
    DNGNLQNVLV RVYENKRNTI SFEVQTDKKS VTAQELDIKA RNFLINKKNL 200
    YEFNSSPYET GYIKFIENNG NTFWYDMMPA PGDKFDQSKY LMMYNDNKTV 250
    DSKSVKIEVH LTTKNG 266
    Length:266
    Mass (Da):30,671
    Last modified:March 1, 2005 - v1
    Checksum:i5ED8A32D11FFCA59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51661 Genomic DNA. Translation: CAA35972.1.
    PIRiS11885.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51661 Genomic DNA. Translation: CAA35972.1 .
    PIRi S11885.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JCK X-ray 3.50 B/D 28-266 [» ]
    1JWM X-ray 2.70 D 28-266 [» ]
    1JWS X-ray 2.60 D 28-266 [» ]
    1JWU X-ray 2.30 D 28-266 [» ]
    1KLG X-ray 2.40 D 28-266 [» ]
    1KLU X-ray 1.93 D 28-266 [» ]
    1SJE X-ray 2.45 D 28-266 [» ]
    1SJH X-ray 2.25 D 28-266 [» ]
    1T5X X-ray 2.50 D 28-266 [» ]
    2AQ1 X-ray 2.10 B/D/F/H 28-266 [» ]
    2AQ2 X-ray 1.80 B 28-266 [» ]
    2AQ3 X-ray 2.30 B/D/F/H 28-266 [» ]
    2IPK X-ray 2.30 D 28-266 [» ]
    3BVG X-ray 2.00 A 28-266 [» ]
    3BVM X-ray 2.00 A 28-266 [» ]
    3BVZ X-ray 2.30 A 28-266 [» ]
    3BYT X-ray 2.30 B/D/F/H 28-266 [» ]
    3BYY X-ray 2.20 B 28-266 [» ]
    3BZD X-ray 2.30 B 28-266 [» ]
    ProteinModelPortali P0A0L5.
    SMRi P0A0L5. Positions 28-266.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 2141. Sta a SEC.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P0A0L5.
    PROi P0A0L5.

    Family and domain databases

    Gene3Di 3.10.20.120. 1 hit.
    InterProi IPR008992. Enterotoxin.
    IPR006126. Staph/Strept_toxin_CS.
    IPR006173. Staph_tox_OB.
    IPR016091. SuperAg_toxin_C.
    IPR013307. Superantigen_bac.
    IPR006123. Toxin_b-grasp_Staph/Strep.
    IPR006177. Toxin_bac.
    [Graphical view ]
    Pfami PF02876. Stap_Strp_tox_C. 1 hit.
    PF01123. Stap_Strp_toxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00279. BACTRLTOXIN.
    PR01898. SAGSUPRFAMLY.
    SUPFAMi SSF50203. SSF50203. 1 hit.
    SSF54334. SSF54334. 1 hit.
    PROSITEi PS00277. STAPH_STREP_TOXIN_1. 1 hit.
    PS00278. STAPH_STREP_TOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the staphylococcal enterotoxin C3 gene: sequence comparison of all three type C staphylococcal enterotoxins."
      Hovde C.J., Hackett S.P., Bohach G.A.
      Mol. Gen. Genet. 220:329-333(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Crystal structure of a T-cell receptor beta-chain complexed with a superantigen."
      Fields B.A., Malchiodi E.L., Li H., Ysern X., Stauffacher C.V., Schlievert P.M., Karjalainen K., Mariuzza R.A.
      Nature 384:188-192(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF COMPLEX WITH TCR.

    Entry informationi

    Entry nameiENTC3_STAAU
    AccessioniPrimary (citable) accession number: P0A0L5
    Secondary accession number(s): P23313
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3