P0A0L4 (ENTC3_STAAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Enterotoxin type C-3

Alternative name(s):
SEC3

Gene names

Name:	entC3
Ordered Locus Names:	SA1817

Organism

Staphylococcus aureus (strain N315) [Complete proteome] [HAMAP]

Taxonomic identifier

158879 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
Subcellular location	Secreted.
Sequence similarities	Belongs to the staphylococcal/streptococcal toxin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Enterotoxin Superantigen Toxin
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	By similarity
	Chain	28 – 266	239	Enterotoxin type C-3		PRO_0000035610
Amino acid modifications
	Disulfide bond	120 ↔ 137		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A0L4 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 5ED8A32D11FFCA59	FASTA	266	30,671
	10 20 30 40 50 60 MYKRLFISRV ILIFALILVI STPNVLAESQ PDPMPDDLHK SSEFTGTMGN MKYLYDDHYV 70 80 90 100 110 120 SATKVKSVDK FLAHDLIYNI SDKKLKNYDK VKTELLNEDL AKKYKDEVVD VYGSNYYVNC 130 140 150 160 170 180 YFSSKDNVGK VTGGKTCMYG GITKHEGNHF DNGNLQNVLV RVYENKRNTI SFEVQTDKKS 190 200 210 220 230 240 VTAQELDIKA RNFLINKKNL YEFNSSPYET GYIKFIENNG NTFWYDMMPA PGDKFDQSKY 250 260 LMMYNDNKTV DSKSVKIEVH LTTKNG

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: N315.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000018 Genomic DNA. Translation: BAB43097.1.
RefSeq	NP_375118.1. NC_002745.2.
3D structure databases
ProteinModelPortal	P0A0L4.
SMR	P0A0L4. Positions 28-266.
ModBase	Search...
Protein-protein interaction databases
STRING	158879.SA1817.
Protein family/group databases
Allergome	2141. Sta a SEC.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB43097; BAB43097; BAB43097.
GeneID	1124709.
KEGG	sau:SA1817.
PATRIC	19576068. VBIStaAur116463_1966.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG12203.
HOGENOM	HOG000232691.
KO	K11040.
OMA	GLMENMK.
ProtClustDB	CLSK885720.
Enzyme and pathway databases
BioCyc	SAUR158879:GJCB-1941-MONOMER.
Family and domain databases
Gene3D	3.10.20.120. 1 hit.
InterPro	IPR008992. Enterotoxin_bac. IPR006126. Staph/Strept_toxin_CS. IPR006173. Staph_tox_OB. IPR016091. SuperAg_toxin_C. IPR013307. Superantigen_bac. IPR006123. Toxin_b-grasp_Staph/Strep. IPR006177. Toxin_bac. [Graphical view]
Pfam	PF02876. Stap_Strp_tox_C. 1 hit. PF01123. Stap_Strp_toxin. 1 hit. [Graphical view]
PRINTS	PR00279. BACTRLTOXIN. PR01898. SAGSUPRFAMLY.
SUPFAM	SSF50203. Bact_endotox. 1 hit. SSF54334. Stap/Strep_toxin. 1 hit.
PROSITE	PS00277. STAPH_STREP_TOXIN_1. 1 hit. PS00278. STAPH_STREP_TOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ENTC3_STAAN

Accession

Primary (citable) accession number: P0A0L4
Secondary accession number(s): P23313

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program