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Protein

Thioredoxin

Gene

trxA

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin
Short name:
Trx
Gene namesi
Name:trxA
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001201311 – 104ThioredoxinAdd BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 32Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

Expressed in both aerobic and anaerobic conditions.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL1155.

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni8 – 10Combined sources3
Helixi11 – 14Combined sources4
Beta strandi17 – 25Combined sources9
Helixi30 – 45Combined sources16
Turni46 – 49Combined sources4
Beta strandi51 – 56Combined sources6
Turni57 – 59Combined sources3
Helixi61 – 66Combined sources6
Beta strandi71 – 79Combined sources9
Beta strandi82 – 89Combined sources8
Helixi93 – 101Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O7KX-ray2.20A1-104[»]
2O85X-ray2.20A1-104[»]
2O87X-ray2.40A2-104[»]
2O89X-ray2.55A1-104[»]
3DIEX-ray1.85A/B1-104[»]
ProteinModelPortaliP0A0K6.
SMRiP0A0K6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A0K6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 104ThioredoxinPROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105K63. Bacteria.
COG0526. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiView protein in Pfam
PF00085. Thioredoxin. 1 hit.
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiView protein in PROSITE
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A0K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVKVTDAD FDSKVESGVQ LVDFWATWCG PCKMIAPVLE ELAADYEGKA
60 70 80 90 100
DILKLDVDEN PSTAAKYEVM SIPTLIVFKD GQPVDKVVGF QPKENLAEVL

DKHL
Length:104
Mass (Da):11,440
Last modified:March 1, 2005 - v1
Checksum:iFE61559DB27B3920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223480 Genomic DNA. Translation: CAA11404.1.
RefSeqiWP_001018928.1. NZ_MUEG01000032.1.

Genome annotation databases

GeneIDi31213903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223480 Genomic DNA. Translation: CAA11404.1.
RefSeqiWP_001018928.1. NZ_MUEG01000032.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O7KX-ray2.20A1-104[»]
2O85X-ray2.20A1-104[»]
2O87X-ray2.40A2-104[»]
2O89X-ray2.55A1-104[»]
3DIEX-ray1.85A/B1-104[»]
ProteinModelPortaliP0A0K6.
SMRiP0A0K6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL1155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi31213903.

Phylogenomic databases

eggNOGiENOG4105K63. Bacteria.
COG0526. LUCA.

Miscellaneous databases

EvolutionaryTraceiP0A0K6.

Family and domain databases

InterProiView protein in InterPro
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiView protein in Pfam
PF00085. Thioredoxin. 1 hit.
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiView protein in PROSITE
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTHIO_STAAU
AccessioniPrimary (citable) accession number: P0A0K6
Secondary accession number(s): Q9ZEH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: May 10, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.