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Protein

Thioredoxin

Gene

trxA

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin
Short name:
Trx
Gene namesi
Name:trxA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001201311 – 104ThioredoxinAdd BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 32Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

Expressed in both aerobic and anaerobic conditions.1 Publication

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni8 – 10Combined sources3
Helixi11 – 14Combined sources4
Beta strandi17 – 25Combined sources9
Helixi30 – 45Combined sources16
Turni46 – 49Combined sources4
Beta strandi51 – 56Combined sources6
Turni57 – 59Combined sources3
Helixi61 – 66Combined sources6
Beta strandi71 – 79Combined sources9
Beta strandi82 – 89Combined sources8
Helixi93 – 101Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O7KX-ray2.20A1-104[»]
2O85X-ray2.20A1-104[»]
2O87X-ray2.40A2-104[»]
2O89X-ray2.55A1-104[»]
3DIEX-ray1.85A/B1-104[»]
ProteinModelPortaliP0A0K6
SMRiP0A0K6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0K6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 104ThioredoxinPROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105K63 Bacteria
COG0526 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR10438 PTHR10438, 1 hit
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
PIRSFiPIRSF000077 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01068 thioredoxin, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A0K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVKVTDAD FDSKVESGVQ LVDFWATWCG PCKMIAPVLE ELAADYEGKA
60 70 80 90 100
DILKLDVDEN PSTAAKYEVM SIPTLIVFKD GQPVDKVVGF QPKENLAEVL

DKHL
Length:104
Mass (Da):11,440
Last modified:March 1, 2005 - v1
Checksum:iFE61559DB27B3920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223480 Genomic DNA Translation: CAA11404.1
RefSeqiWP_001018928.1, NZ_PQWV01000003.1

Similar proteinsi

Entry informationi

Entry nameiTHIO_STAAU
AccessioniPrimary (citable) accession number: P0A0K6
Secondary accession number(s): Q9ZEH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure
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Main funding by: National Institutes of Health