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P0A0L2

- ETXA_STAAU

UniProt

P0A0L2 - ETXA_STAAU

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Protein
Enterotoxin type A
Gene
entA
Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Cofactori

Binds 1 zinc ion per subunit. The zinc ion is necessary for the toxin interaction with MHC class II.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi211 – 2111Zinc
Metal bindingi249 – 2491Zinc
Metal bindingi251 – 2511Zinc

GO - Molecular functioni

  1. MHC class II protein binding Source: BHF-UCL
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type A
Alternative name(s):
SEA
Gene namesi
Name:entA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2139. Sta a SEA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 Publication
Add
BLAST
Chaini25 – 257233Enterotoxin type A
PRO_0000035604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 130

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

DIPiDIP-58974N.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi28 – 314
Helixi33 – 353
Helixi39 – 413
Helixi46 – 5510
Beta strandi59 – 657
Beta strandi72 – 787
Beta strandi84 – 874
Beta strandi89 – 946
Helixi98 – 1047
Beta strandi109 – 1146
Helixi117 – 1193
Beta strandi122 – 1243
Helixi125 – 1273
Beta strandi128 – 1336
Beta strandi135 – 1373
Turni139 – 1413
Beta strandi142 – 1487
Beta strandi151 – 1555
Beta strandi158 – 1603
Beta strandi166 – 17510
Helixi176 – 19116
Beta strandi193 – 1953
Helixi197 – 1993
Beta strandi205 – 2117
Beta strandi213 – 2153
Beta strandi218 – 2214
Beta strandi227 – 2293
Turni230 – 2323
Helixi233 – 2375
Beta strandi242 – 2443
Beta strandi249 – 2557

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DYQX-ray1.50A25-257[»]
1ESFX-ray1.90A/B25-257[»]
1I4GX-ray2.10A/B25-257[»]
1I4HX-ray2.90A/B25-257[»]
1LO5X-ray3.20D25-257[»]
1SEAmodel-A25-257[»]
1SXTX-ray2.70A/B25-257[»]
ProteinModelPortaliP0A0L2.
SMRiP0A0L2. Positions 34-257.

Miscellaneous databases

EvolutionaryTraceiP0A0L2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A0L2-1 [UniParc]FASTAAdd to Basket

« Hide

MKKTAFTLLL FIALTLTTSP LVNGSEKSEE INEKDLRKKS ELQGTALGNL    50
KQIYYYNEKA KTENKESHDQ FLQHTILFKG FFTDHSWYND LLVDFDSKDI 100
VDKYKGKKVD LYGAYYGYQC AGGTPNKTAC MYGGVTLHDN NRLTEEKKVP 150
INLWLDGKQN TVPLETVKTN KKNVTVQELD LQARRYLQEK YNLYNSDVFD 200
GKVQRGLIVF HTSTEPSVNY DLFGAQGQYS NTLLRIYRDN KTINSENMHI 250
DIYLYTS 257
Length:257
Mass (Da):29,669
Last modified:February 15, 2005 - v1
Checksum:iADEBF5BCA1F14677
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 2421T → S AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18970 Genomic DNA. Translation: AAA26681.1.
PIRiA28664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18970 Genomic DNA. Translation: AAA26681.1 .
PIRi A28664.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DYQ X-ray 1.50 A 25-257 [» ]
1ESF X-ray 1.90 A/B 25-257 [» ]
1I4G X-ray 2.10 A/B 25-257 [» ]
1I4H X-ray 2.90 A/B 25-257 [» ]
1LO5 X-ray 3.20 D 25-257 [» ]
1SEA model - A 25-257 [» ]
1SXT X-ray 2.70 A/B 25-257 [» ]
ProteinModelPortali P0A0L2.
SMRi P0A0L2. Positions 34-257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-58974N.

Protein family/group databases

Allergomei 2139. Sta a SEA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P0A0L2.
PROi P0A0L2.

Family and domain databases

Gene3Di 3.10.20.120. 1 hit.
InterProi IPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view ]
Pfami PF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view ]
PRINTSi PR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMi SSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEi PS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the type A staphylococcal enterotoxin gene."
    Betley M.J., Mekalanos J.J.
    J. Bacteriol. 170:34-41(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FRI337.
  2. "Complete amino acid sequence of staphylococcal enterotoxin A."
    Huang I.-Y., Hughes J.L., Bergdoll M.S., Schantz E.J.
    J. Biol. Chem. 262:7006-7013(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-257.
  3. "Crystal structure of the superantigen staphylococcal enterotoxin type A."
    Schad E.M., Zaitseva I., Zaitsev V.N., Dohlsten M., Kalland T., Schlievert P.M., Ohlendorf D.H., Svensson L.A.
    EMBO J. 14:3292-3301(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
  4. "The Co-crystal structure of staphylococcal enterotoxin type A with Zn2+ at 2.7-A resolution. Implications for major histocompatibility complex class II binding."
    Sundstroem M., Hallen D., Svensson A., Schad E., Dohlsten M., Abrahmsen L.
    J. Biol. Chem. 271:32212-32216(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
  5. "Residues defining V beta specificity in staphylococcal enterotoxins."
    Swaminathan S., Furey W.F. Jr., Pletcher J., Sax M.
    Nat. Struct. Biol. 2:680-686(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.
  6. "A structural and functional comparison of staphylococcal enterotoxins A and C2 reveals remarkable similarity and dissimilarity."
    Schad E.M., Papageorgiou A.C., Svensson L.A., Acharya K.R.
    J. Mol. Biol. 269:270-280(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPARISON OF STRUCTURE OF SEA AND SEC2.

Entry informationi

Entry nameiETXA_STAAU
AccessioniPrimary (citable) accession number: P0A0L2
Secondary accession number(s): P13163
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This toxin seems to be coded by a bacteriophage.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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