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Protein

Enterotoxin type A

Gene

entA

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit. The zinc ion is necessary for the toxin interaction with MHC class II.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi211Zinc1
Metal bindingi249Zinc1
Metal bindingi251Zinc1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • MHC class II protein binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type A
Alternative name(s):
SEA
Gene namesi
Name:entA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2139. Sta a SEA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000003560425 – 257Enterotoxin type AAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi120 ↔ 130

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0A0L2.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

  • MHC class II protein binding Source: BHF-UCL

Protein-protein interaction databases

DIPiDIP-58974N.
STRINGi158878.SAV1948.

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 31Combined sources4
Helixi33 – 35Combined sources3
Helixi39 – 41Combined sources3
Turni43 – 45Combined sources3
Helixi46 – 55Combined sources10
Beta strandi59 – 65Combined sources7
Beta strandi72 – 78Combined sources7
Beta strandi84 – 87Combined sources4
Beta strandi89 – 94Combined sources6
Helixi98 – 104Combined sources7
Beta strandi109 – 114Combined sources6
Helixi117 – 119Combined sources3
Beta strandi122 – 124Combined sources3
Helixi125 – 127Combined sources3
Beta strandi128 – 133Combined sources6
Beta strandi135 – 137Combined sources3
Turni139 – 141Combined sources3
Beta strandi142 – 148Combined sources7
Beta strandi151 – 155Combined sources5
Beta strandi158 – 160Combined sources3
Beta strandi166 – 175Combined sources10
Helixi176 – 191Combined sources16
Beta strandi193 – 195Combined sources3
Helixi197 – 199Combined sources3
Beta strandi205 – 211Combined sources7
Beta strandi213 – 215Combined sources3
Beta strandi218 – 221Combined sources4
Beta strandi227 – 229Combined sources3
Turni230 – 232Combined sources3
Helixi233 – 237Combined sources5
Beta strandi242 – 244Combined sources3
Beta strandi249 – 255Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DYQX-ray1.50A25-257[»]
1ESFX-ray1.90A/B25-257[»]
1I4GX-ray2.10A/B25-257[»]
1I4HX-ray2.90A/B25-257[»]
1LO5X-ray3.20D25-257[»]
1SEAmodel-A25-257[»]
1SXTX-ray2.70A/B25-257[»]
5FK9X-ray3.10C25-257[»]
ProteinModelPortaliP0A0L2.
SMRiP0A0L2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0L2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A0L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTAFTLLL FIALTLTTSP LVNGSEKSEE INEKDLRKKS ELQGTALGNL
60 70 80 90 100
KQIYYYNEKA KTENKESHDQ FLQHTILFKG FFTDHSWYND LLVDFDSKDI
110 120 130 140 150
VDKYKGKKVD LYGAYYGYQC AGGTPNKTAC MYGGVTLHDN NRLTEEKKVP
160 170 180 190 200
INLWLDGKQN TVPLETVKTN KKNVTVQELD LQARRYLQEK YNLYNSDVFD
210 220 230 240 250
GKVQRGLIVF HTSTEPSVNY DLFGAQGQYS NTLLRIYRDN KTINSENMHI

DIYLYTS
Length:257
Mass (Da):29,669
Last modified:February 15, 2005 - v1
Checksum:iADEBF5BCA1F14677
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242T → S AA sequence (PubMed:3584106).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18970 Genomic DNA. Translation: AAA26681.1.
PIRiA28664.
RefSeqiWP_000750412.1. NZ_LWBY01000019.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18970 Genomic DNA. Translation: AAA26681.1.
PIRiA28664.
RefSeqiWP_000750412.1. NZ_LWBY01000019.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DYQX-ray1.50A25-257[»]
1ESFX-ray1.90A/B25-257[»]
1I4GX-ray2.10A/B25-257[»]
1I4HX-ray2.90A/B25-257[»]
1LO5X-ray3.20D25-257[»]
1SEAmodel-A25-257[»]
1SXTX-ray2.70A/B25-257[»]
5FK9X-ray3.10C25-257[»]
ProteinModelPortaliP0A0L2.
SMRiP0A0L2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-58974N.
STRINGi158878.SAV1948.

Protein family/group databases

Allergomei2139. Sta a SEA.

Proteomic databases

PaxDbiP0A0L2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0L2.
PROiP0A0L2.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETXA_STAAU
AccessioniPrimary (citable) accession number: P0A0L2
Secondary accession number(s): P13163
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This toxin seems to be coded by a bacteriophage.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.