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P0A0L3

- ENTC3_STAAM

UniProt

P0A0L3 - ENTC3_STAAM

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Protein

Enterotoxin type C-3

Gene
entC3, SAV2009
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2065-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type C-3
Alternative name(s):
SEC3
Gene namesi
Name:entC3
Ordered Locus Names:SAV2009
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2141. Sta a SEC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 By similarityAdd
BLAST
Chaini28 – 266239Enterotoxin type C-3PRO_0000035609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 137 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2009.

Structurei

Secondary structure

1
266
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 373
Helixi41 – 433
Helixi49 – 557
Beta strandi60 – 656
Beta strandi75 – 795
Turni83 – 853
Beta strandi89 – 946
Helixi98 – 1058
Beta strandi109 – 1135
Beta strandi135 – 1395
Beta strandi142 – 1443
Turni151 – 1533
Beta strandi156 – 1649
Beta strandi167 – 18216
Helixi183 – 19816
Beta strandi203 – 2053
Beta strandi209 – 2168
Beta strandi222 – 2265
Beta strandi231 – 2333
Helixi237 – 2415
Helixi242 – 2465
Beta strandi249 – 2513
Turni252 – 2543
Beta strandi256 – 2627

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PYWX-ray2.10D28-266[»]
ProteinModelPortaliP0A0L3.
SMRiP0A0L3. Positions 28-266.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12203.
HOGENOMiHOG000232691.
KOiK11040.
OMAiGLMENMK.
OrthoDBiEOG6H4K5S.
PhylomeDBiP0A0L3.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A0L3-1 [UniParc]FASTAAdd to Basket

« Hide

MYKRLFISRV ILIFALILVI STPNVLAESQ PDPMPDDLHK SSEFTGTMGN    50
MKYLYDDHYV SATKVKSVDK FLAHDLIYNI SDKKLKNYDK VKTELLNEDL 100
AKKYKDEVVD VYGSNYYVNC YFSSKDNVGK VTGGKTCMYG GITKHEGNHF 150
DNGNLQNVLV RVYENKRNTI SFEVQTDKKS VTAQELDIKA RNFLINKKNL 200
YEFNSSPYET GYIKFIENNG NTFWYDMMPA PGDKFDQSKY LMMYNDNKTV 250
DSKSVKIEVH LTTKNG 266
Length:266
Mass (Da):30,671
Last modified:March 1, 2005 - v1
Checksum:i5ED8A32D11FFCA59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB58171.1.
RefSeqiNP_372533.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58171; BAB58171; SAV2009.
GeneIDi1122021.
KEGGisav:SAV2009.
PATRICi19564882. VBIStaAur52173_2081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB58171.1 .
RefSeqi NP_372533.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PYW X-ray 2.10 D 28-266 [» ]
ProteinModelPortali P0A0L3.
SMRi P0A0L3. Positions 28-266.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158878.SAV2009.

Protein family/group databases

Allergomei 2141. Sta a SEC.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB58171 ; BAB58171 ; SAV2009 .
GeneIDi 1122021.
KEGGi sav:SAV2009.
PATRICi 19564882. VBIStaAur52173_2081.

Phylogenomic databases

eggNOGi NOG12203.
HOGENOMi HOG000232691.
KOi K11040.
OMAi GLMENMK.
OrthoDBi EOG6H4K5S.
PhylomeDBi P0A0L3.

Enzyme and pathway databases

BioCyci SAUR158878:GJJ5-2065-MONOMER.

Miscellaneous databases

PROi P0A0L3.

Family and domain databases

Gene3Di 3.10.20.120. 1 hit.
InterProi IPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view ]
Pfami PF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view ]
PRINTSi PR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMi SSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEi PS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiENTC3_STAAM
AccessioniPrimary (citable) accession number: P0A0L3
Secondary accession number(s): P23313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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